SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pla'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 5 ARG A 273
ALA A 276
ASP A 217
GLY A 218
 None
 1.22A 1e7cA-2plaA:
2.3		 1e7cA-2plaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A  20
ALA A  19
HIS A  69
 None
None
PO4  A 503 (-4.1A)
 0.69A 1q23C-2plaA:
undetectable		 1q23C-2plaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A  20
ALA A  19
HIS A  69
 None
None
PO4  A 503 (-4.1A)
 0.67A 1q23G-2plaA:
undetectable		 1q23G-2plaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 VAL A  20
ALA A  19
HIS A  69
 None
None
PO4  A 503 (-4.1A)
 0.69A 1q23L-2plaA:
undetectable		 1q23L-2plaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 PHE A 188
LEU A 183
LEU A 182
PRO A  72
 None
 0.97A 2jn3A-2plaA:
undetectable		 2jn3A-2plaA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KUH_A_HLTA150_1
(CALMODULIN)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 205
LEU A 263
MET A 237
GLU A 236
 None
 1.24A 2kuhA-2plaA:
undetectable		 2kuhA-2plaA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 ALA A 155
ASN A 156
ALA A 159
ALA A  19
SER A  18
 NAD  A 401 (-3.5A)
None
None
None
None
 1.09A 2r2vC-2plaA:
undetectable
2r2vF-2plaA:
undetectable
2r2vG-2plaA:
undetectable		 2r2vC-2plaA:
7.74
2r2vF-2plaA:
7.74
2r2vG-2plaA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 LEU A 182
VAL A  20
LEU A  90
VAL A  94
ILE A  10
 None
None
None
NAD  A 401 ( 4.8A)
None
 1.07A 2uxoB-2plaA:
0.9		 2uxoB-2plaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 ILE A 208
ALA A 326
PHE A 321
PHE A 324
VAL A 209
 None
 1.20A 2w3aA-2plaA:
undetectable		 2w3aA-2plaA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 5 SER A 135
LEU A 149
GLY A 169
GLU A 200
 None
 1.22A 3aiaA-2plaA:
undetectable
3aiaB-2plaA:
undetectable		 3aiaA-2plaA:
21.11
3aiaB-2plaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 116
SER A 147
LEU A 177
PHE A 179
VAL A 192
 None
 1.16A 3w68A-2plaA:
undetectable		 3w68A-2plaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 GLU A 307
GLN A 300
ILE A  95
PHE A  99
 None
None
None
NAD  A 401 (-3.3A)
 0.88A 4dx7B-2plaA:
2.5		 4dx7B-2plaA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 ILE A 138
ARG A 102
LEU A  81
ILE A  95
 None
NAD  A 401 (-3.7A)
None
None
 0.88A 4xtaB-2plaA:
undetectable		 4xtaB-2plaA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 276
GLY A 214
GLY A 218
LEU A 219
GLU A 236
 None
 0.94A 5c0oG-2plaA:
5.4		 5c0oG-2plaA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 GLU A 181
LEU A 178
LYS A  33
LEU A  31
 None
 1.18A 5yvnA-2plaA:
undetectable		 5yvnA-2plaA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRF_D_EVPD101_1
()		 2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens) 		4 / 5 GLY A 214
ASP A 217
ARG A 281
GLN A 338
 None
 1.30A 5zrfB-2plaA:
undetectable		 5zrfB-2plaA:
18.85