SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2plc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ILE A 143
SER A 176
ASN A 178
THR A 180
 None
 1.06A 1h7xA-2plcA:
undetectable		 1h7xA-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ILE A 289
ASN A 292
SER A  40
THR A 265
 None
 1.26A 1h7xA-2plcA:
undetectable		 1h7xA-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ILE A 143
SER A 176
ASN A 178
THR A 180
 None
 1.07A 1h7xB-2plcA:
6.0		 1h7xB-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ILE A 289
ASN A 292
SER A  40
THR A 265
 None
 1.24A 1h7xB-2plcA:
6.0		 1h7xB-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ILE A 143
SER A 176
ASN A 178
THR A 180
 None
 1.06A 1h7xC-2plcA:
5.2		 1h7xC-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ILE A 289
ASN A 292
SER A  40
THR A 265
 None
 1.25A 1h7xC-2plcA:
5.2		 1h7xC-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ILE A 143
SER A 176
ASN A 178
THR A 180
 None
 1.07A 1h7xD-2plcA:
5.7		 1h7xD-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ILE A 289
ASN A 292
SER A  40
THR A 265
 None
 1.26A 1h7xD-2plcA:
5.7		 1h7xD-2plcA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		5 / 11 PRO A  61
HIS A  93
GLY A  52
ASP A  53
ILE A  91
 None
 1.08A 1jzsA-2plcA:
undetectable		 1jzsA-2plcA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 ASP A 229
GLY A 273
ILE A  41
ILE A 162
 None
 0.93A 1n49D-2plcA:
undetectable		 1n49D-2plcA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 4 LEU A 102
ILE A 121
ARG A  79
TYR A 146
 None
 1.41A 1rk3A-2plcA:
undetectable		 1rk3A-2plcA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 5 LEU A 102
ILE A 121
ARG A  79
TYR A 146
 None
 1.37A 2zlcA-2plcA:
undetectable		 2zlcA-2plcA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		5 / 12 ASN A 230
GLY A 273
ASN A 235
ARG A 124
PHE A 195
 None
 1.13A 3a27A-2plcA:
undetectable		 3a27A-2plcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		3 / 3 ASN A 287
ASN A 255
GLU A 281
 None
 0.87A 3kpdC-2plcA:
undetectable		 3kpdC-2plcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 7 LEU A  36
LEU A  39
PRO A  42
ILE A  41
 None
 0.70A 3s56B-2plcA:
undetectable		 3s56B-2plcA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		4 / 6 LYS A 293
GLY A 271
SER A  40
LEU A  39
 None
 0.97A 5bphA-2plcA:
undetectable		 5bphA-2plcA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		3 / 3 ARG A 124
HIS A  45
ARG A  84
 None
 0.94A 5iaoC-2plcA:
undetectable		 5iaoC-2plcA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 2plc PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C
(Listeria
monocytogenes) 		3 / 3 ARG A 124
HIS A  45
ARG A  84
 None
 0.92A 5iaoF-2plcA:
undetectable		 5iaoF-2plcA:
19.78