SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2plj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 12 PHE A 154
LEU A 152
VAL A 150
VAL A 215
THR A 211
 None
 1.24A 1q23B-2pljA:
undetectable		 1q23B-2pljA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 6 ASP A 358
LEU A 359
VAL A 360
ILE A 361
 None
 0.84A 1s9qA-2pljA:
undetectable		 1s9qA-2pljA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 12 LEU A 191
LEU A 230
VAL A 265
LEU A 261
ARG A 213
 None
 1.16A 2bxfA-2pljA:
undetectable		 2bxfA-2pljA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 12 VAL A  59
LEU A  56
ILE A 254
ILE A 209
ALA A 208
 None
 1.09A 2gj5A-2pljA:
undetectable		 2gj5A-2pljA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 12 ILE A 323
THR A 321
LYS A  16
LEU A  18
VAL A  30
 None
 1.28A 2jn3A-2pljA:
undetectable		 2jn3A-2pljA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 6 ALA A 367
TYR A 368
ASP A 314
TYR A 240
 None
P3T  A 501 (-3.5A)
P3T  A 501 (-3.7A)
None
 1.06A 2pncB-2pljA:
undetectable		 2pncB-2pljA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 8 ILE A 232
LEU A  61
PHE A 236
PHE A 250
 None
 0.81A 2vctC-2pljA:
undetectable		 2vctC-2pljA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 12 GLY A 336
ALA A 284
ASP A 302
VAL A 333
LEU A 320
 None
 0.86A 2yqzA-2pljA:
undetectable		 2yqzA-2pljA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 12 GLY A 336
ALA A 284
ASP A 302
VAL A 333
LEU A 320
 None
 0.85A 2yqzB-2pljA:
undetectable		 2yqzB-2pljA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 8 SER A 197
ARG A 273
THR A 369
THR A 372
 P3T  A 501 (-2.5A)
P3T  A 501 (-4.8A)
None
None
 0.89A 3bpxA-2pljA:
undetectable
3bpxB-2pljA:
undetectable		 3bpxA-2pljA:
17.87
3bpxB-2pljA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_B_AG2B1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 9 LYS A  66
HIS A 194
GLY A 196
SER A 197
TYR A 368
 P3T  A 501 (-1.2A)
P3T  A 501 (-3.8A)
None
P3T  A 501 (-2.5A)
P3T  A 501 (-3.5A)
 0.49A 3n2oA-2pljA:
25.4
3n2oB-2pljA:
10.3		 3n2oA-2pljA:
22.63
3n2oB-2pljA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		5 / 10 LYS A  66
HIS A 194
GLY A 196
ARG A 273
TYR A 368
 P3T  A 501 (-1.2A)
P3T  A 501 (-3.8A)
None
P3T  A 501 (-4.8A)
P3T  A 501 (-3.5A)
 0.48A 3n2oC-2pljA:
25.5
3n2oD-2pljA:
25.5		 3n2oC-2pljA:
22.63
3n2oD-2pljA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		3 / 3 LYS A 166
ARG A 151
LYS A 138
 None
P3T  A 501 (-3.9A)
None
 1.43A 3okxA-2pljA:
undetectable		 3okxA-2pljA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 6 PHE A 128
ILE A 117
ARG A 118
VAL A  92
 None
 1.15A 4mk4B-2pljA:
undetectable		 4mk4B-2pljA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		3 / 3 SER A 370
GLU A  91
GLU A 270
 None
None
P3T  A 501 (-3.7A)
 0.76A 4ymgB-2pljA:
undetectable		 4ymgB-2pljA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 5 THR A 108
HIS A 107
ALA A  87
ASP A  85
 None
None
None
P3T  A 501 ( 4.6A)
 1.16A 5mfxA-2pljA:
undetectable		 5mfxA-2pljA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		4 / 5 ALA A 269
VAL A 267
PHE A 236
ILE A 209
 None
 0.91A 5of1A-2pljA:
undetectable		 5of1A-2pljA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		3 / 3 TYR A  49
ALA A  55
LEU A  56
 None
 0.66A 6ag0C-2pljA:
4.2		 6ag0C-2pljA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 2plj LYSINE/ORNITHINE
DECARBOXYLASE
(Vibrio
vulnificus) 		3 / 3 ALA A  55
PHE A 274
GLN A  48
 None
 0.84A 6eceA-2pljA:
2.6		 6eceA-2pljA:
20.05