SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pls'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2pls CBS DOMAIN PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 LEU A 409
TRP A 407
GLY A 369
 None
 0.81A 3l35A-2plsA:
undetectable
3l35H-2plsA:
undetectable		 3l35A-2plsA:
21.95
3l35H-2plsA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 2pls CBS DOMAIN PROTEIN
(Chlorobaculum
tepidum) 		3 / 3 LEU A 409
TRP A 407
GLY A 369
 None
 0.81A 3l35B-2plsA:
undetectable
3l35K-2plsA:
undetectable		 3l35B-2plsA:
21.95
3l35K-2plsA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pls CBS DOMAIN PROTEIN
(Chlorobaculum
tepidum) 		4 / 8 THR A 402
GLU A 405
VAL A 361
LEU A 364
 None
 0.87A 4r38B-2plsA:
undetectable		 4r38B-2plsA:
20.42