SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2plw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		7 / 12 ALA A   6
GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A 132
LYS A 153
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-4.9A)
SAM  A 203 ( 4.1A)
 0.75A 1eizA-2plwA:
24.7		 1eizA-2plwA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		7 / 12 ALA A   6
GLY A  30
PRO A  33
GLY A  34
TRP A  36
LEU A 132
LYS A 153
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-4.9A)
SAM  A 203 ( 4.1A)
 0.72A 1ej0A-2plwA:
24.8		 1ej0A-2plwA:
28.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 5 ASP A  95
VAL A  94
SER A  93
GLN A 142
 None
 1.30A 1n2xB-2plwA:
14.2		 1n2xB-2plwA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 PRO A  33
ASP A  55
ASP A 113
 SAM  A 203 (-3.5A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.6A)
 0.36A 1sqfA-2plwA:
12.4		 1sqfA-2plwA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 ILE A  29
GLY A  30
PRO A  33
GLY A  34
ALA A 115
 None
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
None
 0.72A 1vptA-2plwA:
10.6		 1vptA-2plwA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 GLY A  30
GLY A  34
TRP A  36
LEU A 132
LYS A 153
 SAM  A 203 (-3.4A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-4.9A)
SAM  A 203 ( 4.1A)
 0.66A 2nyuA-2plwA:
25.7		 2nyuA-2plwA:
33.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYU_B_SAMB201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 GLY A  30
GLY A  34
TRP A  36
LEU A 132
LYS A 153
 SAM  A 203 (-3.4A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-4.9A)
SAM  A 203 ( 4.1A)
 0.57A 2nyuB-2plwA:
25.9		 2nyuB-2plwA:
33.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		12 / 12 ALA A   6
GLY A  30
TYR A  32
PRO A  33
GLY A  34
TRP A  36
LYS A  56
LYS A  57
GLU A  71
ILE A  72
ALA A 114
LEU A 132
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
None
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
None
SAM  A 203 (-3.2A)
SAM  A 203 (-4.9A)
SAM  A 203 (-4.4A)
SAM  A 203 (-3.6A)
SAM  A 203 (-4.9A)
 0.00A 2plwA-2plwA:
38.5		 2plwA-2plwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		6 / 12 ALA A   6
TYR A  32
PRO A  33
LYS A  56
LYS A  57
ALA A 115
 SAM  A 203 (-3.5A)
None
SAM  A 203 (-3.5A)
None
SAM  A 203 (-3.2A)
None
 1.35A 2plwA-2plwA:
38.5		 2plwA-2plwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 SER A   4
ASP A  55
ASP A 113
 SAM  A 203 ( 4.5A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.6A)
 0.72A 2plwA-2plwA:
38.5		 2plwA-2plwA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 SER A  35
ASP A  55
ASP A 113
 SAM  A 203 (-2.4A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.6A)
 0.02A 2plwA-2plwA:
38.5		 2plwA-2plwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 6 LEU A  10
LEU A  13
ILE A  40
ARG A  43
 None
 1.10A 2rlfB-2plwA:
undetectable
2rlfC-2plwA:
undetectable		 2rlfB-2plwA:
12.06
2rlfC-2plwA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 7 VAL A 152
SER A 112
THR A 133
LEU A 132
 None
None
None
SAM  A 203 (-4.9A)
 1.22A 3arrA-2plwA:
undetectable		 3arrA-2plwA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		6 / 12 ALA A   6
GLY A  30
PRO A  33
GLY A  34
ILE A 136
ALA A 114
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
None
SAM  A 203 (-3.6A)
 1.38A 3douA-2plwA:
25.4		 3douA-2plwA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		7 / 12 ALA A   6
GLY A  30
PRO A  33
GLY A  34
TRP A  36
ALA A 114
LYS A 153
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-3.6A)
SAM  A 203 ( 4.1A)
 0.41A 3douA-2plwA:
25.4		 3douA-2plwA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		6 / 12 ALA A   6
GLY A  30
PRO A  33
GLY A  34
TRP A  36
ILE A  72
 SAM  A 203 (-3.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-4.4A)
 0.66A 3douA-2plwA:
25.4		 3douA-2plwA:
31.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		7 / 12 SER A   4
GLY A  30
PRO A  33
GLY A  34
TRP A  36
ASP A  55
ASP A 113
 SAM  A 203 ( 4.5A)
SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.6A)
SAM  A 203 (-3.8A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.6A)
 0.43A 4b17A-2plwA:
14.2		 4b17A-2plwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 8 GLY A 198
LEU A 167
ARG A 199
PHE A 171
 None
 1.08A 4m5mA-2plwA:
undetectable		 4m5mA-2plwA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		4 / 5 GLY A 169
ARG A 199
GLY A 198
GLU A 141
 None
 1.17A 4z2eB-2plwA:
undetectable
4z2eC-2plwA:
2.4		 4z2eB-2plwA:
17.01
4z2eC-2plwA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 GLY A  30
PRO A  33
LYS A  57
GLU A  71
VAL A 116
 SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-3.2A)
SAM  A 203 (-4.9A)
None
 0.69A 5x6yA-2plwA:
8.7		 5x6yA-2plwA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 GLY A  30
PRO A  33
ASP A  55
LYS A  57
GLU A  71
 SAM  A 203 (-3.4A)
SAM  A 203 (-3.5A)
SAM  A 203 (-2.8A)
SAM  A 203 (-3.2A)
SAM  A 203 (-4.9A)
 0.69A 5x6yC-2plwA:
undetectable		 5x6yC-2plwA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		3 / 3 TYR A 166
HIS A 138
MET A 140
 None
 1.14A 6af6A-2plwA:
undetectable		 6af6A-2plwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 2plw RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE
(Plasmodium
falciparum) 		5 / 12 PRO A  61
ILE A  68
VAL A  65
LEU A  98
LEU A  27
 None
 1.03A 6b52A-2plwA:
undetectable		 6b52A-2plwA:
21.62