SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.09A 1dyiA-2pmiA:
undetectable		 1dyiA-2pmiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  50
GLU A  53
LEU A  80
LEU A  40
 None
AGS  A3001 ( 4.8A)
None
None
 0.89A 1ereE-2pmiA:
undetectable		 1ereE-2pmiA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  50
GLU A  53
LEU A  80
LEU A  40
 None
AGS  A3001 ( 4.8A)
None
None
 0.87A 1ereF-2pmiA:
undetectable		 1ereF-2pmiA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.04A 1qzfA-2pmiA:
undetectable		 1qzfA-2pmiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.04A 1qzfB-2pmiA:
undetectable		 1qzfB-2pmiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.04A 1qzfC-2pmiA:
undetectable		 1qzfC-2pmiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.03A 1qzfD-2pmiA:
undetectable		 1qzfD-2pmiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.04A 1qzfE-2pmiA:
undetectable		 1qzfE-2pmiA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 180
VAL A 179
SER A 194
VAL A 169
LEU A 154
 None
 1.44A 1rk3A-2pmiA:
undetectable		 1rk3A-2pmiA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 CYH A 197
LEU A 199
ALA A 200
LEU A 258
ILE A 221
 None
 1.07A 1s9pC-2pmiA:
undetectable		 1s9pC-2pmiA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  34
LYS A  36
GLU A  53
MET A  57
VAL A  66
PHE A  84
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
AGS  A3001 ( 4.5A)
None
 0.81A 2gqgA-2pmiA:
23.3		 2gqgA-2pmiA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J7X_A_ESTA1454_1
(ESTROGEN RECEPTOR
BETA)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 139
LEU A 140
ILE A  65
GLY A 120
LEU A 121
 None
 1.15A 2j7xA-2pmiA:
undetectable		 2j7xA-2pmiA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 278
GLY A 226
ASP A 223
LEU A 254
LEU A 258
 None
 0.81A 2nxeA-2pmiA:
2.3		 2nxeA-2pmiA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		3 / 3 THR A 237
ASP A 283
SER A 189
 None
 0.83A 2nxeA-2pmiA:
2.3		 2nxeA-2pmiA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		3 / 3 THR A 237
ASP A 283
SER A 189
 None
 0.81A 2nxeB-2pmiA:
2.8		 2nxeB-2pmiA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.11A 2oipA-2pmiA:
undetectable		 2oipA-2pmiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.12A 2oipD-2pmiA:
undetectable		 2oipD-2pmiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.10A 2oipE-2pmiA:
undetectable		 2oipE-2pmiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XP2_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 9 VAL A  21
ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.72A 2xp2A-2pmiA:
21.5		 2xp2A-2pmiA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 149
ASP A 191
TRP A 296
HIS A 294
 None
 1.21A 2y69C-2pmiA:
1.9
2y69N-2pmiA:
undetectable
2y69P-2pmiA:
2.0		 2y69C-2pmiA:
20.30
2y69N-2pmiA:
18.86
2y69P-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 8 ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.63A 2yfxA-2pmiA:
21.3		 2yfxA-2pmiA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 139
LEU A 140
ILE A  65
GLY A 120
LEU A 121
 None
 1.13A 2yjaB-2pmiA:
undetectable		 2yjaB-2pmiA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 4 VAL A 169
ASP A 151
LEU A 139
ARG A 175
 None
AGS  A3001 (-2.8A)
None
None
 1.24A 2ziaA-2pmiA:
undetectable		 2ziaA-2pmiA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 12 ALA A  34
LYS A  36
GLU A  53
MET A  57
VAL A  66
MET A  85
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
None
None
 0.66A 2zvaA-2pmiA:
23.5		 2zvaA-2pmiA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.17A 3abmA-2pmiA:
undetectable
3abmC-2pmiA:
1.9
3abmP-2pmiA:
2.0		 3abmA-2pmiA:
18.86
3abmC-2pmiA:
20.30
3abmP-2pmiA:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 154
MET A  57
ILE A 198
ASP A  88
 None
 1.44A 3hecA-2pmiA:
23.4		 3hecA-2pmiA:
32.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.11A 3hj3B-2pmiA:
undetectable		 3hj3B-2pmiA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_A_B49A1_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 11 ALA A  34
LYS A  36
VAL A  66
PHE A  82
PHE A  84
MET A  85
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
AGS  A3001 ( 4.5A)
None
None
 0.65A 3miyA-2pmiA:
21.8		 3miyA-2pmiA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIY_B_B49B2_1
(TYROSINE-PROTEIN
KINASE ITK/TSK)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 9 ALA A  34
LYS A  36
PHE A  82
PHE A  84
MET A  85
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
AGS  A3001 ( 4.5A)
None
None
 0.53A 3miyB-2pmiA:
21.7		 3miyB-2pmiA:
29.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 274
HIS A 275
MET A 271
 None
 0.65A 3thrD-2pmiA:
undetectable		 3thrD-2pmiA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 9 ALA A  34
VAL A  66
PHE A  82
PHE A  84
ASP A  88
LEU A 140
 AGS  A3001 (-3.5A)
None
None
AGS  A3001 ( 4.5A)
None
None
 0.70A 3ti1A-2pmiA:
29.9		 3ti1A-2pmiA:
53.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 9 VAL A  66
PHE A  82
ASP A  88
LEU A 140
ASP A 151
 None
None
None
None
AGS  A3001 (-2.8A)
 0.82A 3ti1A-2pmiA:
29.9		 3ti1A-2pmiA:
53.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 186
SER A 167
ASP A 191
ILE A 129
 None
 1.28A 3uj7B-2pmiA:
undetectable		 3uj7B-2pmiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 180
VAL A 179
SER A 194
VAL A 169
LEU A 154
 None
 1.39A 3vt7A-2pmiA:
undetectable		 3vt7A-2pmiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.23A 3wg7A-2pmiA:
undetectable
3wg7C-2pmiA:
1.9
3wg7P-2pmiA:
2.0		 3wg7A-2pmiA:
18.86
3wg7C-2pmiA:
20.30
3wg7P-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 149
ASP A 191
TRP A 296
HIS A 294
 None
 1.23A 3wg7C-2pmiA:
1.9
3wg7N-2pmiA:
undetectable
3wg7P-2pmiA:
2.0		 3wg7C-2pmiA:
20.30
3wg7N-2pmiA:
18.86
3wg7P-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.47A 3zbfA-2pmiA:
23.2		 3zbfA-2pmiA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J26_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 139
LEU A 140
ILE A  65
GLY A 120
LEU A 121
 None
 1.17A 4j26A-2pmiA:
undetectable		 4j26A-2pmiA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_B_8PRB601_1
(RHODOPSIN KINASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 8 ALA A  34
LYS A  36
MET A  85
ASP A  88
LEU A 140
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
None
 0.91A 4l9iB-2pmiA:
23.5		 4l9iB-2pmiA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 7 ALA A  34
ASP A  88
ASN A 138
LEU A 140
ASP A 151
 AGS  A3001 (-3.5A)
None
AGS  A3001 (-3.9A)
None
AGS  A3001 (-2.8A)
 0.65A 4ogrE-2pmiA:
31.8		 4ogrE-2pmiA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.08A 4qlgB-2pmiA:
undetectable		 4qlgB-2pmiA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 12 VAL A  21
ALA A  34
LYS A  36
GLU A  53
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
AGS  A3001 (-2.8A)
 1.07A 4r7iA-2pmiA:
20.1		 4r7iA-2pmiA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 253
LEU A 254
THR A 262
ILE A 203
LEU A 270
 None
 1.14A 4x5gA-2pmiA:
undetectable		 4x5gA-2pmiA:
18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 176
LEU A 180
MET A 181
LEU A 239
 None
 1.13A 4xoyA-2pmiA:
11.8		 4xoyA-2pmiA:
33.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 176
LEU A 180
MET A 181
LEU A 239
 None
 1.19A 4xp3A-2pmiA:
27.2		 4xp3A-2pmiA:
33.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		5 / 12 ALA A  34
LYS A  36
GLY A 150
ASP A 151
PHE A 152
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
AGS  A3001 (-2.8A)
None
 0.91A 4xv2B-2pmiA:
22.0		 4xv2B-2pmiA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAA_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 9 VAL A  21
ALA A  34
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
None
None
None
AGS  A3001 (-2.8A)
 0.70A 5aaaA-2pmiA:
15.1		 5aaaA-2pmiA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 10 VAL A  21
ALA A  34
LYS A  36
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
None
AGS  A3001 (-2.8A)
 0.82A 5aabA-2pmiA:
15.1		 5aabA-2pmiA:
25.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		7 / 10 VAL A  21
ALA A  34
LYS A  36
MET A  85
LEU A 140
GLY A 150
ASP A 151
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
None
None
None
AGS  A3001 (-2.8A)
 0.91A 5aacA-2pmiA:
21.3		 5aacA-2pmiA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.20A 5b1aA-2pmiA:
undetectable
5b1aC-2pmiA:
2.0
5b1aP-2pmiA:
2.0		 5b1aA-2pmiA:
18.86
5b1aC-2pmiA:
20.30
5b1aP-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.24A 5b3sA-2pmiA:
1.5
5b3sC-2pmiA:
2.0
5b3sP-2pmiA:
2.0		 5b3sA-2pmiA:
18.86
5b3sC-2pmiA:
20.30
5b3sP-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  80
ILE A  54
PRO A  47
LEU A  40
 None
 1.25A 5eb3A-2pmiA:
undetectable		 5eb3A-2pmiA:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 12 VAL A  21
ALA A  34
VAL A  66
PHE A  82
ASP A  88
LEU A 140
 AGS  A3001 (-4.4A)
AGS  A3001 (-3.5A)
None
None
None
None
 0.91A 5l2tA-2pmiA:
14.5		 5l2tA-2pmiA:
41.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		6 / 12 ALA A  34
LYS A  36
GLU A  53
VAL A  66
LEU A  80
GLY A 150
 AGS  A3001 (-3.5A)
AGS  A3001 (-3.4A)
AGS  A3001 ( 4.8A)
None
None
None
 0.93A 5vcvA-2pmiA:
24.2		 5vcvA-2pmiA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 149
ASP A 191
TRP A 296
HIS A 294
 None
 1.19A 5w97C-2pmiA:
1.9
5w97a-2pmiA:
undetectable
5w97c-2pmiA:
1.9		 5w97C-2pmiA:
20.30
5w97a-2pmiA:
18.86
5w97c-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.19A 5wauA-2pmiA:
undetectable
5wauC-2pmiA:
1.9
5wauc-2pmiA:
1.9		 5wauA-2pmiA:
18.86
5wauC-2pmiA:
20.30
5wauc-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 149
ASP A 191
TRP A 296
HIS A 294
 None
 1.17A 5wauC-2pmiA:
2.0
5waua-2pmiA:
undetectable
5wauc-2pmiA:
2.0		 5wauC-2pmiA:
20.30
5waua-2pmiA:
18.86
5wauc-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.21A 5xdqA-2pmiA:
undetectable
5xdqC-2pmiA:
2.0
5xdqP-2pmiA:
2.0		 5xdqA-2pmiA:
18.86
5xdqC-2pmiA:
20.30
5xdqP-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.20A 5z84A-2pmiA:
undetectable
5z84C-2pmiA:
2.0
5z84P-2pmiA:
2.0		 5z84A-2pmiA:
18.86
5z84C-2pmiA:
20.30
5z84P-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 149
ASP A 191
TRP A 296
HIS A 294
 None
 1.23A 5z84C-2pmiA:
2.0
5z84N-2pmiA:
undetectable
5z84P-2pmiA:
2.0		 5z84C-2pmiA:
20.30
5z84N-2pmiA:
18.86
5z84P-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.22A 5z85A-2pmiA:
1.5
5z85C-2pmiA:
1.9
5z85P-2pmiA:
2.0		 5z85A-2pmiA:
18.86
5z85C-2pmiA:
20.30
5z85P-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 149
ASP A 191
TRP A 296
HIS A 294
 None
 1.22A 5z85C-2pmiA:
1.9
5z85N-2pmiA:
undetectable
5z85P-2pmiA:
2.0		 5z85C-2pmiA:
20.30
5z85N-2pmiA:
18.86
5z85P-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.20A 5z86A-2pmiA:
undetectable
5z86C-2pmiA:
2.0
5z86P-2pmiA:
2.0		 5z86A-2pmiA:
18.86
5z86C-2pmiA:
20.30
5z86P-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.22A 5zcoA-2pmiA:
undetectable
5zcoC-2pmiA:
undetectable
5zcoP-2pmiA:
2.0		 5zcoA-2pmiA:
18.86
5zcoC-2pmiA:
20.30
5zcoP-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.22A 5zcpA-2pmiA:
undetectable
5zcpC-2pmiA:
2.0
5zcpP-2pmiA:
2.0		 5zcpA-2pmiA:
18.86
5zcpC-2pmiA:
20.30
5zcpP-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 191
TRP A 296
HIS A 294
LEU A 149
 None
 1.22A 5zcqA-2pmiA:
1.7
5zcqC-2pmiA:
2.0
5zcqP-2pmiA:
2.0		 5zcqA-2pmiA:
18.86
5zcqC-2pmiA:
20.30
5zcqP-2pmiA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA820_0
(GEPHYRIN)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 230
PRO A 228
THR A 227
MET A 181
 None
 1.17A 6fgdA-2pmiA:
undetectable		 6fgdA-2pmiA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2pmi CYCLIN-DEPENDENT
PROTEIN KINASE PHO85
(Saccharomyces
cerevisiae) 		4 / 7 ARG A  67
TYR A  69
GLU A  83
GLU A  63
 None
 1.06A 6mn5E-2pmiA:
undetectable		 6mn5E-2pmiA:
14.43