SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 HIS A  45
SER A  38
ASP A  39
PHE A  64
 ZN  A 500 (-3.1A)
ZN  A 500 ( 4.6A)
None
None
 1.21A 1ismB-2pmpA:
undetectable		 1ismB-2pmpA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 ALA A 151
LEU A 132
ILE A  28
ILE A  26
GLY A  25
 None
 0.90A 1qknA-2pmpA:
undetectable		 1qknA-2pmpA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 11 ALA A 125
LEU A  43
ASN A 131
LEU A 119
ARG A 116
 None
 1.07A 2ceoA-2pmpA:
undetectable		 2ceoA-2pmpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		3 / 3 HIS A  45
ILE A  80
LEU A  52
 ZN  A 500 (-3.1A)
None
None
 0.74A 2kceA-2pmpA:
undetectable		 2kceA-2pmpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 5 SER A  38
GLY A  40
ASP A 141
ASP A  11
 ZN  A 500 ( 4.6A)
None
PO4  A 701 (-3.4A)
ZN  A 500 (-2.3A)
 1.08A 2oxtB-2pmpA:
undetectable		 2oxtB-2pmpA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 ALA A 125
LEU A  43
LEU A  97
LEU A 119
ARG A 116
 None
 1.13A 2xn7A-2pmpA:
undetectable
2xn7B-2pmpA:
undetectable		 2xn7A-2pmpA:
20.14
2xn7B-2pmpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		3 / 3 LEU A  57
PRO A  58
LEU A  52
 None
 0.56A 3hcrA-2pmpA:
undetectable		 3hcrA-2pmpA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		4 / 7 VAL A  42
PHE A  10
LEU A 143
ILE A 102
 None
None
PO4  A 701 (-4.7A)
None
 0.93A 3rfmA-2pmpA:
undetectable		 3rfmA-2pmpA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  86
ALA A  83
GLU A  82
GLY A 124
LEU A 123
 None
 1.12A 4pxmA-2pmpA:
undetectable		 4pxmA-2pmpA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 11 LEU A  86
ALA A  83
GLU A  82
GLY A 124
LEU A 123
 None
 1.09A 4pxmB-2pmpA:
undetectable		 4pxmB-2pmpA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 9 ALA A 125
LEU A  43
ASN A 131
LEU A 119
ARG A 116
 None
 1.15A 4x30A-2pmpA:
undetectable		 4x30A-2pmpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 10 LEU A  86
ALA A  83
GLU A  82
GLY A 124
LEU A 123
 None
 1.13A 5dx3A-2pmpA:
undetectable		 5dx3A-2pmpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXG_B_ESTB601_1
(ESTROGEN RECEPTOR)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 11 LEU A  86
ALA A  83
GLU A  82
GLY A 124
LEU A 123
 None
 1.07A 5dxgB-2pmpA:
undetectable		 5dxgB-2pmpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  86
ALA A  83
GLU A  82
GLY A 124
LEU A 123
 None
 1.12A 5gs4A-2pmpA:
undetectable		 5gs4A-2pmpA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  86
ALA A  83
GLU A  82
GLY A 124
LEU A 123
 None
 0.99A 5gtrA-2pmpA:
undetectable		 5gtrA-2pmpA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_2
(PROTEASE PR5-SQV)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 11 ALA A 151
ASP A  11
GLY A  24
ILE A 115
ILE A 149
 None
ZN  A 500 (-2.3A)
None
None
None
 1.03A 5kr2B-2pmpA:
undetectable		 5kr2B-2pmpA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE
(Arabidopsis
thaliana) 		5 / 12 ALA A  83
LEU A  52
ILE A  60
GLY A   7
LEU A  97
 None
None
C5P  A 700 (-4.9A)
None
None
 1.06A 5m24A-2pmpA:
undetectable		 5m24A-2pmpA:
23.35