SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pmz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_ACTA294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 5 ILE C 241
LEU C 138
ALA C 141
GLU C 145
 None
 1.29A 1xvaA-2pmzC:
undetectable
1xvaB-2pmzC:
undetectable		 1xvaA-2pmzC:
21.34
1xvaB-2pmzC:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
(Sulfolobus
solfataricus) 		4 / 5 LEU K  92
ILE K  32
ILE K  76
GLY K  72
 None
 0.89A 3bufA-2pmzK:
undetectable		 3bufA-2pmzK:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 4 ILE C 297
GLN C 304
ILE C 310
LEU C 102
 None
 1.31A 3dzyD-2pmzC:
undetectable		 3dzyD-2pmzC:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		5 / 11 ALA C 289
ASN C 275
GLU C 281
VAL C 326
ILE C 110
 None
 1.24A 3fl9C-2pmzC:
undetectable		 3fl9C-2pmzC:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 7 LEU C  54
GLU C  58
ILE C  51
VAL C  17
 None
 1.08A 4tvtA-2pmzC:
undetectable		 4tvtA-2pmzC:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
(Sulfolobus
solfataricus) 		4 / 8 ILE C 250
ARG C 239
LEU C 126
ILE C 124
 None
 0.79A 4v04A-2pmzC:
undetectable		 4v04A-2pmzC:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT L
(Sulfolobus
solfataricus) 		5 / 12 ILE L  63
ILE L  28
LEU L  32
VAL L  38
ILE L  57
 None
 0.95A 5mugA-2pmzL:
undetectable		 5mugA-2pmzL:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_1
(TETRACYCLINE
DESTRUCTASE TET(50))		 2pmz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT K
(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		4 / 5 ASP C 318
ARG C 322
ARG C 290
LEU K  13
 None
 1.03A 5tuiB-2pmzC:
2.5		 5tuiB-2pmzC:
22.97