SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pn0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB
(Nitrosomonas
europaea) 		5 / 12 GLY A  86
ASP A  83
PRO A  94
VAL A  95
ILE A  89
 None
 1.09A 1hsgB-2pn0A:
undetectable		 1hsgB-2pn0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_B_URFB999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB
(Nitrosomonas
europaea) 		4 / 7 ALA A  14
ILE A   9
ILE A  50
ASP A  46
 None
 0.88A 1upfB-2pn0A:
undetectable		 1upfB-2pn0A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB
(Nitrosomonas
europaea) 		4 / 8 PHE A  63
VAL A  95
GLY A  96
VAL A  55
 None
 0.77A 2a1mB-2pn0A:
undetectable		 2a1mB-2pn0A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB
(Nitrosomonas
europaea) 		4 / 8 PHE A  63
VAL A  95
GLY A  96
VAL A  55
 None
 0.74A 2a1oA-2pn0A:
undetectable		 2a1oA-2pn0A:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB
(Nitrosomonas
europaea) 		3 / 3 PHE A  63
LYS A  74
SER A  59
 None
OCS  A  73 ( 3.5A)
None
 1.35A 3tyeB-2pn0A:
undetectable		 3tyeB-2pn0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB
(Nitrosomonas
europaea) 		5 / 9 ILE A   7
GLU A  38
VAL A  95
LEU A  99
ILE A  89
 None
 1.31A 4r38C-2pn0A:
undetectable		 4r38C-2pn0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_C_08JC602_1
(CYTOCHROME P450 3A4)		 2pn0 PROKARYOTIC
TRANSCRIPTION
ELONGATION FACTOR
GREA/GREB
(Nitrosomonas
europaea) 		4 / 7 LEU A 102
ALA A  98
ILE A  89
LEU A  76
 None
 0.75A 5te8C-2pn0A:
undetectable		 5te8C-2pn0A:
14.41