SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pnm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		5 / 11 SER A 633
LEU A 636
THR A 655
ILE A 645
ILE A 563
 None
 1.13A 1pkvA-2pnmA:
undetectable
1pkvB-2pnmA:
undetectable		 1pkvA-2pnmA:
20.53
1pkvB-2pnmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		5 / 11 ILE A 563
SER A 633
LEU A 636
THR A 655
ILE A 645
 None
 1.14A 1pkvA-2pnmA:
undetectable
1pkvB-2pnmA:
undetectable		 1pkvA-2pnmA:
20.53
1pkvB-2pnmA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		5 / 12 PRO A 544
ILE A 706
GLY A 637
ILE A 686
GLU A 646
 None
 1.13A 1sg9A-2pnmA:
undetectable		 1sg9A-2pnmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		5 / 11 LEU A 560
ALA A 674
ILE A 668
GLY A 687
ILE A 686
 None
 1.05A 2o4pA-2pnmA:
undetectable		 2o4pA-2pnmA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		4 / 8 GLN A 635
VAL A 589
GLY A 593
GLY A 591
 None
 0.77A 2vinA-2pnmA:
undetectable		 2vinA-2pnmA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		4 / 8 GLY A 637
VAL A 543
ILE A 596
VAL A 642
 None
 0.81A 3fi0I-2pnmA:
undetectable		 3fi0I-2pnmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		4 / 7 TYR A 605
VAL A 589
PHE A 582
VAL A 642
 None
 0.94A 3zjqA-2pnmA:
undetectable		 3zjqA-2pnmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		4 / 7 TYR A 605
VAL A 589
PHE A 582
VAL A 642
 None
 0.95A 3zjqB-2pnmA:
undetectable		 3zjqB-2pnmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		5 / 9 VAL A 545
VAL A 546
GLY A 631
SER A 633
ALA A 634
 None
 0.50A 4fwdA-2pnmA:
7.0		 4fwdA-2pnmA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_1
(PROTEASE)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		5 / 11 LEU A 560
ALA A 674
ILE A 668
GLY A 687
ILE A 686
 None
 0.99A 4njtA-2pnmA:
undetectable		 4njtA-2pnmA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		4 / 7 ILE A 564
ILE A 542
ILE A 613
LEU A 560
 None
 0.80A 5fukA-2pnmA:
undetectable
5fukB-2pnmA:
undetectable		 5fukA-2pnmA:
22.48
5fukB-2pnmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 2pnm PROTEASE VP4
(Infectious
pancreatic
necrosis
virus) 		5 / 11 ILE A 668
ILE A 665
VAL A 543
VAL A 545
LEU A 685
 None
 1.27A 5jkwA-2pnmA:
undetectable		 5jkwA-2pnmA:
16.60