SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
5 / 11 ALA A 180
LEU A 186
LEU A 177
LEU A 219
ALA A 225
ALA  A 180 ( 0.0A)
LEU  A 186 ( 0.5A)
LEU  A 177 ( 0.6A)
LEU  A 219 ( 0.6A)
ALA  A 225 ( 0.0A)
1.12A 1h9zA-2pnnA:
undetectable
1h9zA-2pnnA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
3 / 3 ASN A 301
PHE A 245
VAL A 294
ASN  A 301 ( 0.6A)
PHE  A 245 ( 1.3A)
VAL  A 294 ( 0.5A)
0.81A 1kijA-2pnnA:
undetectable
1kijA-2pnnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
4 / 6 GLY A 344
VAL A 292
ALA A 340
SER A 342
GLY  A 344 ( 0.0A)
VAL  A 292 ( 0.6A)
ALA  A 340 ( 0.0A)
SER  A 342 ( 0.0A)
1.02A 1p6kA-2pnnA:
undetectable
1p6kA-2pnnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
3 / 3 LEU A 219
LEU A 205
MET A 162
LEU  A 219 ( 0.6A)
LEU  A 205 ( 0.5A)
LEU  A 216 ( 3.6A)
0.79A 1ya3B-2pnnA:
undetectable
1ya3B-2pnnA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NPN_A_SAMA4633_0
(PUTATIVE COBALAMIN
SYNTHESIS RELATED
PROTEIN)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
5 / 9 GLY A 316
LEU A 313
TYR A 309
LEU A 291
THR A 286
GLY  A 316 ( 0.0A)
LEU  A 313 ( 0.5A)
TYR  A 309 ( 1.3A)
LEU  A 291 ( 0.6A)
THR  A 286 ( 0.8A)
1.03A 2npnA-2pnnA:
undetectable
2npnA-2pnnA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
4 / 7 SER A 343
ALA A 295
VAL A 305
ILE A 352
SER  A 343 ( 0.0A)
ALA  A 295 ( 0.0A)
VAL  A 305 ( 0.6A)
ILE  A 352 ( 0.6A)
0.77A 3a2qA-2pnnA:
undetectable
3a2qA-2pnnA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
5 / 12 THR A 156
ILE A 173
ILE A 207
ALA A 208
LEU A 165
THR  A 156 ( 0.8A)
ILE  A 173 ( 0.6A)
ILE  A 207 ( 0.7A)
ALA  A 208 ( 0.0A)
LEU  A 165 ( 0.6A)
1.18A 3a51E-2pnnA:
undetectable
3a51E-2pnnA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
5 / 12 PHE A 189
LEU A 175
ALA A 174
LEU A 216
GLY A 168
PHE  A 189 ( 1.3A)
LEU  A 175 ( 0.5A)
ALA  A 174 ( 0.0A)
LEU  A 216 ( 0.5A)
GLY  A 168 ( 0.0A)
1.03A 4dm8B-2pnnA:
undetectable
4dm8B-2pnnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
5 / 12 LEU A 268
ALA A 275
THR A 258
ALA A 256
ILE A 312
LEU  A 268 ( 0.6A)
ALA  A 275 ( 0.0A)
THR  A 258 ( 0.8A)
ALA  A 256 ( 0.0A)
ILE  A 312 ( 0.7A)
1.03A 5itzB-2pnnA:
1.5
5itzB-2pnnA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)
2pnn TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 1

(Rattus
norvegicus)
4 / 4 ASN A 125
SER A 116
ALA A 120
VAL A 121
ASN  A 125 ( 0.6A)
SER  A 116 ( 0.0A)
ALA  A 120 ( 0.0A)
VAL  A 121 ( 0.6A)
1.39A 5nm5A-2pnnA:
undetectable
5nm5A-2pnnA:
20.91