SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 205
LEU A 125
ILE A 160
LEU A 165
ARG A 168
 None
 1.29A 1dreA-2pnwA:
undetectable		 1dreA-2pnwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		4 / 4 GLY A 169
LEU A 170
GLY A 167
ARG A 168
 None
 1.42A 1j7kA-2pnwA:
undetectable		 1j7kA-2pnwA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 11 ALA A 205
LEU A 125
ILE A 160
LEU A 165
ARG A 168
 None
 1.21A 1jomA-2pnwA:
undetectable		 1jomA-2pnwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		3 / 3 ASP A  22
PHE A  77
ASN A  68
 None
 0.80A 1sg9B-2pnwA:
undetectable		 1sg9B-2pnwA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_A_TPFA2472_1
(CYTOCHROME P450 121)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 11 THR A 349
VAL A 350
THR A 337
ALA A 343
GLN A 233
 None
 1.31A 2ij7A-2pnwA:
0.0		 2ij7A-2pnwA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_B_TPFB2470_1
(CYTOCHROME P450 121)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 9 THR A 349
VAL A 350
THR A 337
ALA A 343
GLN A 233
 None
 1.35A 2ij7B-2pnwA:
0.0		 2ij7B-2pnwA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_F_TPFF2474_1
(CYTOCHROME P450 121)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 10 THR A 349
VAL A 350
THR A 337
ALA A 343
GLN A 233
 None
 1.39A 2ij7F-2pnwA:
0.0		 2ij7F-2pnwA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 12 SER A  93
ASP A 334
GLY A 333
VAL A 350
ALA A 347
 None
 1.05A 2kceA-2pnwA:
undetectable		 2kceA-2pnwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 12 SER A  93
ASP A 334
GLY A 333
VAL A 350
ALA A 347
 None
 1.15A 2kceB-2pnwA:
undetectable		 2kceB-2pnwA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 291
ALA A 286
GLY A 333
GLY A 329
VAL A  96
 None
 1.03A 2okcA-2pnwA:
undetectable		 2okcA-2pnwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 12 ILE A 291
ALA A 286
GLY A 333
GLY A 329
VAL A  96
 None
 1.03A 2okcB-2pnwA:
undetectable		 2okcB-2pnwA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2001_1
(SERUM ALBUMIN)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 12 PRO A 303
ILE A  86
HIS A 292
ARG A 332
GLY A 329
 None
 1.41A 2vufB-2pnwA:
0.0		 2vufB-2pnwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		3 / 3 VAL A 179
LYS A 178
HIS A 252
 None
 0.82A 3elzA-2pnwA:
undetectable		 3elzA-2pnwA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		4 / 5 ASN A 253
THR A 323
SER A 325
ARG A 289
 None
 1.45A 3hlwB-2pnwA:
undetectable		 3hlwB-2pnwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		5 / 12 ALA A 205
LEU A 125
ILE A 160
LEU A 165
ARG A 168
 None
 1.19A 3ql0A-2pnwA:
undetectable		 3ql0A-2pnwA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA193_1
(DIHYDROFOLATE
REDUCTASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		4 / 5 ASP A 221
LEU A 220
ILE A 215
PRO A 214
 None
 1.04A 3s3vA-2pnwA:
undetectable		 3s3vA-2pnwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		4 / 8 GLY A 209
ARG A 121
PHE A 137
ILE A 128
 None
 0.69A 4j4vC-2pnwA:
undetectable		 4j4vC-2pnwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		4 / 6 ILE A 215
ILE A 230
SER A 231
PHE A 183
 None
 0.93A 4m51A-2pnwA:
undetectable		 4m51A-2pnwA:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		4 / 5 GLY A 197
ASP A 196
GLU A 105
VAL A 113
 None
 1.14A 4nkvD-2pnwA:
undetectable		 4nkvD-2pnwA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		4 / 7 ILE A 202
LEU A 104
ALA A 173
ILE A 172
 None
 0.72A 4y03A-2pnwA:
undetectable		 4y03A-2pnwA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		3 / 3 VAL A  10
LEU A 285
MET A 318
 None
 0.86A 5ikrA-2pnwA:
undetectable		 5ikrA-2pnwA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 2pnw MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE
(Agrobacterium
fabrum) 		3 / 3 ILE A  50
THR A  51
PRO A 361
 None
 0.63A 6ncsA-2pnwA:
undetectable		 6ncsA-2pnwA:
20.74