SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pny'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_D_H4BD1006_1
(HYPOTHETICAL PROTEIN
PH0634)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 10 HIS A  88
HIS A  51
HIS A  40
GLU A 115
ASP A  83
 MN  A 229 ( 3.2A)
MN  A 229 (-3.3A)
MN  A 229 (-3.3A)
CA  A 228 ( 2.6A)
None
 1.26A 2dttD-2pnyA:
undetectable
2dttF-2pnyA:
undetectable		 2dttD-2pnyA:
20.08
2dttF-2pnyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB928_0
(FERROCHELATASE)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 12 LEU A 116
LEU A  66
ARG A 111
GLN A  13
LEU A 197
 None
None
POP  A 230 (-3.8A)
None
None
 1.29A 2qd4B-2pnyA:
undetectable		 2qd4B-2pnyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		4 / 5 ARG A 111
ALA A 114
ASP A 164
GLU A 167
 POP  A 230 (-3.8A)
None
None
POP  A 230 ( 4.3A)
 1.15A 2xrzA-2pnyA:
undetectable		 2xrzA-2pnyA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		4 / 7 GLY A 145
HIS A 136
HIS A 135
HIS A  51
 None
None
GOL  A 233 (-3.7A)
MN  A 229 (-3.3A)
 0.97A 3ai8A-2pnyA:
undetectable		 3ai8A-2pnyA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 9 LEU A 112
ILE A 118
GLY A 117
SER A  86
GLU A 167
 None
None
None
POP  A 230 ( 2.7A)
POP  A 230 ( 4.3A)
 1.14A 3ai9X-2pnyA:
undetectable		 3ai9X-2pnyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		3 / 3 HIS A 147
GLU A 146
HIS A  40
 None
MN  A 229 (-1.9A)
MN  A 229 (-3.3A)
 0.68A 3ba0A-2pnyA:
undetectable		 3ba0A-2pnyA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 12 LEU A  66
ILE A  65
VAL A 215
LEU A 154
VAL A 129
 None
 0.86A 4gc9A-2pnyA:
undetectable		 4gc9A-2pnyA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 9 LEU A  66
VAL A 159
VAL A 155
LEU A 161
TYR A 173
 None
 1.46A 4q0bC-2pnyA:
0.0		 4q0bC-2pnyA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		4 / 7 ALA A  53
TYR A 151
VAL A  24
HIS A  88
 MN  A 229 ( 4.6A)
None
None
MN  A 229 ( 3.2A)
 1.13A 5ecnA-2pnyA:
undetectable		 5ecnA-2pnyA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 11 LEU A  66
VAL A 159
VAL A 155
LEU A 161
TYR A 173
 None
 1.48A 5hbmA-2pnyA:
undetectable		 5hbmA-2pnyA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		3 / 3 THR A 194
THR A 168
LEU A  66
 None
 0.32A 5m66D-2pnyA:
undetectable		 5m66D-2pnyA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		5 / 11 HIS A 136
HIS A  40
HIS A  51
VAL A  23
HIS A 147
 None
MN  A 229 (-3.3A)
MN  A 229 (-3.3A)
None
None
 1.49A 5z0mA-2pnyA:
undetectable
5z0mB-2pnyA:
undetectable		 5z0mA-2pnyA:
15.04
5z0mB-2pnyA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		4 / 8 TYR A 173
LEU A 161
VAL A 159
VAL A 155
 None
 1.07A 6cp4A-2pnyA:
undetectable		 6cp4A-2pnyA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		4 / 5 ARG A 110
THR A 168
GLN A  68
ASP A  72
 None
 1.15A 6ectA-2pnyA:
undetectable		 6ectA-2pnyA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 2pny ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE
2
(Homo
sapiens) 		4 / 5 ARG A 110
THR A 168
GLN A  68
ASP A  72
 None
 1.26A 6ecxA-2pnyA:
undetectable		 6ecxA-2pnyA:
22.94