SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		3 / 3 GLU A 168
ILE A 167
ARG A  21
 None
 0.82A 1cd2A-2pnzA:
undetectable		 1cd2A-2pnzA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		5 / 12 ILE A 105
ALA A 163
GLY A 135
THR A 136
GLY A 140
 None
None
UDP  A 250 (-3.4A)
UDP  A 250 (-2.8A)
None
 1.06A 2y7hB-2pnzA:
undetectable		 2y7hB-2pnzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		5 / 12 ILE A 105
ALA A 163
GLY A 135
THR A 136
GLY A 140
 None
None
UDP  A 250 (-3.4A)
UDP  A 250 (-2.8A)
None
 1.06A 2y7hC-2pnzA:
undetectable		 2y7hC-2pnzA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		4 / 8 VAL A 129
GLY A 135
THR A 136
ALA A 139
 None
UDP  A 250 (-3.4A)
UDP  A 250 (-2.8A)
None
 0.67A 3aruA-2pnzA:
undetectable		 3aruA-2pnzA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		4 / 4 GLY A 222
VAL A 226
GLY A 135
THR A 136
 MPD  A 252 ( 4.2A)
None
UDP  A 250 (-3.4A)
UDP  A 250 (-2.8A)
 0.88A 3ib2A-2pnzA:
undetectable		 3ib2A-2pnzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		5 / 12 ARG A  21
GLY A  48
SER A  85
GLU A 179
ALA A 134
 None
None
None
None
UDP  A 250 (-4.1A)
 1.10A 3kkzA-2pnzA:
undetectable		 3kkzA-2pnzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		5 / 12 ARG A  21
GLY A  48
SER A  85
GLU A 179
ALA A 134
 None
None
None
None
UDP  A 250 (-4.1A)
 1.10A 3kkzB-2pnzA:
undetectable		 3kkzB-2pnzA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		4 / 4 PRO A  64
LEU A  62
ILE A  74
ARG A  69
 None
 1.23A 3w1wA-2pnzA:
undetectable		 3w1wA-2pnzA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		3 / 3 TYR A  79
THR A 136
GLU A 100
 None
UDP  A 250 (-2.8A)
None
 0.70A 4df3A-2pnzA:
undetectable		 4df3A-2pnzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		3 / 3 TYR A  79
THR A 136
GLU A 100
 None
UDP  A 250 (-2.8A)
None
 0.70A 4df3B-2pnzA:
undetectable		 4df3B-2pnzA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		4 / 7 LEU A 201
ALA A 219
VAL A 138
ILE A 167
 None
 0.95A 4eyrA-2pnzA:
undetectable		 4eyrA-2pnzA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		4 / 4 PRO A  64
LEU A  62
ILE A  74
ARG A  72
 None
 1.39A 4f4dA-2pnzA:
undetectable		 4f4dA-2pnzA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		5 / 12 ASP A  12
GLY A 183
GLU A 211
ILE A 171
ASP A  19
 None
MPD  A 251 (-4.5A)
None
None
None
 1.21A 4xe5A-2pnzA:
undetectable		 4xe5A-2pnzA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1
(Pyrococcus
abyssi) 		3 / 3 VAL A 172
TYR A  24
GLU A 179
 None
 0.86A 5zmqD-2pnzA:
undetectable
5zmqE-2pnzA:
undetectable		 5zmqD-2pnzA:
22.27
5zmqE-2pnzA:
11.64