SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2po2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 8 ALA B  46
GLU B  47
HIS B 141
LEU B  60
 None
 0.92A 1ereE-2po2B:
undetectable		 1ereE-2po2B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 8 ALA B  46
GLU B  47
HIS B 141
LEU B  60
 None
 0.92A 1ereF-2po2B:
undetectable		 1ereF-2po2B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 11 LEU B 187
VAL B 189
ILE B 192
ILE B 158
VAL B 269
 None
 1.33A 1gx9A-2po2B:
undetectable		 1gx9A-2po2B:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 12 ALA B 159
VAL B 194
GLY B 154
ILE B 153
ILE B  38
 None
 0.84A 1hshA-2po2B:
undetectable		 1hshA-2po2B:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 11 LEU B 120
GLU B 185
ALA B 164
LEU B 162
VAL B 136
 None
None
None
MPD  B 280 (-4.8A)
None
 1.22A 1ictA-2po2B:
undetectable
1ictC-2po2B:
undetectable		 1ictA-2po2B:
19.32
1ictC-2po2B:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 7 LEU B  54
ILE B 221
THR B 197
MET B 217
 None
 1.18A 1kglA-2po2B:
undetectable		 1kglA-2po2B:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		3 / 3 LYS B 220
ASP B 146
ASN B 148
 None
 1.11A 2bm9A-2po2B:
undetectable		 2bm9A-2po2B:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		3 / 3 MET B 125
VAL B 189
GLU B 185
 None
 0.71A 3c6gA-2po2B:
undetectable		 3c6gA-2po2B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 5 ASP B 208
SER B 210
GLY B 147
ASP B 151
 None
 1.14A 3w9tB-2po2B:
undetectable		 3w9tB-2po2B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 5 ASP B 208
SER B 210
GLY B 147
ASP B 151
 None
 1.15A 3w9tC-2po2B:
undetectable		 3w9tC-2po2B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 5 ASP B 208
SER B 210
GLY B 147
ASP B 151
 None
 1.15A 3w9tD-2po2B:
undetectable		 3w9tD-2po2B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 12 ILE B 158
ASN B 163
ILE B 155
VAL B  52
ILE B  36
 None
 0.92A 4ax8A-2po2B:
undetectable		 4ax8A-2po2B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 12 ILE B 158
ASN B 163
ILE B 155
VAL B  52
ILE B  36
 None
 0.89A 4azvA-2po2B:
undetectable		 4azvA-2po2B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 8 SER B 232
SER B 117
ILE B 158
GLU B 227
 None
None
None
MPD  B 280 (-4.1A)
 1.30A 4ms4A-2po2B:
undetectable		 4ms4A-2po2B:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 12 LEU B 106
ASN B 148
ALA B  50
VAL B  59
VAL B  52
 None
 0.91A 4nkxB-2po2B:
undetectable		 4nkxB-2po2B:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 6 LEU B  54
ILE B 221
THR B 197
MET B 217
 None
 1.14A 5ljeA-2po2B:
undetectable		 5ljeA-2po2B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		3 / 3 THR B  57
THR B  93
LEU B 215
 None
 0.70A 5m66D-2po2B:
undetectable		 5m66D-2po2B:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 12 LEU B 161
PRO B 193
SER B 232
ASP B 111
GLY B 113
 None
 1.21A 5nnaA-2po2B:
undetectable		 5nnaA-2po2B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 12 LEU B 161
PRO B 193
SER B 232
ASP B 111
GLY B 113
 None
 1.19A 5nnaB-2po2B:
undetectable		 5nnaB-2po2B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 12 LEU B 161
PRO B 193
SER B 232
ASP B 111
GLY B 113
 None
 1.22A 5nnaD-2po2B:
undetectable		 5nnaD-2po2B:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		5 / 12 ALA B 164
GLY B  48
SER B  49
ASN B  83
GLU B  85
 None
 1.17A 5nwuA-2po2B:
undetectable		 5nwuA-2po2B:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 5 GLN B 235
THR B 222
HIS B 145
LEU B 106
 None
 1.27A 6aphA-2po2B:
undetectable		 6aphA-2po2B:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 5 GLN B 235
THR B 222
HIS B 145
LEU B 106
 None
 1.28A 6gbnB-2po2B:
undetectable		 6gbnB-2po2B:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 4 ASP B 151
ILE B  36
PRO B  35
LEU B  54
 None
 1.29A 6mkeB-2po2B:
undetectable		 6mkeB-2po2B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2po2 PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
(Pyrococcus
abyssi) 		4 / 4 ASP B 151
ILE B  36
PRO B  35
LEU B  54
 None
 1.34A 6mkeA-2po2B:
undetectable		 6mkeA-2po2B:
14.29