SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2po3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		4 / 8 ALA A1191
LEU A1217
LEU A1083
ALA A1087
 None
 0.80A 1e7cA-2po3A:
undetectable		 1e7cA-2po3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 12 GLY A1066
ALA A1065
SER A1187
GLY A1189
LEU A1188
 None
 1.15A 1igxA-2po3A:
undetectable		 1igxA-2po3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 11 LEU A1147
VAL A1358
TYR A1298
TYR A1329
PRO A1332
 None
None
None
T4K  A1500 ( 4.2A)
None
 1.01A 1klmA-2po3A:
1.8		 1klmA-2po3A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 8 ASP A1171
ALA A1173
GLY A1207
GLY A1208
ALA A1106
 T4K  A1500 ( 2.7A)
T4K  A1500 ( 3.4A)
None
None
None
 0.98A 1sguA-2po3A:
undetectable		 1sguA-2po3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 12 TYR A1273
LEU A1359
ILE A1367
ARG A1025
LEU A1277
 None
 1.19A 1tw4B-2po3A:
undetectable		 1tw4B-2po3A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		4 / 8 GLY A1024
GLY A1364
THR A1365
ALA A1366
 T4K  A1500 ( 3.3A)
None
None
None
 0.57A 2ej3A-2po3A:
undetectable		 2ej3A-2po3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 10 ILE A1372
VAL A1375
ALA A1376
VAL A1285
VAL A1301
 None
 0.91A 2nnjA-2po3A:
undetectable		 2nnjA-2po3A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_1
(NON-STRUCTURAL
PROTEIN 5)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		3 / 3 SER A1331
HIS A1350
ASP A1122
 None
 0.69A 2wa2B-2po3A:
undetectable		 2wa2B-2po3A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_1
(ADENOSYLHOMOCYSTEINA
SE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 12 THR A1103
THR A1351
LEU A1147
GLY A1144
PHE A1116
 T4K  A1500 ( 4.6A)
None
None
None
None
 1.37A 3g1uB-2po3A:
undetectable		 3g1uB-2po3A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		4 / 7 GLY A1149
GLY A1186
PHE A1100
PHE A1330
 None
None
T4K  A1500 ( 4.0A)
None
 0.92A 3ko0M-2po3A:
undetectable
3ko0P-2po3A:
undetectable		 3ko0M-2po3A:
12.29
3ko0P-2po3A:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 11 LEU A1047
SER A1245
LEU A1053
LEU A1042
LEU A1038
 None
 1.26A 3ndvA-2po3A:
undetectable
3ndvB-2po3A:
undetectable		 3ndvA-2po3A:
24.06
3ndvB-2po3A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 11 LEU A1042
LEU A1038
LEU A1047
SER A1245
LEU A1053
 None
 1.20A 3ndvA-2po3A:
undetectable
3ndvB-2po3A:
undetectable		 3ndvA-2po3A:
24.06
3ndvB-2po3A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 11 LEU A1047
SER A1245
LEU A1053
LEU A1042
LEU A1038
 None
 1.20A 3ndvC-2po3A:
undetectable
3ndvD-2po3A:
undetectable		 3ndvC-2po3A:
24.06
3ndvD-2po3A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 11 LEU A1042
LEU A1038
LEU A1047
SER A1245
LEU A1053
 None
 1.27A 3ndvC-2po3A:
undetectable
3ndvD-2po3A:
undetectable		 3ndvC-2po3A:
24.06
3ndvD-2po3A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 12 PHE A1196
GLY A1208
GLY A1252
ALA A1204
PHE A1205
 None
 1.13A 3sudB-2po3A:
undetectable		 3sudB-2po3A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		4 / 8 PHE A1330
ILE A1300
GLY A1149
ASN A1125
 None
 0.90A 4fgjA-2po3A:
undetectable
4fgjB-2po3A:
undetectable		 4fgjA-2po3A:
19.04
4fgjB-2po3A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 8 ALA A1209
VAL A1061
PHE A1196
GLY A1208
ALA A1076
 None
None
None
None
T4K  A1500 ( 3.1A)
 1.46A 4zjzA-2po3A:
3.8		 4zjzA-2po3A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 8 ALA A1209
VAL A1061
PHE A1196
GLY A1208
ALA A1076
 None
None
None
None
T4K  A1500 ( 3.1A)
 1.48A 4zjzB-2po3A:
4.8		 4zjzB-2po3A:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		4 / 5 ARG A1222
THR A1073
HIS A1225
ALA A1072
 None
 1.27A 5mfxA-2po3A:
undetectable		 5mfxA-2po3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 12 ILE A1094
MET A1095
ALA A1141
ALA A1086
ALA A1191
 None
 1.02A 5zw4A-2po3A:
3.4		 5zw4A-2po3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		5 / 6 ALA A1172
SER A1195
GLY A1208
THR A1073
ILE A1221
 None
T4K  A1500 ( 2.8A)
None
None
None
 1.20A 6f8cA-2po3A:
0.0		 6f8cA-2po3A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2po3 4-DEHYDRASE
(Streptomyces
venezuelae) 		3 / 3 ARG A1220
LEU A1231
PHE A1229
 None
 0.80A 6nknP-2po3A:
undetectable		 6nknP-2po3A:
19.09