SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2po4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 LEU A 899
ALA A 240
GLY A 233
ILE A 234
 None
 0.79A 1d4sB-2po4A:
undetectable		 1d4sB-2po4A:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 6 LEU A1075
ILE A 582
GLU A1081
ASP A1085
 None
 1.15A 1ditH-2po4A:
undetectable
1ditP-2po4A:
undetectable		 1ditH-2po4A:
12.35
1ditP-2po4A:
1.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 PHE A 529
LEU A 664
SER A 390
 None
 0.79A 1e7aA-2po4A:
2.1		 1e7aA-2po4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 TYR A  89
GLN A 161
THR A 165
GLN A 400
 None
 1.45A 1eiiA-2po4A:
undetectable		 1eiiA-2po4A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 10 ALA A 158
ARG A 104
LEU A 103
ALA A 100
ILE A 242
 None
 1.10A 1g5yC-2po4A:
undetectable		 1g5yC-2po4A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 9 VAL A 156
GLY A 159
ALA A 245
ILE A 242
SER A 249
 None
 1.32A 1gtnL-2po4A:
undetectable
1gtnM-2po4A:
undetectable		 1gtnL-2po4A:
5.73
1gtnM-2po4A:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 9 VAL A 556
GLY A 956
ALA A 462
ILE A 960
THR A 552
 None
 0.99A 1gtnL-2po4A:
undetectable
1gtnM-2po4A:
undetectable		 1gtnL-2po4A:
5.73
1gtnM-2po4A:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 ILE A1045
LEU A1050
LEU A 576
GLY A 575
ALA A1084
 None
 1.11A 1hvyD-2po4A:
undetectable		 1hvyD-2po4A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 ASP A 389
SER A 396
SER A 280
ASN A 285
 None
 1.23A 1ig3A-2po4A:
undetectable
1ig3B-2po4A:
undetectable		 1ig3A-2po4A:
12.79
1ig3B-2po4A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 LEU A 491
LEU A 487
SER A 484
ARG A 480
ALA A 462
 None
 0.97A 1n5xA-2po4A:
undetectable		 1n5xA-2po4A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 LEU A 491
LEU A 487
SER A 484
ARG A 480
ALA A 462
 None
 0.97A 1n5xB-2po4A:
1.7		 1n5xB-2po4A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 SER A 680
LEU A 816
VAL A 917
GLY A 919
ALA A 918
 None
 0.98A 1pxxC-2po4A:
1.2		 1pxxC-2po4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 GLY A 574
GLY A1042
ILE A 980
SER A 808
TYR A 811
 None
 1.20A 1ri4A-2po4A:
undetectable		 1ri4A-2po4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 GLY A 524
ASP A 525
ASN A 494
 None
 0.54A 1vq1A-2po4A:
undetectable		 1vq1A-2po4A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 6 ILE A 291
ALA A 294
THR A  72
ALA A  77
 None
 0.94A 1w0gA-2po4A:
undetectable		 1w0gA-2po4A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 PHE A 880
ARG A 318
ASN A 319
 None
 0.68A 1xzxX-2po4A:
undetectable		 1xzxX-2po4A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 LEU A 782
GLY A 687
LEU A 193
GLY A 192
TYR A 698
 None
 0.88A 1y4lA-2po4A:
undetectable		 1y4lA-2po4A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 6 ASN A 617
MET A 569
LEU A 611
ILE A 654
 None
 1.01A 1z95A-2po4A:
undetectable		 1z95A-2po4A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZP4_C_C2FC997_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 10 GLN A 856
GLN A 863
GLN A 836
PHE A 831
LEU A 854
 None
 1.50A 1zp4C-2po4A:
0.0		 1zp4C-2po4A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
209D_C_DVAC2_0
(N8-ACTINOMYCIN D)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 THR A 674
PRO A 672
THR A 676
 None
 0.72A 209dC-2po4A:
undetectable		 209dC-2po4A:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_C_H4BC1290_1
(PTERIDINE REDUCTASE
1)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 SER A 528
LEU A 554
LEU A 487
LEU A 491
 None
 0.96A 2bfpC-2po4A:
undetectable		 2bfpC-2po4A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 ILE A 234
LEU A  19
PHE A  34
LYS A  35
LEU A 220
 None
 0.94A 2d0kA-2po4A:
undetectable		 2d0kA-2po4A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 6 ALA A1011
TYR A 987
ILE A1025
ILE A 822
 None
 1.13A 2dcfA-2po4A:
undetectable		 2dcfA-2po4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 TYR A  33
ASN A  32
ARG A 128
GLU A 125
 None
 1.11A 2fl5E-2po4A:
undetectable
2fl5F-2po4A:
undetectable		 2fl5E-2po4A:
10.49
2fl5F-2po4A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 5 LEU A 999
ILE A1007
ILE A1025
ALA A1026
 None
 0.74A 2i2zA-2po4A:
1.7		 2i2zA-2po4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 11 TRP A 218
ASN A 148
PHE A  34
ILE A  12
ALA A  23
 None
 1.32A 2iyfA-2po4A:
undetectable		 2iyfA-2po4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 TRP A 218
ASN A 148
PHE A  34
ILE A  12
ALA A  23
 None
 1.29A 2iyfB-2po4A:
undetectable		 2iyfB-2po4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 LYS A 670
GLU A 658
ILE A 668
GLU A 191
 None
 0.95A 2j9dJ-2po4A:
0.3
2j9dK-2po4A:
0.0
2j9dL-2po4A:
undetectable		 2j9dJ-2po4A:
7.64
2j9dK-2po4A:
7.64
2j9dL-2po4A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 LYS A 670
GLU A 658
ILE A 668
GLU A 191
 None
 0.95A 2j9dJ-2po4A:
0.3
2j9dK-2po4A:
0.0
2j9dL-2po4A:
undetectable		 2j9dJ-2po4A:
7.64
2j9dK-2po4A:
7.64
2j9dL-2po4A:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O5Y_H_STRH249_1
(CHIMERIC ANTIBODY
FAB 1E9-DB3)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 ASN A 563
GLY A 564
THR A 924
SER A 974
 None
 1.25A 2o5yH-2po4A:
undetectable
2o5yL-2po4A:
undetectable		 2o5yH-2po4A:
11.87
2o5yL-2po4A:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 9 ALA A 819
ALA A 915
GLY A 916
GLY A 919
ILE A 882
 None
 0.98A 2v7bA-2po4A:
undetectable		 2v7bA-2po4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 9 ALA A 819
ALA A 915
GLY A 916
GLY A 919
ILE A 882
 None
 0.96A 2v7bB-2po4A:
undetectable		 2v7bB-2po4A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_A_FOLA401_0
(DIHYDROFOLATE
REDUCTASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 ALA A 294
LEU A  62
PHE A  81
ILE A 284
TYR A 217
 None
 1.12A 2w3bA-2po4A:
undetectable		 2w3bA-2po4A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 ALA A 294
LEU A  62
PHE A  81
ILE A 284
TYR A 217
 None
 1.15A 2w3bB-2po4A:
undetectable		 2w3bB-2po4A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3M_A_FOLA1188_0
(DIHYDROFOLATE
REDUCTASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		6 / 12 ALA A 294
LEU A  62
PHE A  81
ILE A 284
TYR A 217
THR A  72
 None
 1.43A 2w3mA-2po4A:
undetectable		 2w3mA-2po4A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 GLY A 589
TRP A 975
MET A 570
LEU A1087
VAL A 971
 None
 1.14A 2w8yA-2po4A:
undetectable		 2w8yA-2po4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 ALA A1011
TYR A 987
ILE A1025
ILE A 822
 None
 1.15A 2zm7A-2po4A:
undetectable		 2zm7A-2po4A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AMU_A_AG2A422_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 5 GLU A 537
ASN A 506
VAL A 543
ARG A 540
 None
 1.28A 3amuA-2po4A:
0.0		 3amuA-2po4A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA608_1
(CHITINASE A)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 6 ASN A 617
SER A 615
ALA A 614
ASP A 610
 None
 1.38A 3aruA-2po4A:
undetectable		 3aruA-2po4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 SER A 824
GLY A 916
GLY A 919
 None
 0.56A 3bogA-2po4A:
undetectable
3bogC-2po4A:
undetectable		 3bogA-2po4A:
undetectable
3bogC-2po4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 10 TYR A 217
THR A 167
SER A 168
ASN A 169
LEU A 210
 None
 1.20A 3casA-2po4A:
undetectable		 3casA-2po4A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 ASP A 198
GLN A 186
GLU A 191
GLU A 658
 None
 1.06A 3dh0A-2po4A:
undetectable		 3dh0A-2po4A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 10 LEU A 611
ALA A 568
ILE A 925
GLY A 928
THR A 562
 None
 1.16A 3el5A-2po4A:
undetectable		 3el5A-2po4A:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 10 ALA A 913
VAL A 890
ALA A 321
LEU A 859
PHE A 831
 None
 1.05A 3fl9A-2po4A:
undetectable		 3fl9A-2po4A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_F_TOPF200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 10 ALA A 913
VAL A 890
ALA A 321
LEU A 859
PHE A 831
 None
 1.09A 3fl9F-2po4A:
undetectable		 3fl9F-2po4A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 THR A 170
LYS A 670
GLU A 205
 None
 1.02A 3ijdB-2po4A:
undetectable		 3ijdB-2po4A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 GLU A 807
GLY A 575
VAL A1043
ILE A1039
ASN A1035
 None
 1.10A 3jb2A-2po4A:
undetectable		 3jb2A-2po4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 6 LEU A 394
SER A 396
ILE A 443
PHE A 304
 None
 0.98A 3ko0S-2po4A:
1.7		 3ko0S-2po4A:
5.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 ARG A 627
ASP A 741
GLN A 724
 None
 0.73A 3lcvB-2po4A:
undetectable		 3lcvB-2po4A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEG_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 ASN A  32
VAL A  20
TYR A 147
PHE A 145
LEU A 135
 None
 1.41A 3megA-2po4A:
0.4		 3megA-2po4A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 ILE A 582
GLN A1082
GLN A1083
LEU A 590
 None
 0.73A 3ozwA-2po4A:
undetectable		 3ozwA-2po4A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 ILE A 777
GLN A 781
ALA A 784
LEU A 785
 None
 0.69A 3ozwA-2po4A:
undetectable		 3ozwA-2po4A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 LEU A 571
ASN A 567
GLY A 589
ILE A1057
 None
 0.83A 3spkB-2po4A:
undetectable		 3spkB-2po4A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 LEU A 899
ALA A 240
GLY A 233
ILE A 234
 None
 0.76A 3spkB-2po4A:
undetectable		 3spkB-2po4A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 GLY A  50
ILE A 214
GLY A 219
SER A  46
ALA A 158
 None
 0.95A 3sueA-2po4A:
undetectable		 3sueA-2po4A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 GLY A  50
ILE A 214
GLY A 219
SER A  46
ALA A 158
 None
 0.98A 3sufB-2po4A:
undetectable		 3sufB-2po4A:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 SER A 209
VAL A 252
THR A 199
TYR A 431
 None
 0.89A 3tneB-2po4A:
undetectable		 3tneB-2po4A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 VAL A 693
PHE A 738
ILE A 777
ILE A 770
LEU A 739
 None
 1.02A 3w67D-2po4A:
undetectable		 3w67D-2po4A:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 ILE A  12
ASP A  13
GLN A 150
GLY A  50
 None
 0.79A 4ac9C-2po4A:
undetectable		 4ac9C-2po4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 ILE A  12
ASP A  13
GLN A 150
GLY A  50
 None
 0.78A 4acaC-2po4A:
undetectable		 4acaC-2po4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 ILE A  12
ASP A  13
GLN A 150
GLY A  50
 None
 0.69A 4acbC-2po4A:
undetectable		 4acbC-2po4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 9 ALA A 819
ALA A 915
GLY A 916
GLY A 919
ILE A 882
 None
 0.94A 4eatB-2po4A:
undetectable		 4eatB-2po4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 LEU A 816
ILE A 882
ASP A 929
ALA A 568
GLY A 926
 None
 1.12A 4hfpD-2po4A:
undetectable		 4hfpD-2po4A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 TRP A 975
GLN A 934
THR A 973
 None
 0.78A 4m2xA-2po4A:
undetectable		 4m2xA-2po4A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 LEU A  36
TYR A 230
ASN A 136
ARG A 128
 None
 0.99A 4m5mA-2po4A:
undetectable		 4m5mA-2po4A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M83_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 11 TRP A 218
ASN A 148
PHE A  34
ILE A  12
ALA A  23
 None
 1.33A 4m83A-2po4A:
undetectable		 4m83A-2po4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 8 ASN A 617
MET A 569
LEU A 611
ILE A 654
 None
 1.01A 4ok1A-2po4A:
undetectable		 4ok1A-2po4A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 ASN A 617
MET A 569
LEU A 611
ILE A 654
 None
 1.00A 4okwA-2po4A:
undetectable		 4okwA-2po4A:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 GLN A 469
LEU A 471
ASN A 954
ALA A 442
TYR A 350
 None
 1.15A 4pclA-2po4A:
undetectable		 4pclA-2po4A:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_ACTA202_0
(RETINOL-BINDING
PROTEIN 2)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 6 TYR A  89
GLU A 301
THR A 165
LEU A 164
 None
 1.36A 4qztA-2po4A:
undetectable		 4qztA-2po4A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 LEU A  55
LEU A  62
THR A 165
VAL A 295
ALA A 294
 None
 1.11A 4x1kD-2po4A:
undetectable		 4x1kD-2po4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 9 LEU A 490
LEU A 467
LEU A 471
LEU A 535
ALA A 534
 None
 1.13A 5dqfA-2po4A:
undetectable		 5dqfA-2po4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 VAL A 207
SER A 208
ALA A 211
GLY A 233
 None
 0.89A 5fpdB-2po4A:
undetectable		 5fpdB-2po4A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 SER A 680
LEU A 816
VAL A 917
GLY A 919
ALA A 918
 None
 1.03A 5iktA-2po4A:
0.7		 5iktA-2po4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 8 ALA A 522
LEU A 361
LEU A 535
MET A 502
LEU A 532
 None
 1.36A 5jqbA-2po4A:
undetectable
5jqbB-2po4A:
0.4		 5jqbA-2po4A:
14.77
5jqbB-2po4A:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		4 / 7 PRO A1066
PHE A 591
SER A 604
ASN A 600
 None
 1.21A 5l1fC-2po4A:
undetectable		 5l1fC-2po4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 ALA A 568
LEU A 571
PRO A 979
ILE A 920
LEU A1036
 None
 1.11A 5ljcA-2po4A:
undetectable		 5ljcA-2po4A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 VAL A 194
ASP A 198
GLU A 195
LEU A 188
THR A 674
 None
 1.12A 5m5cB-2po4A:
undetectable		 5m5cB-2po4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 10 VAL A 194
ASP A 198
GLU A 195
LEU A 188
THR A 674
 None
 1.13A 5m5cE-2po4A:
undetectable		 5m5cE-2po4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 GLN A  60
TYR A  89
ILE A 291
ALA A 290
VAL A  58
 None
 1.18A 5n0sB-2po4A:
undetectable		 5n0sB-2po4A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 12 LEU A 519
GLN A 348
ILE A 398
LEU A 394
ILE A 358
 None
 1.13A 5y2tB-2po4A:
undetectable		 5y2tB-2po4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EUQ_A_DXCA502_0
(MULTIDRUG
TRANSPORTER MDFA)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		5 / 11 LEU A 332
GLN A 878
GLY A 876
GLN A 316
MET A 419
 None
 1.42A 6euqA-2po4A:
0.4		 6euqA-2po4A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 LEU A 649
GLN A 724
LYS A 740
 None
 0.99A 6exiB-2po4A:
undetectable		 6exiB-2po4A:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2po4 VIRION RNA
POLYMERASE
(Escherichia
virus
N4) 		3 / 3 LEU A 649
GLN A 724
LYS A 740
 None
 0.96A 6exiA-2po4A:
undetectable		 6exiA-2po4A:
6.30