SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pod'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3001_1
(SERUM ALBUMIN)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		5 / 11 TRP A  48
ARG A  52
LEU A  53
ARG A  67
ALA A  65
 None
 1.37A 1hk1A-2podA:
0.4		 1hk1A-2podA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		4 / 4 SER A 221
ILE A 247
VAL A 266
THR A 240
 None
 0.96A 1u70A-2podA:
undetectable		 1u70A-2podA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		3 / 3 LEU A 328
LEU A 292
MET A 291
 None
None
NA  A 409 ( 4.6A)
 0.86A 2itzA-2podA:
undetectable		 2itzA-2podA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2MJI_A_KTRA201_1
(FATTY ACID-BINDING
PROTEIN, INTESTINAL)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		5 / 12 MET A 249
THR A 271
LEU A 272
PHE A 278
LEU A 281
 None
 1.29A 2mjiA-2podA:
0.0		 2mjiA-2podA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		3 / 3 GLU A 160
LEU A 163
ASP A 164
 None
 0.41A 3ko0A-2podA:
undetectable		 3ko0A-2podA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		3 / 3 GLU A 160
LEU A 163
ASP A 164
 None
 0.31A 3ko0T-2podA:
undetectable		 3ko0T-2podA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		5 / 12 GLY A 353
ILE A 370
ASN A 119
VAL A 347
SER A 346
 None
 1.10A 3nk7A-2podA:
undetectable		 3nk7A-2podA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		4 / 8 ASN A  16
PRO A  15
PHE A  35
TRP A 354
 None
 1.20A 4v2zC-2podA:
undetectable		 4v2zC-2podA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		4 / 6 SER A 301
GLU A 302
GLY A  30
GLY A  32
 None
 0.88A 5cdnA-2podA:
undetectable
5cdnB-2podA:
undetectable		 5cdnA-2podA:
21.69
5cdnB-2podA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		4 / 6 SER A 301
GLU A 302
GLY A  30
GLY A  32
 None
 0.92A 5cdnR-2podA:
undetectable
5cdnS-2podA:
undetectable		 5cdnR-2podA:
21.69
5cdnS-2podA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		5 / 10 GLY A 324
LEU A  17
TRP A  19
LEU A 358
LEU A 382
 None
 1.15A 5fhzC-2podA:
undetectable		 5fhzC-2podA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		4 / 8 HIS A 369
VAL A 365
THR A 171
ALA A 172
 None
 0.81A 5tt3H-2podA:
undetectable		 5tt3H-2podA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		3 / 3 ARG A 157
ARG A 348
ARG A 147
 None
 0.99A 6bplA-2podA:
undetectable
6bplB-2podA:
undetectable		 6bplA-2podA:
13.12
6bplB-2podA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 2pod MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME
(Burkholderia
pseudomallei) 		5 / 11 THR A 323
GLU A 345
SER A 331
ALA A 330
ALA A 273
 None
 1.42A 6efnA-2podA:
5.1		 6efnA-2podA:
21.85