SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2poe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		5 / 12 TYR A  53
LEU A 103
ILE A  67
ILE A 166
ILE A 168
 None
 1.28A 2efjA-2poeA:
undetectable		 2efjA-2poeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		4 / 8 ILE A  21
PHE A  44
GLY A  69
GLY A  70
 None
 0.76A 2qx4A-2poeA:
undetectable
2qx4B-2poeA:
undetectable		 2qx4A-2poeA:
22.92
2qx4B-2poeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		4 / 8 PHE A  30
ILE A  21
GLY A  69
GLY A  70
 None
 0.77A 2qx4A-2poeA:
undetectable
2qx4B-2poeA:
undetectable		 2qx4A-2poeA:
22.92
2qx4B-2poeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		4 / 6 ILE A  21
PHE A  44
GLY A  69
GLY A  70
 None
 0.77A 2qx6A-2poeA:
undetectable
2qx6B-2poeA:
undetectable		 2qx6A-2poeA:
22.92
2qx6B-2poeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		4 / 6 PHE A  30
ILE A  21
GLY A  69
GLY A  70
 None
 0.76A 2qx6A-2poeA:
undetectable
2qx6B-2poeA:
undetectable		 2qx6A-2poeA:
22.92
2qx6B-2poeA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		4 / 7 ILE A  21
LEU A  47
PHE A  44
PHE A 138
 None
 1.01A 2vctD-2poeA:
undetectable		 2vctD-2poeA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_B_NIOB5661_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		4 / 8 ILE A  91
ALA A 110
ASN A 115
THR A 116
 None
 0.80A 3hrdA-2poeA:
undetectable
3hrdB-2poeA:
undetectable		 3hrdA-2poeA:
16.35
3hrdB-2poeA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		5 / 11 ASP A  27
LEU A 151
PHE A  58
LEU A  28
ILE A  21
 None
 1.43A 3o94B-2poeA:
undetectable		 3o94B-2poeA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		4 / 5 LEU A  32
GLY A 139
PHE A 138
PHE A  44
 None
 1.20A 3smtA-2poeA:
undetectable		 3smtA-2poeA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		5 / 12 LEU A 103
PHE A  44
ILE A 123
GLY A  69
THR A  56
 None
 1.11A 4nkvC-2poeA:
undetectable		 4nkvC-2poeA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		5 / 12 LEU A 103
PHE A  44
ILE A 123
GLY A  69
THR A  56
 None
 1.10A 4nkvD-2poeA:
undetectable		 4nkvD-2poeA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		5 / 12 THR A 116
ASP A  88
ASP A  89
TYR A 135
GLY A 109
 None
FMT  A 202 (-4.8A)
None
FMT  A 203 ( 4.1A)
None
 1.50A 4qb9E-2poeA:
undetectable		 4qb9E-2poeA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_1_BEZ1801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		3 / 3 LEU A 103
PHE A  33
ILE A 102
 None
FMT  A 204 ( 4.4A)
FMT  A 201 (-4.9A)
 0.63A 5dzk1-2poeA:
undetectable
5dzkF-2poeA:
undetectable
5dzkM-2poeA:
undetectable		 5dzk1-2poeA:
0.54
5dzkF-2poeA:
21.96
5dzkM-2poeA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		3 / 3 LEU A 131
GLN A 130
LYS A 108
 None
None
FMT  A 203 ( 4.8A)
 0.92A 6exiB-2poeA:
undetectable		 6exiB-2poeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		3 / 3 LEU A 131
GLN A 130
LYS A 108
 None
None
FMT  A 203 ( 4.8A)
 0.93A 6exiA-2poeA:
undetectable		 6exiA-2poeA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 2poe CYCLOPHILIN-LIKE
PROTEIN, PUTATIVE
(Cryptosporidium
parvum) 		5 / 12 LEU A  28
ILE A 123
LEU A 131
GLY A 139
PHE A  30
 None
 1.36A 6qyaB-2poeA:
undetectable		 6qyaB-2poeA:
19.87