SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA304_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		4 / 4 GLN A  47
PRO A  60
VAL A  58
GLU A  57
 None
 1.44A 3huoA-2pofA:
undetectable		 3huoA-2pofA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		3 / 3 THR A  33
LYS A 114
GLU A  41
 None
 0.78A 3ijdB-2pofA:
undetectable		 3ijdB-2pofA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 12 GLY A 208
SER A 209
ALA A 237
ILE A  84
LEU A  92
 None
 1.03A 3mb5A-2pofA:
undetectable		 3mb5A-2pofA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 10 ILE A  37
ASP A  69
LEU A  77
HIS A 140
HIS A 142
 None
 0.47A 3o1cA-2pofA:
8.0		 3o1cA-2pofA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 10 ILE A  37
ASP A  69
LEU A  77
HIS A 140
HIS A 142
 None
 0.48A 3o1xA-2pofA:
7.9		 3o1xA-2pofA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 10 ILE A  37
ASP A  69
LEU A  77
HIS A 140
HIS A 142
 None
 0.47A 3qgzA-2pofA:
8.0		 3qgzA-2pofA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		4 / 4 PHE A 139
HIS A 138
GLY A  86
ILE A  84
 None
 1.49A 4k50E-2pofA:
0.0		 4k50E-2pofA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 12 ALA A 237
PHE A 193
GLY A  63
LEU A  78
PHE A 101
 None
 1.04A 5fsaA-2pofA:
undetectable		 5fsaA-2pofA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM9_B_ADNB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		5 / 12 ILE A  37
ASP A  69
LEU A  77
HIS A 140
HIS A 142
 None
 0.52A 5km9B-2pofA:
8.5		 5km9B-2pofA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 2pof CDP-DIACYLGLYCEROL
PYROPHOSPHATASE
(Escherichia
coli) 		7 / 12 ILE A  37
ASP A  69
ASN A  71
LEU A  77
THR A 135
HIS A 140
HIS A 142
 None
 0.95A 5uvmB-2pofA:
8.1		 5uvmB-2pofA:
19.47