SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 157
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 ( 3.8A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.34A 1a4lA-2pokA:
undetectable		 1a4lA-2pokA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 184
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.12A 1a4lA-2pokA:
undetectable		 1a4lA-2pokA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 157
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 ( 3.8A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.35A 1a4lB-2pokA:
undetectable		 1a4lB-2pokA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 184
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.14A 1a4lB-2pokA:
undetectable		 1a4lB-2pokA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 157
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 ( 3.8A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.31A 1a4lC-2pokA:
undetectable		 1a4lC-2pokA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 184
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.15A 1a4lC-2pokA:
undetectable		 1a4lC-2pokA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 157
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 ( 3.8A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.34A 1a4lD-2pokA:
undetectable		 1a4lD-2pokA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 184
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.10A 1a4lD-2pokA:
undetectable		 1a4lD-2pokA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 GLY A 422
ILE A 453
LEU A 145
VAL A 147
LEU A 180
 None
 1.17A 1r30A-2pokA:
undetectable		 1r30A-2pokA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 GLY A 422
ILE A 453
LEU A 145
VAL A 147
LEU A 180
 None
 1.17A 1r30B-2pokA:
undetectable		 1r30B-2pokA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A 109
GLY A 126
ASP A 124
ASP A 123
GLY A 424
 None
None
MN  A 460 ( 4.8A)
MN  A 460 (-2.6A)
None
 0.98A 1t3rA-2pokA:
undetectable		 1t3rA-2pokA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A 109
GLY A 126
ASP A 124
ASP A 123
GLY A 424
 None
None
MN  A 460 ( 4.8A)
MN  A 460 (-2.6A)
None
 0.98A 1t7iA-2pokA:
undetectable		 1t7iA-2pokA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.79A 1v7zA-2pokA:
4.2		 1v7zA-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.80A 1v7zB-2pokA:
4.2		 1v7zB-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.80A 1v7zC-2pokA:
4.2		 1v7zC-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.79A 1v7zD-2pokA:
4.1		 1v7zD-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.79A 1v7zE-2pokA:
4.1		 1v7zE-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.80A 1v7zF-2pokA:
4.2		 1v7zF-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		3 / 3 LEU A 296
PHE A 295
ARG A 334
 None
 0.82A 1xdkB-2pokA:
undetectable		 1xdkB-2pokA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		3 / 3 LEU A 296
PHE A 295
ARG A 334
 None
 0.82A 1xdkF-2pokA:
undetectable		 1xdkF-2pokA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_A_CTXA11_1
(CES1 PROTEIN)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 PRO A 303
LEU A 251
GLY A 250
LEU A 339
 None
 0.85A 1ya4A-2pokA:
2.3		 1ya4A-2pokA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 5 GLY A 424
GLN A 185
VAL A 121
SER A 428
 None
MN  A 460 (-3.4A)
None
None
 1.35A 1zzuA-2pokA:
undetectable		 1zzuA-2pokA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 5 LEU A  85
PRO A 146
VAL A 147
ILE A 149
 None
 0.75A 2aoiB-2pokA:
undetectable		 2aoiB-2pokA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 11 LEU A  85
ALA A 178
SER A  77
LEU A 145
VAL A 147
 None
 1.13A 2bxeB-2pokA:
undetectable		 2bxeB-2pokA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 HIS A 431
GLU A 184
HIS A  90
ASP A 123
ASP A 430
 None
MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
None
 1.13A 2pgrA-2pokA:
undetectable		 2pgrA-2pokA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		3 / 3 PRO A 341
GLY A 367
TYR A 364
 None
 0.67A 2vouA-2pokA:
1.9		 2vouA-2pokA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		3 / 3 PRO A 341
GLY A 367
TYR A 364
 None
 0.72A 2vouB-2pokA:
2.0		 2vouB-2pokA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		3 / 3 PRO A 341
GLY A 367
TYR A 364
 None
 0.72A 2vouC-2pokA:
2.3		 2vouC-2pokA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 5 ARG A 176
ALA A 413
ASP A 412
GLU A 415
 None
 1.22A 2xrzA-2pokA:
undetectable		 2xrzA-2pokA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 5 TYR A  88
ILE A 152
LEU A 414
LEU A 168
 None
 0.94A 2zb7A-2pokA:
undetectable		 2zb7A-2pokA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.80A 3a6jA-2pokA:
4.1		 3a6jA-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 7 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.79A 3a6jB-2pokA:
4.1		 3a6jB-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.80A 3a6jC-2pokA:
4.1		 3a6jC-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.80A 3a6jE-2pokA:
3.9		 3a6jE-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 GLU A 184
HIS A  90
ASP A 123
GLU A 158
 MN  A 460 (-2.3A)
MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
 0.80A 3a6jF-2pokA:
4.1		 3a6jF-2pokA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 GLY A 186
GLY A 424
ALA A 420
ASP A 124
GLU A 435
 None
None
None
MN  A 460 ( 4.8A)
None
 0.96A 3ckkA-2pokA:
undetectable		 3ckkA-2pokA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DGQ_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 5 ARG A  55
ILE A  52
TYR A  22
THR A 129
 None
 1.05A 3dgqA-2pokA:
undetectable		 3dgqA-2pokA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HRD_E_NIOE5660_1
(NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT
NICOTINATE
DEHYDROGENASE MEDIUM
MOLYBDOPTERIN
SUBUNIT)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		3 / 3 GLU A 157
GLU A 154
TRP A 183
 MN  A 460 ( 3.8A)
None
None
 0.91A 3hrdA-2pokA:
undetectable
3hrdE-2pokA:
undetectable
3hrdF-2pokA:
undetectable		 3hrdA-2pokA:
22.50
3hrdE-2pokA:
22.50
3hrdF-2pokA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		3 / 3 ASP A 243
ARG A 245
ALA A 241
 None
 0.76A 3mbgC-2pokA:
1.6		 3mbgC-2pokA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_B_017B200_1
(HIV-1 PROTEASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A 109
GLY A 126
ASP A 124
ASP A 123
GLY A 424
 None
None
MN  A 460 ( 4.8A)
MN  A 460 (-2.6A)
None
 1.04A 3oxwA-2pokA:
undetectable		 3oxwA-2pokA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A 109
GLY A 126
ASP A 124
ASP A 123
GLY A 424
 None
None
MN  A 460 ( 4.8A)
MN  A 460 (-2.6A)
None
 0.99A 3oy4B-2pokA:
undetectable		 3oy4B-2pokA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 9 ALA A 178
ASP A 179
VAL A 147
ILE A 152
ILE A  86
 None
BGC  A 458 (-2.4A)
None
None
None
 0.99A 3s43A-2pokA:
undetectable		 3s43A-2pokA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 GLY A 177
ALA A 178
VAL A 147
ILE A 152
ILE A  86
 None
 0.80A 3s54A-2pokA:
undetectable		 3s54A-2pokA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_2
(PROTEASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		6 / 12 GLY A 177
ALA A 178
ASP A 179
VAL A 147
ILE A 152
ILE A  86
 None
None
BGC  A 458 (-2.4A)
None
None
None
 1.42A 3s54B-2pokA:
undetectable		 3s54B-2pokA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A 232
THR A 205
ILE A 203
LEU A 305
ILE A 348
 None
 1.22A 3sp9A-2pokA:
undetectable		 3sp9A-2pokA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 7 VAL A  25
VAL A  56
PHE A  53
ILE A 128
 None
 0.95A 3zjqA-2pokA:
undetectable		 3zjqA-2pokA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 7 VAL A  25
VAL A  56
PHE A  53
ILE A 128
 None
 0.94A 3zjqB-2pokA:
undetectable		 3zjqB-2pokA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 7 LEU A 339
LYS A 347
VAL A 248
TYR A 252
 None
 1.03A 4b3qA-2pokA:
3.9		 4b3qA-2pokA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 9 LEU A 109
GLY A 126
ASP A 124
ASP A 123
GLY A 424
 None
None
MN  A 460 ( 4.8A)
MN  A 460 (-2.6A)
None
 1.03A 4dqcB-2pokA:
undetectable		 4dqcB-2pokA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 7 ASP A 123
GLU A 158
HIS A 431
GLU A 157
 MN  A 460 (-2.6A)
MN  A 460 ( 4.9A)
None
MN  A 460 ( 3.8A)
 0.98A 4hvrA-2pokA:
undetectable		 4hvrA-2pokA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A  29
GLY A 120
LEU A 423
THR A 129
ILE A 128
 None
 1.15A 4hytA-2pokA:
undetectable		 4hytA-2pokA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 12 LEU A  29
GLY A 120
LEU A 423
THR A 129
ILE A 128
 None
 1.17A 4hytC-2pokA:
undetectable		 4hytC-2pokA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A 109
GLY A 126
ASP A 124
ASP A 123
GLY A 424
 None
None
MN  A 460 ( 4.8A)
MN  A 460 (-2.6A)
None
 0.97A 4njtB-2pokA:
undetectable		 4njtB-2pokA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		7 / 11 HIS A  90
ASP A 123
GLU A 157
GLU A 158
GLU A 184
GLY A 403
HIS A 431
 MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 3.8A)
MN  A 460 ( 4.9A)
MN  A 460 (-2.3A)
None
None
 0.80A 4pqaA-2pokA:
33.7		 4pqaA-2pokA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		7 / 11 HIS A  90
ASP A 123
GLU A 157
GLU A 158
GLU A 184
GLY A 403
HIS A 431
 MN  A 460 (-3.7A)
MN  A 460 (-2.6A)
MN  A 460 ( 3.8A)
MN  A 460 ( 4.9A)
MN  A 460 (-2.3A)
None
None
 0.81A 4pqaA-2pokA:
33.7		 4pqaA-2pokA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 9 LEU A 109
GLY A 126
ASP A 124
ASP A 123
GLY A 424
 None
None
MN  A 460 ( 4.8A)
MN  A 460 (-2.6A)
None
 0.98A 4q1wA-2pokA:
undetectable		 4q1wA-2pokA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 PHE A  70
ALA A 172
LEU A 168
PHE A 421
 None
 0.94A 4rkuA-2pokA:
undetectable
4rkuJ-2pokA:
undetectable		 4rkuA-2pokA:
21.11
4rkuJ-2pokA:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 6 ARG A 131
ILE A 446
ILE A 128
ASP A 124
 None
None
None
MN  A 460 ( 4.8A)
 1.13A 4w5qA-2pokA:
undetectable		 4w5qA-2pokA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 6 ARG A 131
ILE A 446
ILE A 128
ASP A 124
 None
None
None
MN  A 460 ( 4.8A)
 1.20A 4w5tA-2pokA:
undetectable		 4w5tA-2pokA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 6 ARG A 131
ILE A 446
ILE A 128
ASP A 124
 None
None
None
MN  A 460 ( 4.8A)
 1.13A 4z4dA-2pokA:
undetectable		 4z4dA-2pokA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PRO A 341
VAL A 344
ILE A 348
VAL A 333
 None
 0.44A 5bmvC-2pokA:
undetectable		 5bmvC-2pokA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 6 PRO A 406
GLU A  61
ALA A  46
TYR A  66
 None
 1.07A 5igiA-2pokA:
undetectable		 5igiA-2pokA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 6 PRO A 406
GLU A  61
LEU A  42
TYR A  66
 None
 0.99A 5igiA-2pokA:
undetectable		 5igiA-2pokA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQB_B_IBPB706_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 8 ALA A 329
LEU A 239
LEU A 305
LEU A 362
LEU A 352
 None
 1.20A 5jqbA-2pokA:
0.1
5jqbB-2pokA:
undetectable		 5jqbA-2pokA:
20.56
5jqbB-2pokA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVN_B_PFLB410_1
(PROTON-GATED ION
CHANNEL)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		5 / 9 TYR A  91
ILE A 128
VAL A  71
TYR A  48
ILE A  52
 None
 1.11A 5mvnB-2pokA:
0.0		 5mvnB-2pokA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 7 VAL A  45
VAL A  71
PRO A  69
GLY A 155
 None
 0.85A 5x80C-2pokA:
undetectable
5x80D-2pokA:
undetectable		 5x80C-2pokA:
20.40
5x80D-2pokA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 6 PRO A 406
GLY A 405
ASN A 200
LYS A 201
 None
 1.03A 5xxiA-2pokA:
undetectable		 5xxiA-2pokA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		3 / 3 GLU A 257
ASP A 302
PRO A 303
 None
 0.77A 6berA-2pokA:
undetectable		 6berA-2pokA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 6 ARG A 131
ILE A 446
ILE A 128
ASP A 124
 None
None
None
MN  A 460 ( 4.8A)
 1.17A 6cbdA-2pokA:
undetectable		 6cbdA-2pokA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 2pok PEPTIDASE,
M20/M25/M40 FAMILY
(Streptococcus
pneumoniae) 		4 / 8 ASP A 374
SER A 373
SER A 455
VAL A 383
 BGC  A 459 (-3.6A)
BGC  A 459 (-4.9A)
BGC  A 458 (-3.7A)
None
 0.72A 6giqL-2pokA:
undetectable
6giqP-2pokA:
undetectable
6giqT-2pokA:
undetectable		 6giqL-2pokA:
24.41
6giqP-2pokA:
17.93
6giqT-2pokA:
9.56