SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 11 LEU A 361
LEU A 178
ALA A 171
LEU A 173
VAL A  67
 None
 1.13A 1ictA-2popA:
undetectable
1ictC-2popA:
undetectable		 1ictA-2popA:
17.56
1ictC-2popA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A 300
ALA A 299
PHE A 351
GLY A 301
 None
 1.32A 1mj2B-2popA:
undetectable		 1mj2B-2popA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_1
(METHIONINE REPRESSOR)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A 300
ALA A 299
PHE A 351
GLY A 301
 None
 1.32A 1mjoB-2popA:
undetectable		 1mjoB-2popA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A 300
ALA A 299
PHE A 351
GLY A 301
 None
 1.34A 1mjoA-2popA:
undetectable		 1mjoA-2popA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 4 HIS A 300
ALA A 299
PHE A 351
GLY A 301
 None
 1.31A 1mjoD-2popA:
undetectable		 1mjoD-2popA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 174
LEU A  64
ALA A  81
VAL A 172
LEU A 106
 None
 1.34A 1rbpA-2popA:
undetectable		 1rbpA-2popA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_C_DESC129_1
(TRANSTHYRETIN)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A 192
LEU A 190
LEU A 285
SER A  27
 None
 0.87A 1tz8C-2popA:
undetectable
1tz8D-2popA:
undetectable		 1tz8C-2popA:
17.56
1tz8D-2popA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 5 HIS A  47
SER A  46
GLU A  45
ASP A  40
 None
 1.44A 3tm4A-2popA:
undetectable		 3tm4A-2popA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 185
ASN A 186
GLU A 290
 None
 0.79A 3v4tA-2popA:
undetectable
3v4tC-2popA:
undetectable		 3v4tA-2popA:
23.89
3v4tC-2popA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLY A 274
ARG A 104
ILE A 272
LEU A 178
 None
 1.00A 4acbC-2popA:
undetectable		 4acbC-2popA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.85A 4d33A-2popA:
undetectable		 4d33A-2popA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.80A 4d33B-2popA:
undetectable		 4d33B-2popA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.77A 4d39A-2popA:
undetectable		 4d39A-2popA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 7 ARG A 187
ASN A 306
GLU A 308
ILE A 309
 None
 0.77A 4d39B-2popA:
undetectable		 4d39B-2popA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_B_SUZB201_1
(TRANSTHYRETIN)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A  27
LYS A 192
LEU A 190
LEU A 285
 None
 0.85A 4ikjA-2popA:
undetectable
4ikjB-2popA:
undetectable		 4ikjA-2popA:
17.56
4ikjB-2popA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 CYH A 235
ILE A 233
GLN A 237
ILE A 266
 None
 1.21A 4w5tA-2popA:
undetectable		 4w5tA-2popA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 SER A 322
LEU A 323
ASP A 324
LEU A 369
 None
 0.94A 4wozA-2popA:
undetectable
4wozB-2popA:
undetectable		 4wozA-2popA:
21.89
4wozB-2popA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP3_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ALA A 188
GLN A 202
LEU A 287
MET A 288
 None
 1.26A 4xp3A-2popA:
undetectable		 4xp3A-2popA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 CYH A 235
ILE A 233
GLN A 237
ILE A 266
 None
 1.18A 4z4cA-2popA:
undetectable		 4z4cA-2popA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1
(Homo
sapiens) 		4 / 6 CYH A 235
ILE A 233
GLN A 237
ILE A 266
 None
 1.16A 6cbdA-2popA:
undetectable		 6cbdA-2popA:
18.84