SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2poz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  45
ILE A  10
ALA A  37
GLY A  38
ALA A  91
 None
 0.86A 1bx4A-2pozA:
undetectable		 1bx4A-2pozA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 6 THR A 283
PHE A 265
GLU A 257
GLY A 256
 None
 1.16A 1icuC-2pozA:
undetectable
1icuD-2pozA:
undetectable		 1icuC-2pozA:
21.17
1icuD-2pozA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI3_A_PE2A1_1
(THYMIDINE KINASE)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 12 HIS A 307
GLU A 232
TYR A 334
TYR A  41
GLU A 332
 None
 1.42A 1ki3A-2pozA:
0.0		 1ki3A-2pozA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_A_BEZA524_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 6 THR A 283
PHE A 265
GLU A 257
GLY A 256
 None
 1.17A 1kqbA-2pozA:
undetectable
1kqbB-2pozA:
undetectable		 1kqbA-2pozA:
21.23
1kqbB-2pozA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 5 ILE A 325
ARG A 121
LEU A 321
PRO A 306
 None
 1.50A 1s8fA-2pozA:
2.7
1s8fB-2pozA:
undetectable		 1s8fA-2pozA:
21.07
1s8fB-2pozA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 11 VAL A 344
GLU A  36
GLU A 345
LEU A 370
ILE A 375
 None
 1.24A 1t6zA-2pozA:
undetectable		 1t6zA-2pozA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 10 ILE A  96
ALA A  95
ASN A   9
ALA A  37
ILE A  61
 None
 1.18A 2aclC-2pozA:
undetectable		 2aclC-2pozA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 7 MET A 288
LEU A 115
PHE A 116
GLY A 117
 None
 0.89A 2bdmA-2pozA:
undetectable		 2bdmA-2pozA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 12 ALA A 241
ARG A 175
ILE A 253
SER A 246
ASP A 235
 None
 1.20A 2ejtA-2pozA:
2.0		 2ejtA-2pozA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 11 SER A  56
ILE A  52
ALA A  95
ARG A  67
LEU A 100
 None
 1.34A 2v0mA-2pozA:
undetectable		 2v0mA-2pozA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 12 ILE A 314
LEU A 313
LEU A 347
THR A 290
THR A 318
 None
 1.06A 3dcjA-2pozA:
undetectable
3dcjB-2pozA:
undetectable		 3dcjA-2pozA:
19.02
3dcjB-2pozA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 7 GLY A 130
GLY A 133
GLU A 332
ALA A 336
 None
 0.87A 3fpjB-2pozA:
undetectable		 3fpjB-2pozA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 12 LEU A  55
ILE A  88
GLY A  92
ALA A  91
SER A  94
 None
 1.00A 3n8zB-2pozA:
undetectable		 3n8zB-2pozA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		6 / 12 GLN A  98
GLY A  35
ILE A  88
GLY A  38
ALA A  49
ALA A  47
 None
 1.38A 3sudC-2pozA:
undetectable		 3sudC-2pozA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 12 LEU A 156
VAL A 145
PRO A 148
ARG A 147
PHE A 337
 None
 1.35A 4q15B-2pozA:
undetectable		 4q15B-2pozA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		3 / 3 LYS A 157
ARG A 303
VAL A 304
 None
 0.75A 4x3uA-2pozA:
undetectable
4x3uB-2pozA:
undetectable		 4x3uA-2pozA:
10.24
4x3uB-2pozA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 4 LEU A  12
ILE A  39
HIS A  19
VAL A  21
 None
 1.25A 4xyzA-2pozA:
undetectable		 4xyzA-2pozA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 7 LEU A  55
GLY A  92
ALA A  91
SER A  94
 None
 0.86A 5f1aB-2pozA:
0.4		 5f1aB-2pozA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		3 / 3 VAL A 308
GLU A 232
GLU A 231
 None
 0.93A 5jsdB-2pozA:
undetectable
5jsdC-2pozA:
undetectable		 5jsdB-2pozA:
19.11
5jsdC-2pozA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 8 THR A 261
SER A  94
ALA A  82
SER A  79
 None
 0.85A 5l5fY-2pozA:
undetectable
5l5fZ-2pozA:
undetectable		 5l5fY-2pozA:
20.22
5l5fZ-2pozA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 8 GLN A 278
VAL A 204
ASP A 205
TYR A 159
 None
 1.03A 5vlmA-2pozA:
undetectable		 5vlmA-2pozA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 6 GLN A 320
ASN A 324
VAL A 112
LEU A 108
 None
 1.26A 5xdhA-2pozA:
undetectable
5xdhC-2pozA:
undetectable		 5xdhA-2pozA:
11.32
5xdhC-2pozA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 12 GLY A  35
ILE A  88
GLY A  38
ALA A  49
ALA A  47
 None
 1.03A 6c2mD-2pozA:
undetectable		 6c2mD-2pozA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 8 LEU A  55
VAL A   8
LEU A  60
ILE A  25
 None
 0.91A 6cb4A-2pozA:
undetectable		 6cb4A-2pozA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CHG_C_SAMC1101_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-4 SPECIFIC)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		5 / 12 ILE A 371
SER A  15
ASN A 374
LEU A 347
LEU A  22
 None
 1.19A 6chgC-2pozA:
undetectable		 6chgC-2pozA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 5 LEU A 161
TYR A 159
ILE A 330
GLY A 208
 None
 1.06A 6hd6A-2pozA:
undetectable		 6hd6A-2pozA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2poz PUTATIVE DEHYDRATASE
(Mesorhizobium
japonicum) 		4 / 5 ARG A  58
MET A  75
THR A  74
LEU A  71
 None
 1.33A 6nknJ-2pozA:
undetectable		 6nknJ-2pozA:
11.68