SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pp3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 10 ALA A  61
LEU A 356
SER A 381
PHE A  78
ILE A  63
 None
 1.11A 1g5yC-2pp3A:
undetectable		 1g5yC-2pp3A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 HIS A 173
THR A 167
GLY A 169
VAL A 179
TYR A 165
 None
LGT  A 501 (-3.8A)
None
None
None
 1.28A 1n2xA-2pp3A:
undetectable		 1n2xA-2pp3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 GLY A  77
ILE A 135
ALA A  93
ILE A  62
SER A  79
 None
 1.07A 1ve3B-2pp3A:
undetectable		 1ve3B-2pp3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 GLY A 169
GLY A 170
VAL A 213
LEU A 196
LEU A 217
 None
 0.98A 1ya4B-2pp3A:
undetectable		 1ya4B-2pp3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 GLY A 169
GLY A 170
VAL A 213
LEU A 196
LEU A 217
 None
 0.97A 1ya4C-2pp3A:
undetectable		 1ya4C-2pp3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H77_A_T3A1_1
(THRA PROTEIN)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ILE A  96
ALA A 131
ALA A  65
LEU A  33
ILE A  67
 None
 1.09A 2h77A-2pp3A:
undetectable		 2h77A-2pp3A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		4 / 5 PRO A 300
PRO A 303
ILE A 137
GLY A 307
 None
 1.12A 2jkjD-2pp3A:
undetectable		 2jkjD-2pp3A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		4 / 5 PRO A 300
PRO A 303
ILE A 137
GLY A 307
 None
 1.12A 2jkjF-2pp3A:
undetectable		 2jkjF-2pp3A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 GLN A 265
ALA A 268
ASP A 259
GLY A 292
LEU A 291
 None
 1.25A 2nv4A-2pp3A:
undetectable		 2nv4A-2pp3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 GLN A 265
ALA A 268
ASP A 259
GLY A 292
LEU A 291
 None
 1.28A 2nv4B-2pp3A:
undetectable		 2nv4B-2pp3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		4 / 8 LEU A 266
ARG A 238
VAL A 198
GLY A 199
 None
 0.67A 2qd5B-2pp3A:
undetectable		 2qd5B-2pp3A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_2
(PROTEASE RETROPEPSIN)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		6 / 12 LEU A  33
GLY A  77
ILE A  89
GLY A 306
ALA A  93
ILE A  63
 None
 1.39A 2rkfB-2pp3A:
undetectable		 2rkfB-2pp3A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 10 ARG A 214
ALA A 216
LEU A 176
LEU A 180
VAL A 183
 None
 1.04A 3o02A-2pp3A:
undetectable
3o02B-2pp3A:
undetectable		 3o02A-2pp3A:
23.54
3o02B-2pp3A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		3 / 3 TYR A 341
ARG A 159
HIS A 158
 None
 1.10A 4fubA-2pp3A:
undetectable		 4fubA-2pp3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ILE A  96
ALA A 131
ALA A  65
LEU A  33
ILE A  67
 None
 1.11A 4lnwA-2pp3A:
undetectable		 4lnwA-2pp3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ILE A  96
ALA A 131
ALA A  65
LEU A  33
ILE A  67
 None
 1.12A 4lnxA-2pp3A:
undetectable		 4lnxA-2pp3A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		4 / 8 LEU A 154
LEU A 155
ASP A 109
ILE A 108
 None
 0.91A 4lzrA-2pp3A:
undetectable		 4lzrA-2pp3A:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		3 / 3 ASP A 301
LEU A  57
ARG A  83
 None
LGT  A 501 ( 4.5A)
LGT  A 501 (-3.3A)
 0.90A 5e8qA-2pp3A:
undetectable		 5e8qA-2pp3A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 10 ILE A 194
GLY A 170
LEU A 196
LEU A 180
LEU A 176
 None
 1.33A 5fhzC-2pp3A:
undetectable		 5fhzC-2pp3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ALA A 212
LEU A 223
ILE A 194
VAL A 179
ASP A 226
 None
None
None
None
MG  A 901 ( 2.7A)
 1.32A 5vlmG-2pp3A:
undetectable		 5vlmG-2pp3A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 12 ILE A 135
ALA A 131
ALA A  93
ALA A 128
ILE A  28
 None
 1.15A 6a5zD-2pp3A:
undetectable		 6a5zD-2pp3A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		4 / 8 GLY A 307
ILE A 308
ASP A 301
PRO A 327
 None
 0.95A 6ag0A-2pp3A:
7.1		 6ag0A-2pp3A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		3 / 3 LEU A 291
GLN A 288
LYS A 320
 None
 0.98A 6exiB-2pp3A:
undetectable		 6exiB-2pp3A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		3 / 3 LEU A 291
GLN A 288
LYS A 320
 None
 0.99A 6exiA-2pp3A:
undetectable		 6exiA-2pp3A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		3 / 3 TRP A 369
ILE A 370
ASP A 160
 None
 0.88A 6i0y7-2pp3A:
undetectable		 6i0y7-2pp3A:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 2pp3 L-TALARATE/GALACTARA
TE DEHYDRATASE
(Salmonella
enterica) 		5 / 10 ILE A 274
LEU A 289
ASP A 259
LEU A 255
GLY A 262
 None
 1.42A 6r2eC-2pp3A:
undetectable		 6r2eC-2pp3A:
21.80