SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ppg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 7 ALA A 125
LEU A 123
THR A  69
VAL A  53
 None
 0.84A 1dvxB-2ppgA:
undetectable		 1dvxB-2ppgA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 120
ASP A 121
ASP A 103
HIS A 102
GLY A 292
 None
 1.49A 1ia0B-2ppgA:
0.0		 1ia0B-2ppgA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 7 PHE A  11
GLU A   9
VAL A  64
TRP A  66
 None
 1.37A 1jqdA-2ppgA:
0.0		 1jqdA-2ppgA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 ILE A 323
ALA A 326
VAL A 376
LEU A 386
ALA A 382
 None
 1.05A 1n4hA-2ppgA:
undetectable		 1n4hA-2ppgA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 PRO A 378
ILE A 319
GLY A 320
GLY A 322
THR A 318
 None
 1.13A 1nv8A-2ppgA:
undetectable		 1nv8A-2ppgA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 8 LEU A 329
VAL A 376
GLY A 375
LEU A 325
 None
 0.98A 1s1xA-2ppgA:
undetectable		 1s1xA-2ppgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 10 LEU A  85
ALA A 122
GLY A 117
GLY A 116
ILE A  81
 None
 0.89A 1sdvA-2ppgA:
undetectable		 1sdvA-2ppgA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A 120
ASP A 121
ASP A 103
HIS A 102
GLY A 292
 None
 1.49A 1tubB-2ppgA:
undetectable		 1tubB-2ppgA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 11 ALA A 122
LEU A 105
ALA A  87
LEU A  85
THR A  90
 None
 1.19A 1tz8A-2ppgA:
undetectable
1tz8B-2ppgA:
undetectable		 1tz8A-2ppgA:
15.40
1tz8B-2ppgA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 135
GLY A 375
GLY A 371
LEU A 355
GLU A 377
 None
 0.86A 2oxtB-2ppgA:
undetectable		 2oxtB-2ppgA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 7 ILE A  82
PRO A 378
GLY A  65
TRP A  66
 None
 1.02A 2pnjB-2ppgA:
2.7		 2pnjB-2ppgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		3 / 3 LEU A 161
PRO A 162
LEU A 172
 None
 0.49A 2po5B-2ppgA:
2.5		 2po5B-2ppgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		3 / 3 LEU A 161
PRO A 162
LEU A 172
 None
 0.40A 2po7B-2ppgA:
2.1		 2po7B-2ppgA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		3 / 3 LEU A 161
PRO A 162
LEU A 172
 None
 0.47A 2qd5B-2ppgA:
undetectable		 2qd5B-2ppgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 VAL A  55
ILE A  81
LEU A 123
ILE A   8
THR A  69
 None
 1.07A 2w3vA-2ppgA:
undetectable		 2w3vA-2ppgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 9 VAL A 376
GLY A 375
GLY A 373
ILE A 296
ALA A 326
 None
 0.91A 2z0yA-2ppgA:
2.5		 2z0yA-2ppgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 9 VAL A 376
GLY A 375
GLY A 373
ILE A 296
ALA A 326
 None
 0.82A 2z0yB-2ppgA:
undetectable		 2z0yB-2ppgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 7 ALA A 125
LEU A 123
THR A  69
VAL A  53
 None
 0.97A 3d2tA-2ppgA:
undetectable		 3d2tA-2ppgA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 6 ALA A 125
LEU A 123
THR A  69
VAL A  53
 None
 0.91A 3d2tB-2ppgA:
undetectable		 3d2tB-2ppgA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		3 / 3 LEU A 161
PRO A 162
LEU A 172
 None
 0.53A 3hcrA-2ppgA:
2.5		 3hcrA-2ppgA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 7 GLY A 180
PHE A 181
PHE A 348
PHE A 343
 None
 1.07A 3ko0D-2ppgA:
undetectable
3ko0E-2ppgA:
undetectable		 3ko0D-2ppgA:
12.56
3ko0E-2ppgA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 8 PHE A 348
PHE A 343
GLY A 180
PHE A 181
 None
 0.81A 3ko0O-2ppgA:
undetectable
3ko0Q-2ppgA:
undetectable		 3ko0O-2ppgA:
12.56
3ko0Q-2ppgA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 5 GLU A 163
LEU A 161
HIS A 345
GLY A 160
 None
 1.06A 3pp1A-2ppgA:
undetectable		 3pp1A-2ppgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCJ_B_AZMB229_1
(CARBONIC ANHYDRASE)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		3 / 3 GLN A 288
PHE A 239
TYR A 157
 None
 1.00A 3ucjA-2ppgA:
undetectable		 3ucjA-2ppgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 7 PRO A 289
SER A 332
HIS A 341
SER A 328
 None
 1.12A 4k7gB-2ppgA:
undetectable		 4k7gB-2ppgA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 145
LEU A 146
ALA A 333
MET A 291
LEU A 374
 None
 1.00A 4ltwA-2ppgA:
undetectable		 4ltwA-2ppgA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB304_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 4 GLY A  71
SER A  52
ARG A  51
PRO A  75
 None
 1.14A 4m93B-2ppgA:
0.0
4m93C-2ppgA:
0.0		 4m93B-2ppgA:
20.00
4m93C-2ppgA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 8 ILE A 128
VAL A 368
LEU A 329
ILE A 154
 None
 0.71A 4r38A-2ppgA:
undetectable		 4r38A-2ppgA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 328
ALA A 327
HIS A 341
MET A 359
 None
 1.45A 5dzkc-2ppgA:
1.6
5dzkq-2ppgA:
undetectable		 5dzkc-2ppgA:
19.85
5dzkq-2ppgA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 5 SER A 328
ALA A 327
HIS A 341
MET A 359
 None
 1.44A 5dzkf-2ppgA:
undetectable
5dzkt-2ppgA:
undetectable		 5dzkf-2ppgA:
19.85
5dzkt-2ppgA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 8 LEU A 374
LEU A 145
GLN A 298
MET A 291
 None
 1.18A 5hbsA-2ppgA:
undetectable		 5hbsA-2ppgA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		5 / 12 LEU A 374
SER A  52
GLU A 290
GLY A 292
GLY A 295
 None
 1.16A 5l6eA-2ppgA:
undetectable		 5l6eA-2ppgA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 2ppg PUTATIVE ISOMERASE
(Sinorhizobium
meliloti) 		4 / 4 VAL A 376
GLY A 357
ASP A 358
ASP A 360
 None
 0.87A 6cjkC-2ppgA:
undetectable		 6cjkC-2ppgA:
18.73