SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ppl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 GLN A  84
ASN A 119
LEU A  70
LEU A 154
 None
 1.17A 1hk2A-2pplA:
undetectable		 1hk2A-2pplA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 1.08A 1pxxA-2pplA:
undetectable		 1pxxA-2pplA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 9 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 1.07A 1pxxB-2pplA:
undetectable		 1pxxB-2pplA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 1.07A 1pxxC-2pplA:
undetectable		 1pxxC-2pplA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 1.07A 1pxxD-2pplA:
undetectable		 1pxxD-2pplA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A 169
GLY A 192
VAL A 105
ILE A  97
PHE A 200
 None
 0.98A 1zq9B-2pplA:
undetectable		 1zq9B-2pplA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 ALA A 174
GLY A 234
SER A 284
 None
NA  A 480 (-4.3A)
None
 0.55A 2ivuA-2pplA:
undetectable		 2ivuA-2pplA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
LEU A 172
GLY A  95
TRP A 104
VAL A 105
 None
 1.39A 2w8yA-2pplA:
undetectable		 2w8yA-2pplA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A 202
ARG A 208
GLN A 237
 None
 0.91A 2xnrA-2pplA:
undetectable		 2xnrA-2pplA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 10 ALA A 180
VAL A 143
GLY A 169
ILE A 168
VAL A 147
 None
 0.99A 3t3cB-2pplA:
undetectable		 3t3cB-2pplA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 360
GLY A 359
TYR A 402
ASP A 312
 None
 1.23A 3w9tA-2pplA:
undetectable		 3w9tA-2pplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 360
GLY A 359
TYR A 402
ASP A 312
 None
 1.22A 3w9tB-2pplA:
undetectable		 3w9tB-2pplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 360
GLY A 359
TYR A 402
ASP A 312
 None
 1.22A 3w9tC-2pplA:
undetectable		 3w9tC-2pplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 360
GLY A 359
TYR A 402
ASP A 312
 None
 1.23A 3w9tD-2pplA:
undetectable		 3w9tD-2pplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 360
GLY A 359
TYR A 402
ASP A 312
 None
 1.23A 3w9tE-2pplA:
undetectable		 3w9tE-2pplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 360
GLY A 359
TYR A 402
ASP A 312
 None
 1.23A 3w9tF-2pplA:
undetectable		 3w9tF-2pplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 VAL A 360
GLY A 359
TYR A 402
ASP A 312
 None
 1.22A 3w9tG-2pplA:
undetectable		 3w9tG-2pplA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 HIS A 170
LEU A 266
LEU A 231
ASP A 265
 None
 1.23A 4aqlA-2pplA:
undetectable		 4aqlA-2pplA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASP A 243
HIS A 175
ASP A 194
HIS A 221
GLY A 234
 None
None
None
None
NA  A 480 (-4.3A)
 1.45A 4bz6A-2pplA:
undetectable
4bz6B-2pplA:
undetectable		 4bz6A-2pplA:
23.93
4bz6B-2pplA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_A_IMNA701_1
(CYCLOOXYGENASE-2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.91A 4coxA-2pplA:
undetectable		 4coxA-2pplA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_B_IMNB701_1
(CYCLOOXYGENASE-2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.91A 4coxB-2pplA:
undetectable		 4coxB-2pplA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_D_IMND701_1
(CYCLOOXYGENASE-2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.90A 4coxD-2pplA:
undetectable		 4coxD-2pplA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 PHE A  96
ILE A 269
GLY A 268
THR A 273
 None
 0.87A 4ejjC-2pplA:
undetectable		 4ejjC-2pplA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_A_HFGA1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 179
VAL A 142
PRO A  46
THR A  37
GLY A  36
 None
 1.45A 4hvcA-2pplA:
undetectable		 4hvcA-2pplA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 210
TRP A  34
SER A 182
 CA  A 478 (-3.2A)
None
None
 1.02A 4lrhB-2pplA:
undetectable		 4lrhB-2pplA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 HIS A 170
TRP A 125
SER A 284
 None
 1.07A 4lrhD-2pplA:
undetectable		 4lrhD-2pplA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 ASP A 210
TRP A  34
SER A 182
 CA  A 478 (-3.2A)
None
None
 1.09A 4lrhF-2pplA:
undetectable		 4lrhF-2pplA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		3 / 3 LEU A 187
ARG A 189
MET A 325
 None
 0.99A 4m11C-2pplA:
undetectable		 4m11C-2pplA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 VAL A 360
ILE A 413
VAL A 410
LEU A 408
LEU A 377
 None
 1.48A 4m11D-2pplA:
undetectable		 4m11D-2pplA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLF_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLU A 179
VAL A 142
PRO A  46
THR A  37
GLY A  36
 None
 1.45A 4olfA-2pplA:
2.5		 4olfA-2pplA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A 383
TYR A 387
VAL A 410
GLY A 379
LEU A 408
 None
 1.25A 4ot2A-2pplA:
undetectable		 4ot2A-2pplA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.96A 4otyA-2pplA:
undetectable		 4otyA-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTY_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.94A 4otyB-2pplA:
undetectable		 4otyB-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.92A 4rrwC-2pplA:
undetectable		 4rrwC-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.88A 4rrwD-2pplA:
undetectable		 4rrwD-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 1.01A 4rrxA-2pplA:
undetectable		 4rrxA-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 1.00A 4rrxB-2pplA:
undetectable		 4rrxB-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.92A 4rrzC-2pplA:
undetectable		 4rrzC-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_D_LURD705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 209
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.88A 4rrzD-2pplA:
undetectable		 4rrzD-2pplA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A  25
VAL A 176
GLY A 178
ALA A 180
SER A 182
 None
None
CA  A 478 ( 4.9A)
None
None
 0.99A 5jvzA-2pplA:
undetectable		 5jvzA-2pplA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 ALA A 180
ILE A 121
ALA A 177
ILE A  78
LEU A  72
 None
 1.22A 6a5zD-2pplA:
undetectable		 6a5zD-2pplA:
9.28