SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ppq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		5 / 10 ALA A 264
ARG A 255
LEU A 257
LEU A 185
PRO A 186
 None
 0.92A 1cmcA-2ppqA:
undetectable
1cmcB-2ppqA:
undetectable		 1cmcA-2ppqA:
14.68
1cmcB-2ppqA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		5 / 10 ARG A 255
LEU A 257
GLU A 261
LEU A 185
PRO A 186
 None
 1.28A 1cmcA-2ppqA:
undetectable
1cmcB-2ppqA:
undetectable		 1cmcA-2ppqA:
14.68
1cmcB-2ppqA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		5 / 9 LEU A  12
LEU A  24
THR A  43
THR A  51
ILE A  49
 None
 1.44A 1hzeA-2ppqA:
undetectable
1hzeB-2ppqA:
undetectable		 1hzeA-2ppqA:
15.08
1hzeB-2ppqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		5 / 9 THR A  51
ILE A  49
LEU A  12
LEU A  24
THR A  43
 None
 1.44A 1hzeA-2ppqA:
undetectable
1hzeB-2ppqA:
undetectable		 1hzeA-2ppqA:
15.08
1hzeB-2ppqA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 8 ARG A 167
ILE A 170
ARG A 171
ILE A 174
 None
 0.82A 2bu8A-2ppqA:
undetectable		 2bu8A-2ppqA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 4 LEU A 268
PRO A 182
LEU A 219
ARG A 255
 None
 1.50A 2qd2A-2ppqA:
undetectable		 2qd2A-2ppqA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 7 THR A  51
LEU A  91
LEU A  66
LEU A  62
 None
 0.86A 3bgdB-2ppqA:
undetectable		 3bgdB-2ppqA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 4 LEU A 268
PRO A 182
LEU A 219
ARG A 255
 None
 1.47A 3hcoA-2ppqA:
undetectable		 3hcoA-2ppqA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		3 / 3 SER A 269
PHE A 307
LYS A 304
 None
 0.76A 3u88A-2ppqA:
undetectable		 3u88A-2ppqA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 8 ILE A  49
PRO A  80
ILE A 210
ASP A 211
 None
None
None
PO4  A 401 (-3.2A)
 0.39A 4dtaB-2ppqA:
17.8		 4dtaB-2ppqA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		5 / 12 LEU A 110
GLY A 208
LEU A  77
ASN A 198
LEU A 206
 None
None
None
PO4  A 401 (-2.8A)
None
 1.31A 4x61A-2ppqA:
undetectable		 4x61A-2ppqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BPH_A_ACTA403_0
(D-ALANINE--D-ALANINE
LIGASE)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 6 TYR A 176
ARG A 270
GLY A 271
LEU A 267
 None
 1.27A 5bphA-2ppqA:
undetectable		 5bphA-2ppqA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_1
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		3 / 3 ARG A 119
LYS A 245
GLU A 249
 None
 0.80A 5d0yA-2ppqA:
undetectable		 5d0yA-2ppqA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_A_NCTA402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 222
TRP A 148
TRP A 181
LEU A 177
 None
 1.35A 6cnjA-2ppqA:
0.6
6cnjB-2ppqA:
1.8		 6cnjA-2ppqA:
14.33
6cnjB-2ppqA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 8 TYR A 222
TRP A 148
TRP A 181
LEU A 177
 None
 1.40A 6cnjD-2ppqA:
undetectable
6cnjE-2ppqA:
undetectable		 6cnjD-2ppqA:
14.33
6cnjE-2ppqA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		4 / 7 TYR A 222
TRP A 148
TRP A 181
LEU A 177
 None
 1.32A 6cnkB-2ppqA:
undetectable
6cnkC-2ppqA:
undetectable		 6cnkB-2ppqA:
14.33
6cnkC-2ppqA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		5 / 12 ASP A 204
GLU A 205
HIS A 117
LEU A 110
GLY A 107
 MG  A 323 (-3.5A)
None
None
None
None
 1.42A 6f3mA-2ppqA:
undetectable		 6f3mA-2ppqA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_1
(-)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		5 / 12 ASP A 204
GLU A 205
HIS A 117
LEU A 110
GLY A 107
 MG  A 323 (-3.5A)
None
None
None
None
 1.42A 6f3mC-2ppqA:
undetectable		 6f3mC-2ppqA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 2ppq HOMOSERINE KINASE
(Agrobacterium
fabrum) 		3 / 3 TRP A 152
GLU A 157
GLU A 168
 None
 0.98A 6fhwA-2ppqA:
undetectable		 6fhwA-2ppqA:
13.71