SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ppv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 ILE A  32
ASP A  56
GLY A  11
VAL A  35
ALA A  53
 None
 1.10A 1axwA-2ppvA:
undetectable		 1axwA-2ppvA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 LEU A  22
GLY A  10
ASN A 194
ALA A  19
LEU A  18
 None
 0.93A 1bx4A-2ppvA:
8.4		 1bx4A-2ppvA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 ILE A 311
TYR A 312
HIS A 302
LEU A   8
ILE A  29
 None
 1.17A 1fmlB-2ppvA:
undetectable		 1fmlB-2ppvA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 6 PHE A 158
ILE A 192
ALA A 133
MET A 135
 None
 1.26A 1hk2A-2ppvA:
undetectable		 1hk2A-2ppvA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 ILE A 192
GLY A 183
GLY A 185
SER A 186
LEU A 212
 None
 1.22A 1i9gA-2ppvA:
4.7		 1i9gA-2ppvA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 9 ILE A 200
ILE A 171
ALA A 203
GLU A 175
ARG A 206
 None
 1.34A 1mrgA-2ppvA:
undetectable		 1mrgA-2ppvA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 7 ILE A 200
GLY A 199
ASN A 168
ARG A 206
 None
 0.88A 1oniG-2ppvA:
undetectable
1oniI-2ppvA:
undetectable		 1oniG-2ppvA:
18.24
1oniI-2ppvA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 4 SER A 281
ILE A 283
VAL A 273
THR A 224
 None
 1.20A 1u70A-2ppvA:
1.8		 1u70A-2ppvA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 PHE A 244
ILE A  29
ILE A  27
ALA A 315
ALA A 209
 None
 1.19A 2j0dA-2ppvA:
undetectable		 2j0dA-2ppvA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 11 LEU A 307
LEU A  18
LEU A  15
ILE A 249
THR A  30
 None
 1.20A 2qd3A-2ppvA:
2.3		 2qd3A-2ppvA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 10 ILE A 147
THR A 125
SER A 124
ASN A 194
VAL A 197
 None
 1.47A 3burB-2ppvA:
3.1		 3burB-2ppvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 9 ARG A 284
ILE A   9
ILE A 311
PRO A 210
ILE A 245
 None
 1.25A 3ekyB-2ppvA:
undetectable		 3ekyB-2ppvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 ASN A 303
HIS A 302
VAL A 217
 None
 0.76A 3elzB-2ppvA:
undetectable		 3elzB-2ppvA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 ARG A  78
ASP A  37
GLN A 220
 None
 0.92A 3lcvB-2ppvA:
2.4		 3lcvB-2ppvA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 8 ASP A  37
ASP A  56
GLY A  12
PRO A  54
 None
 1.04A 3s3mA-2ppvA:
undetectable		 3s3mA-2ppvA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 9 ALA A 209
ASP A 178
ILE A 171
ILE A   9
ILE A 180
 None
 0.96A 3s45A-2ppvA:
undetectable		 3s45A-2ppvA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 7 ASP A  85
GLY A  43
THR A  42
ILE A  45
 None
 0.88A 4acaC-2ppvA:
4.8		 4acaC-2ppvA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_1
(ADENOSINE KINASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 LEU A  22
GLY A  10
ASN A 194
VAL A  60
LEU A  18
 None
 0.92A 4dc3B-2ppvA:
9.1		 4dc3B-2ppvA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 LEU A 307
LEU A  18
LEU A  15
ILE A 249
THR A  30
 None
 1.23A 4f4dA-2ppvA:
undetectable		 4f4dA-2ppvA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 ILE A  32
ASP A  56
GLY A  11
VAL A  35
ALA A  53
 None
 1.17A 4foxD-2ppvA:
undetectable		 4foxD-2ppvA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 7 VAL A 121
ILE A 122
LEU A 204
LEU A 174
 None
 1.00A 4l1wA-2ppvA:
3.5		 4l1wA-2ppvA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 7 VAL A 229
ILE A 233
LEU A 314
LEU A 212
 None
 0.97A 4l1wA-2ppvA:
3.5		 4l1wA-2ppvA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 10 LEU A 307
LEU A  18
LEU A  15
ILE A 249
THR A  30
 None
 1.23A 4mk4A-2ppvA:
2.1		 4mk4A-2ppvA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 ARG A  20
GLU A  68
ARG A  23
 None
 0.95A 4mwvA-2ppvA:
undetectable		 4mwvA-2ppvA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 9 PHE A  75
ALA A  62
ALA A  63
LEU A  15
LEU A 115
 None
 1.32A 4or0A-2ppvA:
undetectable		 4or0A-2ppvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 LEU A 212
GLY A  14
LEU A  15
VAL A  33
VAL A   6
 None
 1.17A 4wnwA-2ppvA:
undetectable		 4wnwA-2ppvA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 7 VAL A 121
ILE A 122
LEU A 204
LEU A 174
 None
 1.01A 4xo7A-2ppvA:
3.7		 4xo7A-2ppvA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 9 ILE A 200
ILE A 171
ALA A 203
GLU A 175
ARG A 206
 None
 1.32A 4yp2B-2ppvA:
undetectable		 4yp2B-2ppvA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 11 LEU A 318
LEU A   8
LEU A 307
ILE A 249
LEU A  18
 None
 0.98A 4zowA-2ppvA:
undetectable		 4zowA-2ppvA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 9 ILE A 200
ILE A 171
ALA A 203
GLU A 175
ARG A 206
 None
 1.32A 5cf9B-2ppvA:
undetectable		 5cf9B-2ppvA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 7 ILE A  45
VAL A 114
ILE A  61
ASN A  99
 None
 0.96A 5hieC-2ppvA:
undetectable		 5hieC-2ppvA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 ILE A 122
PRO A 123
ILE A  32
 None
 0.43A 5hw8F-2ppvA:
undetectable		 5hw8F-2ppvA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		4 / 6 ILE A  32
ALA A 173
LEU A 174
ILE A 180
 None
 0.86A 5mvmB-2ppvA:
undetectable
5mvmC-2ppvA:
undetectable		 5mvmB-2ppvA:
13.15
5mvmC-2ppvA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 ALA A  63
VAL A 121
VAL A  33
ASP A  56
GLY A  10
 None
 1.19A 5x24A-2ppvA:
undetectable		 5x24A-2ppvA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		3 / 3 ASN A 290
VAL A 217
HIS A 302
 None
 0.64A 6a5yD-2ppvA:
undetectable		 6a5yD-2ppvA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 12 LEU A  92
GLY A  90
VAL A  35
ARG A  58
ILE A  57
 None
 1.34A 6bxnB-2ppvA:
undetectable		 6bxnB-2ppvA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 2ppv UNCHARACTERIZED
PROTEIN
(Staphylococcus
epidermidis) 		5 / 10 SER A 308
GLY A  21
ARG A  20
ALA A  63
LEU A 159
 None
 1.44A 6hqbA-2ppvA:
undetectable
6hqbJ-2ppvA:
undetectable		 6hqbA-2ppvA:
13.43
6hqbJ-2ppvA:
7.98