SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ppw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2ppw CONSERVED DOMAIN
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.93A 1v55A-2ppwA:
undetectable
1v55J-2ppwA:
undetectable		 1v55A-2ppwA:
16.47
1v55J-2ppwA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2ppw CONSERVED DOMAIN
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 THR A  70
ILE A   3
VAL A  65
ILE A   6
LEU A  60
 None
 1.21A 1z9hD-2ppwA:
undetectable		 1z9hD-2ppwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2ppw CONSERVED DOMAIN
PROTEIN
(Streptococcus
pneumoniae) 		4 / 7 GLN A 104
TYR A 102
TYR A  31
ILE A   3
 None
 1.30A 2ph9A-2ppwA:
undetectable
2ph9B-2ppwA:
undetectable		 2ph9A-2ppwA:
22.98
2ph9B-2ppwA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UH6_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2ppw CONSERVED DOMAIN
PROTEIN
(Streptococcus
pneumoniae) 		5 / 12 GLN A  46
LEU A  47
GLN A  51
ASP A 177
SER A 186
 None
 1.49A 5uh6C-2ppwA:
0.1		 5uh6C-2ppwA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2ppw CONSERVED DOMAIN
PROTEIN
(Streptococcus
pneumoniae) 		4 / 5 ILE A  58
LEU A  59
THR A  48
LEU A  47
 None
 0.86A 6nmpN-2ppwA:
undetectable
6nmpW-2ppwA:
undetectable		 6nmpN-2ppwA:
16.47
6nmpW-2ppwA:
13.43