SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ppy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 TYR A  32
GLY A  69
VAL A 144
PHE A  86
 None
 1.01A 1gsfC-2ppyA:
undetectable		 1gsfC-2ppyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 ALA A 122
LEU A 121
GLY A 150
GLY A 115
 None
 0.87A 1rukH-2ppyA:
undetectable
1rukL-2ppyA:
undetectable		 1rukH-2ppyA:
20.38
1rukL-2ppyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.77A 1rxcB-2ppyA:
undetectable		 1rxcB-2ppyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.76A 1rxcE-2ppyA:
undetectable		 1rxcE-2ppyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.77A 1rxcI-2ppyA:
undetectable		 1rxcI-2ppyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.75A 1rxcK-2ppyA:
undetectable		 1rxcK-2ppyA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		5 / 12 PRO A 138
GLY A  69
LEU A 117
GLY A 116
GLY A 115
 None
 0.88A 1uakA-2ppyA:
undetectable		 1uakA-2ppyA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		5 / 10 PHE A  36
GLY A 115
GLY A 116
THR A 112
GLU A 139
 None
 1.05A 3fw1A-2ppyA:
undetectable		 3fw1A-2ppyA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		5 / 11 GLY A  18
ALA A  20
ASP A  52
ILE A  53
GLN A 102
 None
 1.32A 3id5B-2ppyA:
undetectable		 3id5B-2ppyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		5 / 11 GLY A  18
ALA A  20
ASP A  52
ILE A  53
GLN A 102
 None
 1.32A 3id5F-2ppyA:
undetectable		 3id5F-2ppyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 5 LEU A 121
LEU A 137
GLY A 136
GLY A 114
 None
 0.82A 3si7C-2ppyA:
undetectable
3si7D-2ppyA:
undetectable		 3si7C-2ppyA:
22.08
3si7D-2ppyA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		5 / 7 GLY A 133
ALA A 132
ASP A 130
VAL A 187
ILE A 173
 None
 1.29A 3t3cA-2ppyA:
undetectable		 3t3cA-2ppyA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_2
(NEURAMINIDASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 5 LEU A 121
ARG A 126
ILE A 181
ARG A 162
 None
 1.37A 3ticA-2ppyA:
undetectable		 3ticA-2ppyA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.80A 4e1vA-2ppyA:
2.2		 4e1vA-2ppyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.79A 4e1vC-2ppyA:
undetectable		 4e1vC-2ppyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.78A 4e1vD-2ppyA:
undetectable		 4e1vD-2ppyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.75A 4e1vE-2ppyA:
2.4		 4e1vE-2ppyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_G_URFG1301_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.79A 4e1vG-2ppyA:
undetectable		 4e1vG-2ppyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 8 THR A 112
GLY A 133
GLN A 190
ILE A 135
 None
 0.78A 4e1vH-2ppyA:
undetectable		 4e1vH-2ppyA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 6 GLU A 109
ILE A  57
THR A 197
HIS A  23
 None
 1.43A 4qwpA-2ppyA:
0.0		 4qwpA-2ppyA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 4 VAL A  58
ALA A 120
PHE A  66
THR A 112
 None
 1.41A 4z4hA-2ppyA:
0.0		 4z4hA-2ppyA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 150
GLY A 147
THR A 151
ASN A 167
LEU A 121
 None
 1.20A 5kocB-2ppyA:
undetectable		 5kocB-2ppyA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		5 / 12 GLY A 147
ILE A  97
PHE A  40
GLY A 116
GLY A 115
 None
 0.83A 5koxA-2ppyA:
undetectable		 5koxA-2ppyA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 4 LEU A 237
LEU A 241
SER A 213
ALA A 211
 None
 1.11A 5uunA-2ppyA:
undetectable		 5uunA-2ppyA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		5 / 12 PRO A 138
GLY A  69
LEU A 117
GLY A 116
GLY A 115
 None
 0.93A 5wyqB-2ppyA:
undetectable		 5wyqB-2ppyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XOO_A_ADNA506_1
(GLYCOSAMINOGLYCAN
XYLOSYLKINASE)		 2ppy ENOYL-COA HYDRATASE
(Geobacillus
kaustophilus) 		4 / 6 TYR A  32
LEU A 121
GLU A 139
LEU A 137
 None
 1.43A 5xooA-2ppyA:
undetectable		 5xooA-2ppyA:
14.12