SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 12 GLU A 213
ASN A 210
ASP A   9
ILE A  41
SER A 183
 None
 1.38A 1q8jA-2pq0A:
undetectable		 1q8jA-2pq0A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 12 SER A 112
ASP A 134
ILE A 143
ARG A  88
THR A  91
 None
 1.45A 1s14A-2pq0A:
undetectable		 1s14A-2pq0A:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		3 / 3 LYS A 184
ASP A 176
ASN A 210
 None
 1.12A 2bm9A-2pq0A:
2.7		 2bm9A-2pq0A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		4 / 6 ASP A  11
LEU A  14
ASP A 211
LEU A 215
 None
 1.19A 3bj8C-2pq0A:
undetectable
3bj8D-2pq0A:
undetectable		 3bj8C-2pq0A:
21.40
3bj8D-2pq0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 12 LEU A  23
THR A  25
ARG A  30
GLY A  58
LEU A  57
 None
 1.32A 3j6pB-2pq0A:
4.1		 3j6pB-2pq0A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		3 / 3 PHE A 205
TYR A 249
LEU A  15
 None
 0.80A 3keeB-2pq0A:
undetectable		 3keeB-2pq0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 9 VAL A  63
SER A  64
ILE A  59
ALA A  40
ALA A 204
 None
 1.16A 3mdtA-2pq0A:
undetectable		 3mdtA-2pq0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		3 / 3 PHE A 205
TYR A 249
LEU A  15
 None
 0.77A 3sueB-2pq0A:
undetectable		 3sueB-2pq0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 12 ILE A 192
GLY A 219
ILE A 188
ASP A 201
LEU A 254
 None
 1.03A 3uj6A-2pq0A:
undetectable		 3uj6A-2pq0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 12 GLU A 213
ASP A 211
ASP A   9
SER A 183
GLN A  68
 None
 1.47A 4djeB-2pq0A:
undetectable		 4djeB-2pq0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 12 VAL A 222
GLY A 246
LEU A 251
LEU A 254
LEU A 256
 None
 0.89A 4o1zA-2pq0A:
undetectable		 4o1zA-2pq0A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 11 SER A 112
ASP A 134
ILE A 143
ARG A  88
THR A  91
 None
 1.35A 4urnA-2pq0A:
undetectable		 4urnA-2pq0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		5 / 11 SER A 112
ASP A 134
ILE A 143
ARG A  88
THR A  91
 None
 1.49A 4urnC-2pq0A:
undetectable		 4urnC-2pq0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		4 / 6 LEU A 148
ASP A 176
ILE A 113
HIS A 116
 None
 0.94A 4xi3C-2pq0A:
undetectable		 4xi3C-2pq0A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		3 / 3 LEU A  82
VAL A 177
ASP A 176
 None
 0.62A 5x23A-2pq0A:
undetectable		 5x23A-2pq0A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 2pq0 HYPOTHETICAL
CONSERVED PROTEIN
GK1056
(Geobacillus
kaustophilus) 		4 / 4 VAL A 231
GLY A 208
ASP A 207
ASP A   9
 None
 1.12A 6cjkC-2pq0A:
undetectable		 6cjkC-2pq0A:
23.25