SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pq6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 6 ALA A 449
TRP A 381
LEU A 452
TRP A 414
 None
 1.16A 1gahA-2pq6A:
undetectable		 1gahA-2pq6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 8 PHE A  37
ILE A 474
PRO A   9
LEU A 479
 None
 0.86A 1hmyA-2pq6A:
3.4		 1hmyA-2pq6A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 4 SER A 251
ILE A 252
VAL A 223
THR A 131
 None
 0.75A 1u70A-2pq6A:
undetectable		 1u70A-2pq6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		3 / 3 TRP A 381
LEU A 258
LYS A  27
 None
 1.49A 1yajK-2pq6A:
undetectable		 1yajK-2pq6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 9 LEU A 262
LEU A 261
ILE A 255
LEU A  28
TYR A 145
 None
 1.24A 2f7aA-2pq6A:
undetectable		 2f7aA-2pq6A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 10 ILE A 242
ILE A 252
LEU A 231
ASN A 232
ASN A 235
 None
 1.12A 2nnhB-2pq6A:
undetectable		 2nnhB-2pq6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 5 LEU A  25
LEU A  28
LEU A  34
MET A  13
 None
 1.04A 2oaxF-2pq6A:
undetectable		 2oaxF-2pq6A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		3 / 3 GLY A  74
ASP A  73
SER A  94
 None
 0.67A 2qhfA-2pq6A:
undetectable		 2qhfA-2pq6A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 6 LEU A 313
ILE A 331
ILE A 372
LEU A 395
 None
 0.97A 2xkwB-2pq6A:
undetectable		 2xkwB-2pq6A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 5 ILE A  39
HIS A  33
ARG A  35
GLY A  36
 None
 1.26A 3b9mA-2pq6A:
undetectable		 3b9mA-2pq6A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 8 HIS A  21
GLY A  20
ASN A 382
PHE A 146
 None
 1.06A 3ccfA-2pq6A:
4.0		 3ccfA-2pq6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D9L_A_ACTA501_0
(CTD-PEPTIDE
RNA-BINDING PROTEIN
16)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 5 PRO A  24
ILE A  22
PRO A  15
TYR A  16
 None
 1.21A 3d9lA-2pq6A:
undetectable
3d9lY-2pq6A:
undetectable		 3d9lA-2pq6A:
13.49
3d9lY-2pq6A:
4.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 LEU A 237
ALA A 456
SER A 466
THR A 460
 None
 1.03A 3ozkB-2pq6A:
undetectable		 3ozkB-2pq6A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 LEU A  32
VAL A 123
THR A 228
THR A 227
ILE A 249
 None
 1.30A 3sp9B-2pq6A:
undetectable		 3sp9B-2pq6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		3 / 3 TYR A 467
LEU A 452
LYS A 453
 None
 0.64A 3sueD-2pq6A:
undetectable		 3sueD-2pq6A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 PHE A  66
ASN A  67
ILE A  39
HIS A  33
 None
 0.93A 3t01A-2pq6A:
undetectable		 3t01A-2pq6A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 5 LEU A 314
ALA A 317
MET A 308
PHE A 343
 None
 1.28A 3uq6A-2pq6A:
5.8		 3uq6A-2pq6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 6 VAL A 473
LEU A 470
ILE A 255
VAL A 123
 None
 0.75A 4a9kA-2pq6A:
undetectable		 4a9kA-2pq6A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 5 VAL A 473
LEU A 470
ILE A 255
VAL A 123
 None
 0.94A 4a9kB-2pq6A:
undetectable		 4a9kB-2pq6A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 ASN A  47
ARG A  50
LEU A  51
GLY A  20
 None
 0.60A 4cp3A-2pq6A:
undetectable
4cp3B-2pq6A:
undetectable		 4cp3A-2pq6A:
13.84
4cp3B-2pq6A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 VAL A  88
LEU A  91
ASN A 382
MET A 128
 None
 0.95A 4e1gB-2pq6A:
undetectable		 4e1gB-2pq6A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 6 LEU A 237
ALA A 456
SER A 466
THR A 460
 None
 1.06A 4ikiB-2pq6A:
undetectable		 4ikiB-2pq6A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 LEU A 237
ALA A 456
SER A 466
THR A 460
 None
 1.04A 4ikjA-2pq6A:
undetectable
4ikjB-2pq6A:
undetectable		 4ikjA-2pq6A:
14.25
4ikjB-2pq6A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 LEU A 237
ALA A 456
SER A 466
THR A 460
 None
 1.04A 4iklA-2pq6A:
undetectable
4iklB-2pq6A:
undetectable		 4iklA-2pq6A:
14.25
4iklB-2pq6A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 9 TYR A 145
CYH A 126
HIS A  21
ILE A 252
 None
 1.17A 4jvlA-2pq6A:
undetectable		 4jvlA-2pq6A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N16_A_CHDA301_0
(CARBONIC ANHYDRASE 2)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 8 HIS A 378
PHE A 202
THR A 306
THR A 305
 None
 0.90A 4n16A-2pq6A:
undetectable		 4n16A-2pq6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 PHE A 302
GLY A 303
SER A 304
ILE A 330
PHE A 375
 None
 1.15A 4u8vB-2pq6A:
undetectable		 4u8vB-2pq6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 PHE A 302
GLY A 303
SER A 304
ILE A 330
PHE A 375
 None
 1.12A 4u8yB-2pq6A:
undetectable		 4u8yB-2pq6A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 LEU A 289
ALA A 358
LEU A 356
ILE A 330
 None
 0.82A 4ubsA-2pq6A:
undetectable		 4ubsA-2pq6A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 ARG A  96
ASP A 221
ARG A 160
GLU A 164
 None
 0.89A 5bs8A-2pq6A:
undetectable
5bs8C-2pq6A:
undetectable
5bs8D-2pq6A:
undetectable		 5bs8A-2pq6A:
21.40
5bs8C-2pq6A:
21.40
5bs8D-2pq6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 ARG A  96
ASP A 221
ARG A 160
GLU A 164
 None
 0.89A 5btaA-2pq6A:
undetectable
5btaC-2pq6A:
undetectable
5btaD-2pq6A:
3.0		 5btaA-2pq6A:
21.40
5btaC-2pq6A:
21.40
5btaD-2pq6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 7 ASP A 221
ARG A 160
GLU A 164
ARG A  96
 None
 0.94A 5btfA-2pq6A:
undetectable
5btfB-2pq6A:
2.3
5btfC-2pq6A:
undetectable		 5btfA-2pq6A:
21.40
5btfB-2pq6A:
18.48
5btfC-2pq6A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 MET A 128
THR A 131
ALA A 134
GLU A 137
ILE A  71
 None
 0.95A 5gs4A-2pq6A:
undetectable		 5gs4A-2pq6A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		3 / 3 LYS A 292
LYS A 325
SER A 326
 None
 1.34A 5odiA-2pq6A:
3.8		 5odiA-2pq6A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 THR A 305
ASP A 402
ASN A 382
GLY A  20
PHE A 400
 None
 1.34A 6exiA-2pq6A:
4.6		 6exiA-2pq6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 THR A 305
THR A 306
ASP A 402
ASN A 382
GLY A  20
 None
 1.48A 6exiA-2pq6A:
4.6		 6exiA-2pq6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_D_ADND502_0
(ADENOSYLHOMOCYSTEINA
SE)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 THR A 305
ASP A 402
ASN A 382
GLY A  20
PHE A 400
 None
 1.36A 6exiD-2pq6A:
3.7		 6exiD-2pq6A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		4 / 5 ILE A  14
THR A 131
THR A  44
LEU A  91
 None
 1.08A 6f3mD-2pq6A:
4.0		 6f3mD-2pq6A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 2pq6 UDP-GLUCURONOSYL/UDP
-GLUCOSYLTRANSFERASE
(Medicago
truncatula) 		5 / 12 VAL A 185
ASP A 172
PHE A 170
TRP A 187
PHE A 162
 None
 1.43A 6iblB-2pq6A:
undetectable		 6iblB-2pq6A:
20.04