SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pq7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 8 ASP A  66
HIS A  65
HIS A 111
HIS A  36
 FE  A 220 (-2.5A)
FE  A 221 (-3.4A)
FE  A 220 ( 3.4A)
FE  A 221 ( 3.3A)
 0.74A 1ei6D-2pq7A:
undetectable		 1ei6D-2pq7A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		5 / 6 HIS A  65
HIS A  36
HIS A  79
HIS A 111
ASP A 131
 FE  A 221 (-3.4A)
FE  A 221 ( 3.3A)
FE  A 220 (-3.4A)
FE  A 220 ( 3.4A)
FE  A 221 (-2.6A)
 1.15A 1fweC-2pq7A:
undetectable		 1fweC-2pq7A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		5 / 10 GLY A  83
ALA A  84
HIS A  79
HIS A 111
HIS A  65
 None
None
FE  A 220 (-3.4A)
FE  A 220 ( 3.4A)
FE  A 221 (-3.4A)
 1.23A 3boyA-2pq7A:
0.0
3boyC-2pq7A:
0.0		 3boyA-2pq7A:
22.17
3boyC-2pq7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		5 / 10 HIS A 111
HIS A  65
GLY A  83
ALA A  84
HIS A  79
 FE  A 220 ( 3.4A)
FE  A 221 (-3.4A)
None
None
FE  A 220 (-3.4A)
 1.24A 3boyA-2pq7A:
0.0
3boyB-2pq7A:
0.0		 3boyA-2pq7A:
22.17
3boyB-2pq7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		5 / 10 HIS A 111
HIS A  65
GLY A  83
ALA A  84
HIS A  79
 FE  A 220 ( 3.4A)
FE  A 221 (-3.4A)
None
None
FE  A 220 (-3.4A)
 1.24A 3boyB-2pq7A:
0.0
3boyC-2pq7A:
0.0		 3boyB-2pq7A:
22.17
3boyC-2pq7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		5 / 12 PHE A  96
ASP A  54
LEU A  63
LEU A  13
ILE A  16
 None
 1.23A 3ko0M-2pq7A:
undetectable
3ko0N-2pq7A:
undetectable
3ko0O-2pq7A:
undetectable
3ko0P-2pq7A:
undetectable		 3ko0M-2pq7A:
18.18
3ko0N-2pq7A:
18.18
3ko0O-2pq7A:
18.18
3ko0P-2pq7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		3 / 3 LEU A   6
MET A   1
ASP A 131
 None
None
FE  A 221 (-2.6A)
 0.58A 4j7xB-2pq7A:
undetectable		 4j7xB-2pq7A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLY A  95
ILE A  60
LYS A  57
GLN A  56
 None
 1.11A 4ma8C-2pq7A:
undetectable		 4ma8C-2pq7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		5 / 6 HIS A  65
HIS A  36
HIS A  79
HIS A 111
ASP A 131
 FE  A 221 (-3.4A)
FE  A 221 ( 3.3A)
FE  A 220 (-3.4A)
FE  A 220 ( 3.4A)
FE  A 221 (-2.6A)
 1.04A 4ubpC-2pq7A:
undetectable		 4ubpC-2pq7A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.25A 5hm8A-2pq7A:
undetectable		 5hm8A-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.24A 5hm8B-2pq7A:
undetectable		 5hm8B-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.24A 5hm8C-2pq7A:
undetectable		 5hm8C-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.24A 5hm8D-2pq7A:
undetectable		 5hm8D-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.24A 5hm8E-2pq7A:
undetectable		 5hm8E-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.24A 5hm8F-2pq7A:
undetectable		 5hm8F-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.25A 5hm8G-2pq7A:
undetectable		 5hm8G-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 5 GLU A 187
GLU A 192
THR A 193
LEU A 133
 None
 1.23A 5hm8H-2pq7A:
undetectable		 5hm8H-2pq7A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 6 HIS A  32
HIS A 111
HIS A  79
HIS A  36
 PO4  A 223 (-3.6A)
FE  A 220 ( 3.4A)
FE  A 220 (-3.4A)
FE  A 221 ( 3.3A)
 1.08A 5nelB-2pq7A:
undetectable
5nelC-2pq7A:
undetectable		 5nelB-2pq7A:
20.16
5nelC-2pq7A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2pq7 PREDICTED HD
SUPERFAMILY
HYDROLASE
(uncultured
Thermotogales
bacterium) 		4 / 6 LEU A 133
VAL A  40
THR A  37
LEU A 122
 None
 0.98A 5tudD-2pq7A:
undetectable		 5tudD-2pq7A:
18.97