SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		6 / 9 TYR A  94
PHE A 108
GLY A 128
TYR A 130
GLU A 207
ARG A 210
 None
 0.50A 1mrgA-2pqiA:
24.2		 1mrgA-2pqiA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		5 / 8 TYR A  94
GLY A 128
TYR A 130
GLU A 207
ARG A 210
 None
 0.48A 1mrjA-2pqiA:
24.5		 1mrjA-2pqiA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ0_A_ACRA801_2
(ALPHA-GLUCOSIDASE
(ALPHA-GLUCOSIDASE
SUSB))		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		5 / 9 TRP A  72
VAL A  96
HIS A 115
GLU A 107
GLY A 102
 None
 1.50A 2zq0A-2pqiA:
0.0		 2zq0A-2pqiA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWL_A_ASCA303_0
(DIOSCORIN 5)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		5 / 10 GLN A  59
VAL A  61
VAL A 280
PHE A 249
ALA A 252
 None
 1.17A 4twlA-2pqiA:
undetectable		 4twlA-2pqiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWL_B_ASCB304_0
(DIOSCORIN 5)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		5 / 10 GLN A  59
VAL A  61
VAL A 280
PHE A 249
ALA A 252
 None
 1.09A 4twlB-2pqiA:
undetectable		 4twlB-2pqiA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		4 / 8 TYR A  74
THR A  85
TRP A 105
TRP A  72
 None
 1.32A 4tzcB-2pqiA:
0.3
4tzcD-2pqiA:
0.1		 4tzcB-2pqiA:
17.84
4tzcD-2pqiA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		5 / 9 PHE A 108
GLY A 128
TYR A 130
GLU A 207
ARG A 210
 None
 0.41A 4yp2B-2pqiA:
24.5		 4yp2B-2pqiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		5 / 9 PHE A 108
GLY A 128
TYR A 130
GLU A 207
ARG A 210
 None
 0.40A 5cf9B-2pqiA:
24.5		 5cf9B-2pqiA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		3 / 3 ASP A 219
PHE A  27
ARG A 146
 None
 1.15A 5yw0A-2pqiA:
undetectable		 5yw0A-2pqiA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2pqi RIBOSOME-INACTIVATIN
G PROTEIN 3
(Zea
mays) 		4 / 4 GLY A 235
LEU A 139
VAL A 238
GLU A 207
 None
 1.38A 5yw0A-2pqiA:
undetectable		 5yw0A-2pqiA:
21.94