SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pqq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		6 / 12 LEU A 113
LEU A 104
LEU A  22
GLY A 105
HIS A 106
LEU A  83
 None
 1.44A 2ouzA-2pqqA:
undetectable		 2ouzA-2pqqA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 7 LEU A  57
ARG A  89
THR A  90
ALA A  91
 None
 1.24A 3mbgA-2pqqA:
undetectable
3mbgB-2pqqA:
undetectable		 3mbgA-2pqqA:
24.84
3mbgB-2pqqA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 9 ILE A  78
ARG A  89
ASP A  42
PHE A  38
LEU A  57
 None
 1.50A 3mjrA-2pqqA:
undetectable		 3mjrA-2pqqA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 4 LEU A 101
SER A  27
LEU A  47
LEU A  37
 None
 1.11A 4n09A-2pqqA:
undetectable		 4n09A-2pqqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		4 / 5 LEU A 101
SER A  27
LEU A  47
LEU A  37
 None
 1.13A 4n09B-2pqqA:
undetectable		 4n09B-2pqqA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 GLU A  98
ALA A  32
LEU A  31
GLU A  52
LEU A 101
 None
 0.93A 4wg0C-2pqqA:
undetectable
4wg0D-2pqqA:
undetectable
4wg0E-2pqqA:
undetectable		 4wg0C-2pqqA:
7.19
4wg0D-2pqqA:
7.19
4wg0E-2pqqA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 GLU A  98
ALA A  32
LEU A  31
GLU A  52
LEU A 101
 None
 0.93A 4wg0E-2pqqA:
undetectable
4wg0F-2pqqA:
undetectable
4wg0G-2pqqA:
undetectable		 4wg0E-2pqqA:
7.19
4wg0F-2pqqA:
7.19
4wg0G-2pqqA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 GLU A  52
LEU A 101
GLU A  98
ALA A  32
LEU A  31
 None
 1.14A 4wg0H-2pqqA:
undetectable
4wg0I-2pqqA:
undetectable
4wg0J-2pqqA:
undetectable		 4wg0H-2pqqA:
7.19
4wg0I-2pqqA:
7.19
4wg0J-2pqqA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2pqq PUTATIVE
TRANSCRIPTIONAL
REGULATOR
(Streptomyces
coelicolor) 		5 / 11 GLU A  98
ALA A  32
LEU A  31
GLU A  52
LEU A 101
 None
 0.96A 4wg0K-2pqqA:
undetectable
4wg0L-2pqqA:
undetectable
4wg0M-2pqqA:
undetectable		 4wg0K-2pqqA:
7.19
4wg0L-2pqqA:
7.19
4wg0M-2pqqA:
7.19