SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		4 / 8 PHE A  64
THR A  50
VAL A  42
LEU A  65
 None
None
None
FMN  A 500 (-4.4A)
 0.82A 2zujA-2pr5A:
undetectable		 2zujA-2pr5A:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		11 / 12 VAL A  28
ASN A  37
ASN A  61
CYH A  62
ARG A  63
GLN A  66
ASN A  94
ASN A 104
LEU A 106
ILE A 108
GLN A 123
 None
FMN  A 500 (-3.8A)
FMN  A 500 (-3.2A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-4.2A)
FMN  A 500 (-3.9A)
 0.38A 4kukA-2pr5A:
17.1		 4kukA-2pr5A:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		5 / 12 VAL A  28
ASN A  61
LEU A 106
ILE A 108
GLN A 123
 None
FMN  A 500 (-3.2A)
FMN  A 500 (-4.1A)
FMN  A 500 (-4.2A)
FMN  A 500 (-3.9A)
 1.17A 4kukA-2pr5A:
17.1		 4kukA-2pr5A:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		7 / 9 LEU A  65
VAL A  75
ILE A  78
LEU A  82
ILE A  92
PHE A 119
GLY A 121
 FMN  A 500 (-4.4A)
FMN  A 500 (-4.6A)
FMN  A 500 (-4.1A)
FMN  A 500 (-4.5A)
FMN  A 500 ( 4.6A)
FMN  A 500 ( 4.8A)
FMN  A 500 (-3.9A)
 0.24A 4kukA-2pr5A:
17.1		 4kukA-2pr5A:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4KUO_A_RBFA500_1
(BLUE-LIGHT
PHOTORECEPTOR)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		11 / 12 VAL A  28
ASN A  37
ASN A  61
CYH A  62
ARG A  63
GLN A  66
LEU A  82
ASN A  94
ASN A 104
LEU A 106
GLN A 123
 None
FMN  A 500 (-3.8A)
FMN  A 500 (-3.2A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.5A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
 0.50A 4kuoA-2pr5A:
17.2		 4kuoA-2pr5A:
33.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		8 / 12 CYH A  62
ARG A  63
GLN A  66
ASN A  94
ASN A 104
LEU A 106
GLY A 121
GLN A 123
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.9A)
 0.56A 4r38A-2pr5A:
17.9		 4r38A-2pr5A:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		5 / 8 ASN A  61
LEU A  65
VAL A  75
ILE A  92
PHE A 119
 FMN  A 500 (-3.2A)
FMN  A 500 (-4.4A)
FMN  A 500 (-4.6A)
FMN  A 500 ( 4.6A)
FMN  A 500 ( 4.8A)
 0.67A 4r38A-2pr5A:
17.9		 4r38A-2pr5A:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		9 / 12 ASN A  61
CYH A  62
ARG A  63
GLN A  66
ASN A  94
ASN A 104
LEU A 106
GLY A 121
GLN A 123
 FMN  A 500 (-3.2A)
FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.9A)
 0.57A 4r38B-2pr5A:
18.0		 4r38B-2pr5A:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		8 / 12 CYH A  62
ARG A  63
GLN A  66
ASN A  94
ASN A 104
LEU A 106
GLY A 121
GLN A 123
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.9A)
 0.54A 4r38C-2pr5A:
17.9		 4r38C-2pr5A:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		5 / 9 ASN A  61
LEU A  65
VAL A  75
ILE A  92
PHE A 119
 FMN  A 500 (-3.2A)
FMN  A 500 (-4.4A)
FMN  A 500 (-4.6A)
FMN  A 500 ( 4.6A)
FMN  A 500 ( 4.8A)
 0.72A 4r38C-2pr5A:
17.9		 4r38C-2pr5A:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		8 / 12 CYH A  62
ARG A  63
GLN A  66
ASN A  94
ASN A 104
LEU A 106
GLY A 121
GLN A 123
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.9A)
 0.56A 4r38D-2pr5A:
18.0		 4r38D-2pr5A:
40.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		5 / 12 ALA A  81
ILE A  92
ASN A 104
LEU A 106
GLN A 123
 None
FMN  A 500 ( 4.6A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
 1.20A 4r3aA-2pr5A:
15.2		 4r3aA-2pr5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		8 / 12 CYH A  62
ARG A  63
GLN A  66
ILE A  92
ASN A  94
ASN A 104
LEU A 106
GLN A 123
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 (-3.1A)
FMN  A 500 ( 4.6A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
 0.43A 4r3aA-2pr5A:
15.2		 4r3aA-2pr5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		5 / 10 ASN A  61
LEU A  65
GLN A  66
VAL A  75
PHE A 119
 FMN  A 500 (-3.2A)
FMN  A 500 (-4.4A)
FMN  A 500 (-3.1A)
FMN  A 500 (-4.6A)
FMN  A 500 ( 4.8A)
 0.58A 4r3aB-2pr5A:
14.7		 4r3aB-2pr5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_B_RBFB402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2pr5 BLUE-LIGHT
PHOTORECEPTOR
(Bacillus
subtilis) 		8 / 12 CYH A  62
ARG A  63
ILE A  92
ASN A  94
ASN A 104
LEU A 106
GLY A 121
GLN A 123
 FMN  A 500 (-3.5A)
FMN  A 500 (-3.8A)
FMN  A 500 ( 4.6A)
FMN  A 500 (-3.1A)
FMN  A 500 (-3.7A)
FMN  A 500 (-4.1A)
FMN  A 500 (-3.9A)
FMN  A 500 (-3.9A)
 0.47A 4r3aB-2pr5A:
14.7		 4r3aB-2pr5A:
19.76