SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2prd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		5 / 11 THR A  61
LEU A  69
VAL A 105
GLY A  71
VAL A  87
 None
 1.17A 1akdA-2prdA:
undetectable		 1akdA-2prdA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		4 / 5 LEU A 162
VAL A 165
CYH A 168
ALA A  63
 None
 1.11A 1mz9D-2prdA:
undetectable		 1mz9D-2prdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		4 / 4 LEU A 162
VAL A 165
CYH A 168
ALA A  63
 None
 1.08A 1mz9E-2prdA:
undetectable		 1mz9E-2prdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		5 / 12 LEU A  69
GLY A  71
VAL A  73
LEU A  92
LEU A 162
 None
 1.41A 1nhzA-2prdA:
undetectable		 1nhzA-2prdA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		3 / 3 ASP A  65
GLU A  31
TYR A 139
 None
None
SO4  A 175 (-4.3A)
 0.81A 1wsvA-2prdA:
undetectable		 1wsvA-2prdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		5 / 11 THR A  61
LEU A  69
VAL A 105
GLY A  71
VAL A  87
 None
 1.16A 2a1nA-2prdA:
undetectable		 2a1nA-2prdA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		5 / 10 THR A  61
LEU A  69
VAL A 105
GLY A  71
VAL A  87
 None
 1.19A 2cp4A-2prdA:
undetectable		 2cp4A-2prdA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		4 / 7 TYR A 139
TYR A  51
TYR A  55
ILE A 132
 SO4  A 175 (-4.3A)
None
None
None
 1.33A 2xz5B-2prdA:
undetectable
2xz5E-2prdA:
undetectable		 2xz5B-2prdA:
25.91
2xz5E-2prdA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		3 / 3 GLU A 164
VAL A 165
CYH A 168
 None
 0.97A 3fbxA-2prdA:
undetectable		 3fbxA-2prdA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		3 / 3 LYS A 140
ARG A  43
ASP A  65
 SO4  A 175 (-2.9A)
SO4  A 175 (-3.1A)
None
 1.43A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		3 / 3 LYS A 148
ARG A  43
ASP A  67
 SO4  A 175 ( 4.5A)
SO4  A 175 (-3.1A)
None
 1.37A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		3 / 3 LYS A 148
ARG A  43
ASP A  70
 SO4  A 175 ( 4.5A)
SO4  A 175 (-3.1A)
None
 1.44A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		4 / 8 TYR A 139
TYR A  51
TYR A  55
ILE A 132
 SO4  A 175 (-4.3A)
None
None
None
 1.31A 4bqtC-2prdA:
undetectable
4bqtD-2prdA:
undetectable		 4bqtC-2prdA:
25.91
4bqtD-2prdA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 2prd PYROPHOSPHATE
PHOSPHOHYDROLASE
(Thermus
thermophilus) 		3 / 3 TYR A 139
ARG A  43
LYS A 140
 SO4  A 175 (-4.3A)
SO4  A 175 (-3.1A)
SO4  A 175 (-2.9A)
 1.41A 4wq5B-2prdA:
undetectable		 4wq5B-2prdA:
19.94