SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2prf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 8 LEU A  62
PHE A  60
THR A  88
VAL A  97
LEU A  22
 None
 1.37A 1fiqC-2prfA:
undetectable		 1fiqC-2prfA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXD_A_DR7A102_1
(POL PROTEIN)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 11 LEU A  62
GLY A  42
ILE A  21
PHE A  35
VAL A  37
 None
 0.82A 2fxdA-2prfA:
undetectable		 2fxdA-2prfA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 10 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.31A 3fhjA-2prfA:
undetectable		 3fhjA-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 10 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.38A 3fhjB-2prfA:
undetectable		 3fhjB-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 10 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.37A 3fhjC-2prfA:
undetectable		 3fhjC-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 10 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.35A 3fhjE-2prfA:
undetectable		 3fhjE-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 9 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.33A 3fi0A-2prfA:
undetectable		 3fi0A-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 9 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.39A 3fi0C-2prfA:
undetectable		 3fi0C-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 9 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.38A 3fi0K-2prfA:
undetectable		 3fi0K-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 9 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.26A 3fi0L-2prfA:
undetectable		 3fi0L-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 9 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.34A 3fi0M-2prfA:
undetectable		 3fi0M-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 9 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.36A 3fi0N-2prfA:
undetectable		 3fi0N-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 9 GLY A 107
GLN A 105
ILE A  87
VAL A 113
VAL A 112
 None
 1.31A 3fi0R-2prfA:
undetectable		 3fi0R-2prfA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		3 / 3 ALA A  36
VAL A  37
GLN A  41
 None
 0.67A 3of4B-2prfA:
undetectable		 3of4B-2prfA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 2prf PROFILIN IA
(Acanthamoeba
sp.) 		5 / 12 ALA A  84
GLY A  82
GLY A  79
HIS A  66
LEU A  62
 None
 0.87A 5gwxA-2prfA:
undetectable		 5gwxA-2prfA:
20.46