SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pro'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		3 / 3 ASN A  83
PHE A  44
VAL A  81
 None
 0.77A 1kijA-2proA:
undetectable		 1kijA-2proA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		6 / 12 ARG A  82
ILE A  40
GLY A  45
ALA A  66
ALA A  65
VAL A  64
 None
 1.06A 2oc8A-2proA:
undetectable		 2oc8A-2proA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 6 SER A  68
GLN A  47
SER A  87
GLN A  90
 None
 1.05A 3si7C-2proA:
0.0
3si7D-2proA:
0.0		 3si7C-2proA:
21.51
3si7D-2proA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_D_ACTD5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 6 SER A  87
GLN A  90
SER A  68
GLN A  47
 None
 1.11A 3si7C-2proA:
0.0
3si7D-2proA:
0.0		 3si7C-2proA:
21.51
3si7D-2proA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 LEU A  27
GLN A  22
ASP A  15
MET A  12
GLY A  17
 None
 1.37A 4j7xA-2proA:
undetectable		 4j7xA-2proA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 LEU A  27
GLN A  22
ASP A  15
MET A  12
GLY A  17
 None
 1.35A 4j7xF-2proA:
undetectable		 4j7xF-2proA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		4 / 7 VAL A 121
GLN A  92
LEU A  88
SER A  87
 None
 0.87A 4zphA-2proA:
undetectable
4zphB-2proA:
undetectable		 4zphA-2proA:
18.80
4zphB-2proA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 VAL A 128
ARG A  82
ILE A  40
GLY A  45
ALA A  66
 None
 1.12A 6c2mA-2proA:
undetectable		 6c2mA-2proA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		5 / 12 VAL A 128
ARG A  82
ILE A  40
GLY A  45
ALA A  66
 None
 1.13A 6c2mB-2proA:
undetectable		 6c2mB-2proA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		6 / 12 VAL A 128
ARG A  82
GLY A  45
ALA A  66
ALA A  65
VAL A  64
 None
 1.38A 6c2mC-2proA:
undetectable		 6c2mC-2proA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 2pro ALPHA-LYTIC PROTEASE
(Lysobacter
enzymogenes) 		6 / 12 VAL A 128
ARG A  82
ILE A  40
GLY A  45
ALA A  66
ALA A  65
 None
 1.25A 6c2mD-2proA:
undetectable		 6c2mD-2proA:
17.86