SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2prz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  21
TYR A  36
ILE A 206
ILE A 198
 None
 0.93A 2q8hA-2przA:
undetectable		 2q8hA-2przA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 187
GLY A 156
ILE A 129
ILE A  70
VAL A 181
 None
 0.99A 3fpjA-2przA:
2.4		 3fpjA-2przA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  48
ALA A  15
PHE A  11
ASN A  39
 None
 1.37A 3vaqA-2przA:
undetectable		 3vaqA-2przA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 165
GLY A 222
LEU A 195
GLU A 215
 None
 1.12A 3w9tB-2przA:
undetectable		 3w9tB-2przA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 165
GLY A 222
LEU A 195
GLU A 215
 None
 1.12A 3w9tE-2przA:
undetectable		 3w9tE-2przA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 165
GLY A 222
LEU A 195
GLU A 215
 None
 1.11A 3w9tF-2przA:
undetectable		 3w9tF-2przA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		4 / 5 SER A 176
VAL A 166
GLY A 222
ALA A 223
 None
 0.94A 5k50A-2przA:
undetectable		 5k50A-2przA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  78
VAL A 118
ILE A 146
VAL A 154
ILE A 129
 None
 0.94A 5mueA-2przA:
undetectable		 5mueA-2przA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2prz OROTATE
PHOSPHORIBOSYLTRANSF
ERASE 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  40
VAL A 133
THR A 135
LEU A 202
 None
OMP  A 450 (-4.4A)
OMP  A 450 (-2.8A)
None
 0.94A 5tudD-2przA:
undetectable		 5tudD-2przA:
19.21