SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ps2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 8 SER A 292
SER A 141
PHE A 192
ILE A 139
 None
 1.15A 1gm7A-2ps2A:
undetectable
1gm7B-2ps2A:
undetectable		 1gm7A-2ps2A:
18.18
1gm7B-2ps2A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		3 / 3 LEU A 213
PRO A 214
LEU A 217
 None
 0.46A 1hrkA-2ps2A:
3.7		 1hrkA-2ps2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 5 LEU A 201
LEU A 210
LEU A 212
LEU A 221
 None
 1.14A 1yajD-2ps2A:
undetectable		 1yajD-2ps2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		3 / 3 LEU A 213
PRO A 214
LEU A 217
 None
 0.46A 2qd5B-2ps2A:
3.6		 2qd5B-2ps2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 5 GLY A  20
GLY A  21
PHE A  56
PHE A  34
 None
 0.98A 2qr2A-2ps2A:
undetectable
2qr2B-2ps2A:
undetectable		 2qr2A-2ps2A:
21.05
2qr2B-2ps2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 8 TYR A  60
THR A  37
LEU A  16
THR A  74
 None
 1.20A 2v0zO-2ps2A:
undetectable		 2v0zO-2ps2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 7 PHE A 339
GLY A 355
ASP A 336
ARG A 359
 None
 1.23A 3aruA-2ps2A:
3.8		 3aruA-2ps2A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		5 / 9 ALA A 306
PHE A 339
LEU A 363
VAL A 362
ILE A  38
 None
 1.33A 3claA-2ps2A:
undetectable		 3claA-2ps2A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_2
(PROTEASE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 6 PRO A 358
ILE A  47
GLY A  49
VAL A  87
 None
 0.83A 3n3iA-2ps2A:
undetectable		 3n3iA-2ps2A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 5 ARG A 281
ASP A  95
ASP A  96
ARG A  89
 None
 1.25A 3naiC-2ps2A:
undetectable		 3naiC-2ps2A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		3 / 3 LEU A 213
PRO A 214
LEU A 217
 None
 0.45A 3w1wB-2ps2A:
3.7		 3w1wB-2ps2A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 6 PRO A 173
GLY A 171
LEU A 201
GLU A 204
 None
 0.93A 3zqtA-2ps2A:
undetectable		 3zqtA-2ps2A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1477_0
(MJ0495-LIKE PROTEIN)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 6 THR A 277
GLY A 279
ILE A 270
LEU A 128
 None
 1.11A 4ac9C-2ps2A:
2.8		 4ac9C-2ps2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 6 THR A 277
GLY A 279
ILE A 270
LEU A 128
 None
 1.10A 4acaC-2ps2A:
3.0		 4acaC-2ps2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		5 / 11 GLY A 279
ALA A 273
LYS A 272
ILE A 257
ILE A 266
 None
 1.03A 4dt8A-2ps2A:
undetectable		 4dt8A-2ps2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		5 / 10 GLY A 279
ALA A 273
LYS A 272
ILE A 257
ILE A 266
 None
 1.10A 4dt8B-2ps2A:
undetectable		 4dt8B-2ps2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 4 PRO A 137
LEU A 138
ILE A 341
ARG A 327
 None
 1.37A 4f4dA-2ps2A:
undetectable		 4f4dA-2ps2A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		5 / 12 GLY A 337
ILE A 303
ALA A 335
ALA A 307
ASP A 114
 None
 1.09A 4kicA-2ps2A:
undetectable		 4kicA-2ps2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		5 / 12 GLY A 337
ILE A 303
ALA A 335
ALA A 307
ASP A 114
 None
 1.10A 4kicB-2ps2A:
undetectable		 4kicB-2ps2A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 8 SER A  53
SER A 271
ILE A  61
GLU A 102
 None
 1.06A 4ms4A-2ps2A:
3.2		 4ms4A-2ps2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		5 / 12 ILE A 315
GLN A 282
THR A 106
VAL A 110
LEU A 311
 None
 1.32A 4qzuA-2ps2A:
undetectable		 4qzuA-2ps2A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		5 / 12 GLU A 222
ASP A 196
ALA A 183
PHE A 192
ILE A 142
 MG  A 401 (-3.2A)
MG  A 401 (-2.6A)
None
None
None
 1.17A 4xe5A-2ps2A:
undetectable		 4xe5A-2ps2A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A506_1
(HOMOSPERMIDINE
SYNTHASE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 6 ARG A 280
ASP A  88
VAL A 110
ASP A 109
 None
 1.38A 4xqeA-2ps2A:
undetectable		 4xqeA-2ps2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 6 ARG A 280
ASP A  88
VAL A 110
ASP A 109
 None
 1.37A 4xqeB-2ps2A:
undetectable		 4xqeB-2ps2A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 5 THR A 277
GLY A 279
HIS A 310
ASP A 109
 None
 1.15A 5c0oH-2ps2A:
2.2		 5c0oH-2ps2A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 5 GLU A  52
ASP A 302
VAL A  14
ALA A  36
 None
 1.29A 5dl9A-2ps2A:
undetectable		 5dl9A-2ps2A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_A_STIA302_1
(DEOXYCYTIDINE KINASE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		5 / 12 ILE A 341
GLU A 126
ARG A 327
PHE A 305
CYH A 125
 None
 1.20A 5mqtA-2ps2A:
0.8		 5mqtA-2ps2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
(Aspergillus
oryzae) 		4 / 6 PRO A 137
GLY A 164
TYR A 162
GLU A 191
 None
 1.11A 6gqiA-2ps2A:
undetectable		 6gqiA-2ps2A:
23.78