SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ps3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 PHE A 180
LEU A 184
ILE A 150
ALA A 151
ALA A 155
 None
 1.05A 1cbsA-2ps3A:
undetectable		 1cbsA-2ps3A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 11 GLY A 160
VAL A  28
LEU A  77
LEU A 173
LEU A 177
 None
 0.82A 1mx1A-2ps3A:
undetectable		 1mx1A-2ps3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 GLY A 160
VAL A  28
LEU A  77
LEU A 173
LEU A 177
 None
 0.77A 1mx1D-2ps3A:
undetectable		 1mx1D-2ps3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 GLY A 160
VAL A  28
LEU A  77
LEU A 173
LEU A 177
 None
 0.91A 1mx1F-2ps3A:
undetectable		 1mx1F-2ps3A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 LEU A 281
LEU A  53
SER A  31
PHE A  88
ALA A  87
 None
 0.96A 1n5xA-2ps3A:
1.5		 1n5xA-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 LEU A 281
SER A  31
PHE A  88
VAL A  81
ALA A  87
 None
 0.92A 1n5xA-2ps3A:
1.5		 1n5xA-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 LEU A 281
LEU A  53
SER A  31
PHE A  88
ALA A  87
 None
 0.96A 1n5xB-2ps3A:
undetectable		 1n5xB-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 LEU A 281
SER A  31
PHE A  88
VAL A  81
ALA A  87
 None
 0.92A 1n5xB-2ps3A:
undetectable		 1n5xB-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		3 / 3 TRP A  80
LEU A  77
LYS A 161
 None
 1.12A 1yajK-2ps3A:
undetectable		 1yajK-2ps3A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 8 SER A  31
VAL A  35
VAL A  81
HIS A 143
 None
 0.86A 2ddwA-2ps3A:
undetectable		 2ddwA-2ps3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 PHE A 180
LEU A 184
ILE A 150
ALA A 151
ALA A 155
 None
 1.07A 2fr3A-2ps3A:
undetectable		 2fr3A-2ps3A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 PHE A 217
LEU A 113
LEU A 296
LEU A 184
TYR A 292
 None
 1.39A 2prgB-2ps3A:
undetectable		 2prgB-2ps3A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 8 SER A  31
THR A 154
LEU A 113
THR A  49
 None
 0.97A 2v0zO-2ps3A:
undetectable		 2v0zO-2ps3A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 6 MET A  89
SER A  31
PRO A  83
GLY A  82
 None
 1.37A 2y7pA-2ps3A:
undetectable		 2y7pA-2ps3A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 8 SER A  31
PHE A  88
VAL A  81
ALA A  87
 None
 0.96A 3ax7A-2ps3A:
0.9		 3ax7A-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 8 SER A  31
PHE A  88
VAL A  81
ALA A  87
 None
 0.94A 3ax9A-2ps3A:
0.9		 3ax9A-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 5 PHE A 259
PRO A 261
VAL A 263
ALA A 255
 None
 1.27A 4w5oA-2ps3A:
undetectable		 4w5oA-2ps3A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 5 PHE A 259
PRO A 261
VAL A 263
ALA A 255
 None
 1.29A 4z4cA-2ps3A:
undetectable		 4z4cA-2ps3A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 5 PHE A 259
PRO A 261
VAL A 263
ALA A 255
 None
 1.29A 4z4dA-2ps3A:
2.1		 4z4dA-2ps3A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 5 PHE A 259
PRO A 261
VAL A 263
ALA A 255
 None
 1.29A 4z4eA-2ps3A:
undetectable		 4z4eA-2ps3A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		4 / 5 TYR A 303
GLY A 211
TYR A 203
GLY A 223
 None
 1.00A 5ayfA-2ps3A:
undetectable		 5ayfA-2ps3A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		5 / 12 PHE A 217
LEU A 113
LEU A 296
LEU A 184
TYR A 292
 None
 1.37A 5ycpA-2ps3A:
undetectable		 5ycpA-2ps3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA
(Escherichia
coli) 		3 / 3 GLY A 288
THR A 290
GLU A 294
 None
 0.62A 6b58A-2ps3A:
undetectable		 6b58A-2ps3A:
19.11