SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2psm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_2
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 2psm INTERLEUKIN-15
RECEPTOR ALPHA CHAIN
(Mus
musculus) 		4 / 5 ILE F  10
HIS F  56
TYR F  20
VAL F  17
 None
 1.05A 4s0vA-2psmF:
undetectable		 4s0vA-2psmF:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 2psm INTERLEUKIN-15
INTERLEUKIN-15
RECEPTOR ALPHA CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 4 ILE A  21
ARG F  27
TYR A  54
GLU A  53
 None
 1.32A 4zzbD-2psmA:
2.4		 4zzbD-2psmA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 2psm INTERLEUKIN-15
INTERLEUKIN-15
RECEPTOR ALPHA CHAIN
(Mus
musculus) 		5 / 10 LEU A  25
ALA F  38
LEU A  45
LEU A  47
LEU A  91
 None
 1.45A 5dxeB-2psmA:
undetectable		 5dxeB-2psmA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUQ_A_ACTA1278_0
(NAD(P)H
DEHYDROGENASE
[QUINONE] 1)		 2psm INTERLEUKIN-15
INTERLEUKIN-15
RECEPTOR ALPHA CHAIN
(Mus
musculus;
Mus
musculus) 		4 / 5 HIS A  52
SER F  41
ILE A  50
TYR A  54
 None
 1.47A 5fuqA-2psmA:
0.0
5fuqB-2psmA:
0.0		 5fuqA-2psmA:
18.80
5fuqB-2psmA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 2psm INTERLEUKIN-15
INTERLEUKIN-15
RECEPTOR ALPHA CHAIN
(Mus
musculus) 		5 / 10 LEU A  25
ALA F  38
LEU A  45
LEU A  47
LEU A  91
 None
 1.48A 5hyrA-2psmA:
undetectable		 5hyrA-2psmA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2psm INTERLEUKIN-15
RECEPTOR ALPHA CHAIN
(Mus
musculus) 		4 / 4 ASN F  31
SER F   9
ALA F  13
VAL F  29
 None
 1.29A 5nm5A-2psmF:
undetectable		 5nm5A-2psmF:
11.60