SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2psq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_A_STIA201_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 None
 0.68A 1iepA-2psqA:
32.1		 1iepA-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1IEP_B_STIB202_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.69A 1iepB-2psqA:
32.0		 1iepB-2psqA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 9 LEU A 487
GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
 None
 0.78A 1muoA-2psqA:
7.9		 1muoA-2psqA:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_A_STIA3_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.60A 1opjA-2psqA:
31.3		 1opjA-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1OPJ_B_STIB4_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.66A 1opjB-2psqA:
31.3		 1opjB-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 7 VAL A 562
TYR A 566
CYH A 622
ARG A 625
 None
None
None
SO4  A 303 ( 2.9A)
 1.29A 1t46A-2psqA:
34.3		 1t46A-2psqA:
43.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 VAL A 495
ALA A 515
GLU A 534
LEU A 617
HIS A 624
 None
 0.47A 1uwjA-2psqA:
7.5		 1uwjA-2psqA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 VAL A 495
ALA A 515
GLU A 534
LEU A 617
HIS A 624
 None
 0.47A 1uwjB-2psqA:
7.5		 1uwjB-2psqA:
25.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
ALA A 515
ALA A 567
GLY A 570
LEU A 633
 None
 0.54A 1xbbA-2psqA:
34.7		 1xbbA-2psqA:
33.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 11 GLY A 488
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
ASP A 644
 None
 0.91A 2evaA-2psqA:
27.6		 2evaA-2psqA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
TYR A 566
ASN A 631
ASP A 644
 None
 1.04A 2fumB-2psqA:
26.5		 2fumB-2psqA:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
TYR A 566
ASN A 631
ASP A 644
 None
 0.75A 2fumC-2psqA:
24.9		 2fumC-2psqA:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_A_1N1A501_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 None
 0.75A 2gqgA-2psqA:
35.3		 2gqgA-2psqA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2GQG_B_1N1B502_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 None
 0.47A 2gqgB-2psqA:
35.0		 2gqgB-2psqA:
35.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_A_STIA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.74A 2hyyA-2psqA:
32.2		 2hyyA-2psqA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_B_STIB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.71A 2hyyB-2psqA:
26.4		 2hyyB-2psqA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
GLU A 534
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.65A 2hyyC-2psqA:
32.4		 2hyyC-2psqA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HYY_D_STID600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.66A 2hyyD-2psqA:
32.3		 2hyyD-2psqA:
37.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ITO_A_IREA2020_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
 None
 0.99A 2itoA-2psqA:
33.6		 2itoA-2psqA:
31.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
GLY A 488
GLU A 534
VAL A 564
TYR A 566
LEU A 633
ASP A 644
 None
 0.84A 2ivuA-2psqA:
37.8		 2ivuA-2psqA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
ASP A 644
 None
 0.64A 2ivuA-2psqA:
37.8		 2ivuA-2psqA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OIQ_A_STIA1001_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.71A 2oiqA-2psqA:
30.6		 2oiqA-2psqA:
32.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
ILE A 548
GLY A 570
LEU A 633
ASP A 644
 None
 0.58A 2y7jA-2psqA:
22.0		 2y7jA-2psqA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 10 VAL A 495
ALA A 515
ILE A 548
GLY A 570
LEU A 633
ASP A 644
 None
 0.65A 2y7jB-2psqA:
27.1		 2y7jB-2psqA:
24.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 8 LEU A 487
ALA A 515
GLY A 570
LEU A 633
 None
 0.49A 2yfxA-2psqA:
31.6		 2yfxA-2psqA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZVA_A_1N1A513_1
(TYROSINE-PROTEIN
KINASE LYN)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
GLU A 534
MET A 538
GLY A 570
LEU A 633
ALA A 643
 None
 0.73A 2zvaA-2psqA:
34.1		 2zvaA-2psqA:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 MET A 537
ALA A 618
PHE A 645
GLY A 613
LEU A 627
 None
 1.41A 3aodC-2psqA:
undetectable		 3aodC-2psqA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.71A 3cs9A-2psqA:
32.5		 3cs9A-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_A_NILA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
LEU A 633
ALA A 643
 None
 0.58A 3cs9A-2psqA:
32.5		 3cs9A-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.60A 3cs9B-2psqA:
32.4		 3cs9B-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_B_NILB600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
 None
 0.55A 3cs9B-2psqA:
32.4		 3cs9B-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_C_NILC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
HIS A 624
ALA A 643
 None
 0.68A 3cs9C-2psqA:
31.2		 3cs9C-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.68A 3cs9D-2psqA:
31.0		 3cs9D-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CS9_D_NILD600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
 None
 0.52A 3cs9D-2psqA:
31.0		 3cs9D-2psqA:
35.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 None
 0.37A 3g0eA-2psqA:
32.1		 3g0eA-2psqA:
44.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 None
 0.43A 3g0fA-2psqA:
25.0		 3g0fA-2psqA:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 10 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 None
 0.36A 3g0fB-2psqA:
33.8		 3g0fB-2psqA:
44.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_A_1N1A1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.53A 3g5dA-2psqA:
32.5		 3g5dA-2psqA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G5D_B_1N1B1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.68A 3g5dB-2psqA:
32.5		 3g5dB-2psqA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GVU_A_STIA1001_1
(TYROSINE-PROTEIN
KINASE ABL2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.63A 3gvuA-2psqA:
32.0		 3gvuA-2psqA:
38.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_A_0LIA1_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
HIS A 624
LEU A 633
ALA A 643
 None
 0.72A 3ik3A-2psqA:
32.1		 3ik3A-2psqA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3IK3_B_0LIB2_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
HIS A 624
LEU A 633
ALA A 643
 None
 0.70A 3ik3B-2psqA:
31.8		 3ik3B-2psqA:
33.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K54_A_1N1A1_1
(TYROSINE-PROTEIN
KINASE BTK)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 None
 0.88A 3k54A-2psqA:
31.6		 3k54A-2psqA:
32.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_A_STIA2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.66A 3k5vA-2psqA:
31.5		 3k5vA-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3K5V_B_STIB2_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.65A 3k5vB-2psqA:
31.1		 3k5vB-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.66A 3ms9A-2psqA:
31.9		 3ms9A-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MS9_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.68A 3ms9B-2psqA:
32.0		 3ms9B-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_A_STIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.66A 3mssA-2psqA:
32.0		 3mssA-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
ALA A 643
 None
 0.52A 3mssB-2psqA:
32.0		 3mssB-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.61A 3mssB-2psqA:
32.0		 3mssB-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_B_STIB1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.61A 3mssB-2psqA:
32.0		 3mssB-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_C_STIC1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.67A 3mssC-2psqA:
31.9		 3mssC-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MSS_D_STID1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.74A 3mssD-2psqA:
32.0		 3mssD-2psqA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OEZ_A_STIA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.71A 3oezA-2psqA:
30.2		 3oezA-2psqA:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OXZ_A_0LIA1_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
GLY A 570
HIS A 624
ALA A 643
 None
 0.61A 3oxzA-2psqA:
32.3		 3oxzA-2psqA:
34.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
MET A 538
ILE A 541
GLY A 570
LEU A 633
ALA A 643
 None
 0.58A 3pyyA-2psqA:
26.6		 3pyyA-2psqA:
36.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
ALA A 643
 None
 0.55A 3pyyA-2psqA:
26.6		 3pyyA-2psqA:
36.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_A_STIA3_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
MET A 538
ILE A 541
GLY A 570
ALA A 643
 None
 0.64A 3pyyA-2psqA:
26.6		 3pyyA-2psqA:
36.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PYY_B_STIB4_1
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.59A 3pyyB-2psqA:
32.1		 3pyyB-2psqA:
36.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_A_1N1A601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.67A 3qlgA-2psqA:
31.0		 3qlgA-2psqA:
32.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QLG_B_1N1B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
ASP A 644
 None
 0.63A 3qlgB-2psqA:
32.3		 3qlgB-2psqA:
32.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 515
GLU A 534
ILE A 548
TYR A 566
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 None
 1.07A 3rgfA-2psqA:
21.0		 3rgfA-2psqA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
ILE A 548
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 None
 0.86A 3rgfA-2psqA:
21.0		 3rgfA-2psqA:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_A_1N1A1_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
TYR A 566
GLY A 570
LEU A 633
 None
 0.51A 3sxrA-2psqA:
32.1		 3sxrA-2psqA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SXR_B_1N1B2_1
(CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
TYR A 566
GLY A 570
LEU A 633
 None
 0.48A 3sxrB-2psqA:
31.9		 3sxrB-2psqA:
31.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
VAL A 564
GLY A 570
 None
 0.46A 3wzdA-2psqA:
34.6		 3wzdA-2psqA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
ILE A 541
VAL A 564
GLY A 570
LEU A 617
HIS A 624
 None
 0.65A 3wzeA-2psqA:
34.9		 3wzeA-2psqA:
48.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
GLU A 534
LEU A 617
HIS A 624
ARG A 625
LEU A 633
ALA A 643
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
None
 0.92A 3zosA-2psqA:
23.7		 3zosA-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
LYS A 517
GLU A 534
LEU A 617
HIS A 624
ARG A 625
ALA A 643
 None
None
None
None
None
None
SO4  A 303 ( 2.9A)
None
 0.96A 3zosA-2psqA:
23.7		 3zosA-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 9 MET A 538
ILE A 547
ILE A 548
TYR A 566
ILE A 642
 None
 0.83A 3zosA-2psqA:
23.7		 3zosA-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
ILE A 548
LEU A 617
HIS A 624
LEU A 633
ALA A 643
 None
 0.72A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
LYS A 517
GLU A 534
ILE A 548
LEU A 617
HIS A 624
ALA A 643
 None
 0.83A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 487
MET A 538
ILE A 547
TYR A 566
ILE A 642
 None
 0.70A 3zosB-2psqA:
23.7		 3zosB-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AG8_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
VAL A 564
GLY A 570
LEU A 633
 None
 0.51A 4ag8A-2psqA:
35.2		 4ag8A-2psqA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGC_A_AXIA2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
VAL A 564
GLY A 570
LEU A 633
 None
 0.55A 4agcA-2psqA:
34.5		 4agcA-2psqA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AGD_A_B49A2000_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
ALA A 515
LYS A 517
VAL A 564
GLY A 570
LEU A 633
 None
 0.48A 4agdA-2psqA:
34.3		 4agdA-2psqA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANQ_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
ALA A 515
GLY A 570
LEU A 633
ALA A 643
 None
 0.52A 4anqA-2psqA:
31.7		 4anqA-2psqA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ANS_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
ALA A 515
GLY A 570
LEU A 633
ALA A 643
 None
 0.55A 4ansA-2psqA:
31.6		 4ansA-2psqA:
36.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
VAL A 564
GLY A 570
LEU A 617
HIS A 624
 None
 0.69A 4asdA-2psqA:
26.3		 4asdA-2psqA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
TYR A 566
LEU A 633
ALA A 643
 None
 1.07A 4bkjA-2psqA:
29.5		 4bkjA-2psqA:
33.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
LEU A 633
ALA A 643
 None
 0.89A 4bkjB-2psqA:
29.7		 4bkjB-2psqA:
33.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 5 VAL A 495
ILE A 547
TYR A 566
ILE A 642
 None
 0.58A 4c8bA-2psqA:
26.9		 4c8bA-2psqA:
26.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 487
GLY A 488
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
 None
 0.88A 4ckiA-2psqA:
38.0		 4ckiA-2psqA:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 487
GLY A 490
VAL A 495
ALA A 515
TYR A 566
ALA A 567
GLY A 570
 None
 1.25A 4ckiA-2psqA:
38.0		 4ckiA-2psqA:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
GLY A 493
VAL A 495
ALA A 515
VAL A 564
TYR A 566
 None
 0.92A 4ckiA-2psqA:
38.0		 4ckiA-2psqA:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 11 LEU A 487
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
GLY A 570
LEU A 633
 None
 0.46A 4ckiA-2psqA:
38.0		 4ckiA-2psqA:
44.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 487
GLY A 488
ALA A 515
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 None
 0.72A 4ckjA-2psqA:
38.3		 4ckjA-2psqA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 487
VAL A 495
ALA A 515
VAL A 564
TYR A 566
ALA A 567
LEU A 633
 None
 0.38A 4ckjA-2psqA:
38.3		 4ckjA-2psqA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CSV_A_STIA1265_1
(SRC-ABL TYROSINE
KINASE ANCESTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
TYR A 566
LEU A 633
ALA A 643
 None
 0.61A 4csvA-2psqA:
25.9		 4csvA-2psqA:
34.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXY_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.66A 4mxyB-2psqA:
27.6		 4mxyB-2psqA:
31.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MXZ_B_DB8B601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.66A 4mxzB-2psqA:
27.6		 4mxzB-2psqA:
31.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 11 LEU A 487
VAL A 495
ALA A 515
LYS A 517
ASN A 631
LEU A 633
ASP A 644
 None
 0.52A 4o0sA-2psqA:
27.0		 4o0sA-2psqA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 6 VAL A 495
ALA A 515
LYS A 517
LEU A 633
 None
 0.68A 4o0uA-2psqA:
8.0		 4o0uA-2psqA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
LYS A 517
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.97A 4otwA-2psqA:
29.1		 4otwA-2psqA:
28.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 ALA A 515
GLU A 534
MET A 538
VAL A 564
LEU A 617
CYH A 622
ARG A 625
ALA A 643
 None
None
None
None
None
None
SO4  A 303 ( 2.9A)
None
 0.70A 4qrcA-2psqA:
36.4		 4qrcA-2psqA:
66.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 8 LEU A 487
VAL A 495
ILE A 548
ALA A 567
HIS A 624
LEU A 633
 None
 0.56A 4qrcA-2psqA:
36.4		 4qrcA-2psqA:
66.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
CYH A 622
LEU A 633
 None
 0.49A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
LYS A 517
GLU A 534
MET A 538
CYH A 622
 None
 0.66A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU A 487
VAL A 562
TYR A 566
ARG A 625
 None
None
None
SO4  A 303 ( 2.9A)
 0.55A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 5 LEU A 487
VAL A 562
TYR A 566
ARG A 664
 None
 0.97A 4r7iA-2psqA:
27.4		 4r7iA-2psqA:
45.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 ALA A 515
GLU A 534
MET A 538
ILE A 541
VAL A 564
ALA A 567
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 None
 0.56A 4tyjA-2psqA:
36.6		 4tyjA-2psqA:
63.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TYJ_A_0LIA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 6 LEU A 487
VAL A 495
ILE A 547
ILE A 642
 None
 0.42A 4tyjA-2psqA:
36.6		 4tyjA-2psqA:
63.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 10 LEU A 487
VAL A 495
GLU A 534
ILE A 547
VAL A 562
TYR A 566
ARG A 625
ILE A 642
 None
None
None
None
None
None
SO4  A 303 ( 2.9A)
None
 0.87A 4u0iA-2psqA:
33.8		 4u0iA-2psqA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 10 LEU A 487
VAL A 495
GLU A 534
VAL A 562
TYR A 566
ARG A 625
ILE A 547
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
 1.43A 4u0iA-2psqA:
33.8		 4u0iA-2psqA:
45.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 11 LEU A 487
GLY A 493
VAL A 495
ALA A 515
TYR A 566
GLY A 570
ASN A 631
LEU A 633
ALA A 643
 None
 0.85A 4u5jA-2psqA:
33.9		 4u5jA-2psqA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
ALA A 515
TYR A 566
GLY A 570
LEU A 633
 None
 0.53A 4u5jB-2psqA:
32.3		 4u5jB-2psqA:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
ILE A 541
LEU A 617
CYH A 622
LEU A 633
ALA A 643
 None
 0.79A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
ILE A 541
LEU A 617
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 None
 0.71A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
ALA A 515
GLU A 534
LEU A 617
CYH A 622
LEU A 633
ALA A 643
 None
 0.64A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
VAL A 564
LEU A 617
CYH A 622
HIS A 624
LEU A 633
ALA A 643
 None
 0.60A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 7 VAL A 495
MET A 538
ILE A 548
ALA A 567
ARG A 625
ILE A 642
 None
None
None
None
SO4  A 303 ( 2.9A)
None
 1.07A 4uxqA-2psqA:
36.1		 4uxqA-2psqA:
63.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 ALA A 515
GLU A 534
MET A 537
MET A 538
ILE A 541
VAL A 564
ALA A 567
LEU A 617
HIS A 624
ALA A 643
 None
 0.65A 4v01A-2psqA:
35.8		 4v01A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 9 LEU A 487
VAL A 495
ILE A 548
TYR A 566
CYH A 622
ARG A 625
LEU A 633
ILE A 642
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
None
 0.92A 4v01A-2psqA:
35.8		 4v01A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 ALA A 515
GLU A 534
MET A 537
MET A 538
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 None
 0.70A 4v01B-2psqA:
35.5		 4v01B-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 9 LEU A 487
VAL A 495
ILE A 541
ILE A 548
TYR A 566
LEU A 633
ILE A 642
 None
 0.60A 4v01B-2psqA:
35.5		 4v01B-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 9 LEU A 487
VAL A 495
LYS A 517
ILE A 541
TYR A 566
ILE A 642
 None
 0.87A 4v01B-2psqA:
35.5		 4v01B-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 9 VAL A 495
ILE A 541
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
None
None
SO4  A 303 ( 2.9A)
None
None
 0.89A 4v01B-2psqA:
35.5		 4v01B-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 None
 0.65A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
VAL A 564
ALA A 567
HIS A 624
ALA A 643
GLY A 646
 None
 1.20A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 8 ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
SO4  A 303 ( 2.9A)
None
None
 1.15A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 8 MET A 538
ILE A 548
TYR A 566
LEU A 633
ILE A 642
 None
 0.46A 4v04A-2psqA:
36.0		 4v04A-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 10 LEU A 487
VAL A 495
MET A 538
ILE A 548
TYR A 566
ARG A 625
LEU A 633
ILE A 642
 None
None
None
None
None
SO4  A 303 ( 2.9A)
None
None
 0.93A 4v04B-2psqA:
36.2		 4v04B-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		9 / 12 ALA A 515
GLU A 534
MET A 537
VAL A 564
ALA A 567
LEU A 617
CYH A 622
HIS A 624
ALA A 643
 None
 0.73A 4v04B-2psqA:
36.2		 4v04B-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
GLU A 534
VAL A 564
ALA A 567
HIS A 624
ALA A 643
GLY A 646
 None
 1.25A 4v04B-2psqA:
36.2		 4v04B-2psqA:
73.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XEY_A_1N1A601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
MET A 538
GLY A 570
LEU A 633
ALA A 643
 None
 0.72A 4xeyA-2psqA:
34.4		 4xeyA-2psqA:
36.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_A_1N1A601_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.53A 4xliA-2psqA:
35.3		 4xliA-2psqA:
35.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XLI_B_1N1B600_1
(NON-SPECIFIC
PROTEIN-TYROSINE
KINASE)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 LEU A 487
ALA A 515
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.58A 4xliB-2psqA:
35.2		 4xliB-2psqA:
35.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		4 / 10 ALA A 515
GLY A 570
LEU A 633
ALA A 643
 None
 0.40A 5ajqB-2psqA:
23.9		 5ajqB-2psqA:
25.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
TYR A 566
GLY A 570
LEU A 633
ALA A 643
 None
 0.72A 5bvwA-2psqA:
30.6		 5bvwA-2psqA:
31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
LEU A 633
 None
 0.69A 5h2uA-2psqA:
29.3		 5h2uA-2psqA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_B_1N1B501_1
(PROTEIN-TYROSINE
KINASE 6)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
LEU A 633
 None
 0.71A 5h2uB-2psqA:
29.6		 5h2uB-2psqA:
32.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5H2U_D_1N1D504_1
(PROTEIN-TYROSINE
KINASE 6)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 LEU A 487
VAL A 495
ALA A 515
LYS A 517
GLY A 570
LEU A 633
 None
 0.67A 5h2uD-2psqA:
29.4		 5h2uD-2psqA:
32.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
ILE A 548
ALA A 567
PHE A 645
GLY A 646
 None
 1.03A 5hesA-2psqA:
26.3		 5hesA-2psqA:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
ILE A 548
TYR A 566
ALA A 567
PHE A 645
 None
 0.83A 5hesA-2psqA:
26.3		 5hesA-2psqA:
26.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
GLU A 534
ILE A 548
TYR A 566
GLY A 570
LEU A 633
 None
 0.57A 5i9xA-2psqA:
32.4		 5i9xA-2psqA:
31.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5I9Y_A_1N1A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 ALA A 515
LYS A 517
GLU A 534
MET A 538
TYR A 566
GLY A 570
LEU A 633
 None
 1.02A 5i9yA-2psqA:
32.2		 5i9yA-2psqA:
31.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 11 LEU A 487
VAL A 495
ALA A 515
TYR A 566
ALA A 567
LEU A 633
 None
 0.44A 5lvnA-2psqA:
26.8		 5lvnA-2psqA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_B_ADNB401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 9 GLY A 488
VAL A 495
ALA A 515
ILE A 548
ASN A 571
 None
 0.75A 5lw1B-2psqA:
21.0		 5lw1B-2psqA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 10 GLY A 488
VAL A 495
ALA A 515
ILE A 548
ASN A 571
 None
 0.86A 5lw1E-2psqA:
20.5		 5lw1E-2psqA:
12.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MO4_A_NILA601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 ALA A 515
MET A 538
ILE A 541
HIS A 624
LEU A 633
ALA A 643
 None
 0.67A 5mo4A-2psqA:
26.6		 5mo4A-2psqA:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_0
(REGULATORY PROTEIN
TETR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 12 MET A 735
MET A 736
GLU A 615
LEU A 753
CYH A 606
 None
 1.40A 5vlmE-2psqA:
undetectable		 5vlmE-2psqA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		5 / 9 LEU A 487
VAL A 495
LYS A 517
ILE A 548
ASP A 644
 None
 1.13A 5yf9X-2psqA:
23.7		 5yf9X-2psqA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_D_1E8D1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		6 / 12 VAL A 495
ALA A 515
LYS A 517
GLY A 570
LEU A 633
ASP A 644
 None
 0.97A 5yu9D-2psqA:
28.8		 5yu9D-2psqA:
13.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		11 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
TYR A 566
ALA A 567
GLY A 570
ALA A 643
 None
 0.53A 5zv2A-2psqA:
36.8		 5zv2A-2psqA:
45.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		10 / 12 LEU A 487
GLY A 488
VAL A 495
ALA A 515
GLU A 534
MET A 538
VAL A 564
ALA A 567
GLY A 570
ALA A 643
 None
 0.62A 5zv2B-2psqA:
36.7		 5zv2B-2psqA:
45.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSD_A_1N1A901_0
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		8 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
TYR A 566
GLY A 570
LEU A 633
 None
 0.80A 6bsdA-2psqA:
30.1		 6bsdA-2psqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.63A 6hd4A-2psqA:
31.4		 6hd4A-2psqA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.62A 6hd4B-2psqA:
31.0		 6hd4B-2psqA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_0
(TYROSINE-PROTEIN
KINASE ABL1)		 2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens) 		7 / 12 LEU A 487
VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
 None
 0.71A 6hd6B-2psqA:
31.0		 6hd6B-2psqA:
14.25