SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2psy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 2psy KALLIKREIN-5
(Homo
sapiens) 		8 / 8 HIS A  57
ASP A 189
SER A 190
GLN A 192
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.57A 1aq7A-2psyA:
38.4		 1aq7A-2psyA:
47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		6 / 9 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.42A 1bcuH-2psyA:
17.9		 1bcuH-2psyA:
34.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
 0.55A 1dwcH-2psyA:
33.9		 1dwcH-2psyA:
34.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 2psy KALLIKREIN-5
(Homo
sapiens) 		4 / 8 ALA A  44
LEU A  33
LEU A  40
LEU A  67
 None
 0.93A 1ereE-2psyA:
undetectable		 1ereE-2psyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 2psy KALLIKREIN-5
(Homo
sapiens) 		4 / 8 ALA A  44
LEU A  33
LEU A  40
LEU A  67
 None
 0.93A 1ereF-2psyA:
undetectable		 1ereF-2psyA:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		7 / 12 HIS A  57
ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.71A 1etrH-2psyA:
33.5		 1etrH-2psyA:
34.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2psy KALLIKREIN-5
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.43A 1f5lA-2psyA:
11.3		 1f5lA-2psyA:
35.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.34A 1tnlA-2psyA:
38.6		 1tnlA-2psyA:
47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 12 LEU A 155
GLY A 140
GLN A  30
VAL A 199
ILE A  17
 None
 1.29A 1z95A-2psyA:
undetectable		 1z95A-2psyA:
23.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		6 / 6 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.26A 2otvA-2psyA:
38.8		 2otvA-2psyA:
47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 2psy KALLIKREIN-5
(Homo
sapiens) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.38A 2p16A-2psyA:
34.4		 2p16A-2psyA:
31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 2psy KALLIKREIN-5
(Homo
sapiens) 		6 / 8 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 216
GLY A 226
 None
 0.43A 2vinA-2psyA:
10.3		 2vinA-2psyA:
35.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		7 / 12 ASP A 189
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 None
 0.33A 2w26A-2psyA:
11.7		 2w26A-2psyA:
31.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 2psy KALLIKREIN-5
(Homo
sapiens) 		4 / 7 LEU A  40
ALA A  44
GLY A 197
PHE A 151
 None
 0.87A 2wq5A-2psyA:
undetectable		 2wq5A-2psyA:
17.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		9 / 11 HIS A  57
GLN A 174
ASP A 189
SER A 190
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
 0.69A 3gy3A-2psyA:
37.8		 3gy3A-2psyA:
47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 2psy KALLIKREIN-5
(Homo
sapiens) 		4 / 8 TRP A 215
ILE A 160
VAL A 138
GLY A 211
 None
 0.84A 3hjoB-2psyA:
undetectable		 3hjoB-2psyA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 12 LEU A  73
GLY A 193
GLY A 142
SER A 214
ALA A  32
 None
 1.12A 3i5uB-2psyA:
undetectable		 3i5uB-2psyA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2psy KALLIKREIN-5
(Homo
sapiens) 		4 / 5 ARG A 110
LEU A  52
ARG A  64
PHE A  63
 None
 1.22A 3ln1D-2psyA:
undetectable		 3ln1D-2psyA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		6 / 6 SER A 190
SER A 195
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.37A 3rxfA-2psyA:
15.2		 3rxfA-2psyA:
47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 5 ASP A 189
SER A 190
SER A 195
VAL A 213
GLY A 226
 None
 0.31A 3rxhA-2psyA:
38.7		 3rxhA-2psyA:
47.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 2psy KALLIKREIN-5
(Homo
sapiens) 		3 / 3 TYR A 228
ASP A 189
ASP A 185
 None
 0.88A 4a6eA-2psyA:
undetectable		 4a6eA-2psyA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 2psy KALLIKREIN-5
(Homo
sapiens) 		4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
 None
 0.82A 4fu8A-2psyA:
34.0		 4fu8A-2psyA:
35.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 9 VAL A 199
VAL A 200
VAL A 162
ILE A 160
SER A 139
 None
 1.15A 4fwdA-2psyA:
undetectable		 4fwdA-2psyA:
13.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HFP_D_15UD402_1
(PROTHROMBIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 12 HIS A  57
ASP A 189
VAL A 213
TRP A 215
GLY A 226
 None
 0.45A 4hfpD-2psyA:
14.9		 4hfpD-2psyA:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 12 LEU A 155
GLY A 140
GLN A  30
VAL A 199
ILE A  17
 None
 1.28A 4okbA-2psyA:
undetectable		 4okbA-2psyA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 12 LEU A 155
GLY A 140
GLN A  30
VAL A 199
ILE A  17
 None
 1.22A 4oktA-2psyA:
undetectable		 4oktA-2psyA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 12 LEU A 155
GLY A 140
GLN A  30
VAL A 199
ILE A  17
 None
 1.27A 4okwA-2psyA:
undetectable		 4okwA-2psyA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 2psy KALLIKREIN-5
(Homo
sapiens) 		5 / 12 HIS A  57
VAL A 213
TRP A 215
GLY A 216
GLY A 226
 None
 0.52A 4rn6B-2psyA:
28.5		 4rn6B-2psyA:
34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 2psy KALLIKREIN-5
(Homo
sapiens) 		3 / 3 LYS A 116
ASP A 117
ARG A 113
 None
ZN  A2001 (-2.8A)
None
 0.75A 5jwaA-2psyA:
undetectable
5jwaH-2psyA:
undetectable		 5jwaA-2psyA:
15.78
5jwaH-2psyA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 2psy KALLIKREIN-5
(Homo
sapiens) 		4 / 8 TRP A  51
GLY A  85
GLN A  84
SER A  88
 None
 1.11A 6eqpA-2psyA:
undetectable		 6eqpA-2psyA:
15.84