SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2pt5 SHIKIMATE KINASE
(Aquifex
aeolicus) 		5 / 10 PHE A  55
GLY A  78
GLY A  77
THR A  76
ILE A   6
 None
 1.49A 3fw1A-2pt5A:
2.9		 3fw1A-2pt5A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pt5 SHIKIMATE KINASE
(Aquifex
aeolicus) 		4 / 8 ARG A  22
SER A  14
LEU A 158
ILE A  99
 None
 0.91A 3ln1A-2pt5A:
undetectable		 3ln1A-2pt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pt5 SHIKIMATE KINASE
(Aquifex
aeolicus) 		4 / 7 ARG A  22
SER A  14
LEU A 158
ILE A  99
 None
 0.91A 3ln1B-2pt5A:
undetectable		 3ln1B-2pt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2pt5 SHIKIMATE KINASE
(Aquifex
aeolicus) 		4 / 7 ARG A  22
SER A  14
LEU A 158
ILE A  99
 None
 0.92A 3ln1C-2pt5A:
undetectable		 3ln1C-2pt5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 2pt5 SHIKIMATE KINASE
(Aquifex
aeolicus) 		4 / 7 ALA A 140
ASP A 141
VAL A 144
ILE A  74
 None
 0.60A 4eyrA-2pt5A:
undetectable		 4eyrA-2pt5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2pt5 SHIKIMATE KINASE
(Aquifex
aeolicus) 		5 / 11 ILE A   3
SER A  18
PRO A  27
LEU A  24
SER A  23
 None
 1.42A 6dlzA-2pt5A:
2.1
6dlzD-2pt5A:
2.1		 6dlzA-2pt5A:
19.14
6dlzD-2pt5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 2pt5 SHIKIMATE KINASE
(Aquifex
aeolicus) 		5 / 11 ILE A   3
SER A  18
PRO A  27
LEU A  24
SER A  23
 None
 1.42A 6dm1A-2pt5A:
2.0
6dm1D-2pt5A:
2.1		 6dm1A-2pt5A:
19.14
6dm1D-2pt5A:
19.14