SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pt6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 7 GLU A 154
SER A  69
THR A  67
VAL A  74
 None
 1.09A 1fo4B-2pt6A:
undetectable		 1fo4B-2pt6A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXV_B_PNNB1001_0
(PENICILLIN ACYLASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 7 MET A 243
SER A 197
PHE A 208
ALA A 228
 None
 1.23A 1fxvA-2pt6A:
undetectable
1fxvB-2pt6A:
undetectable		 1fxvA-2pt6A:
20.86
1fxvB-2pt6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
GLU A 147
ASP A 178
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-4.4A)
 0.86A 1jg2A-2pt6A:
7.9		 1jg2A-2pt6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLY A 126
GLU A 147
ASP A 178
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-4.4A)
 0.88A 1jg3A-2pt6A:
7.7		 1jg3A-2pt6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLY A 126
GLU A 147
ASP A 178
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-4.4A)
 0.89A 1jg3B-2pt6A:
3.1		 1jg3B-2pt6A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLY A 126
GLY A 128
GLY A 129
HIS A 103
ASP A 149
VAL A 152
 S4M  A 501 ( 4.4A)
None
None
S4M  A 501 (-3.7A)
None
S4M  A 501 ( 4.2A)
 1.44A 1n2xB-2pt6A:
13.4		 1n2xB-2pt6A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 ILE A 244
ALA A 247
VAL A 254
LEU A 310
ALA A 257
 None
 1.11A 1n4hA-2pt6A:
undetectable		 1n4hA-2pt6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
ILE A 148
ASP A 149
ASP A 178
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
 0.66A 1qaoA-2pt6A:
9.0		 1qaoA-2pt6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 125
GLY A 126
GLU A 147
ASP A 178
 S4M  A 501 (-3.4A)
S4M  A 501 (-4.2A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
 0.80A 1qzzA-2pt6A:
12.5		 1qzzA-2pt6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 8 ASP A 196
ILE A 145
ILE A 153
ILE A 163
 S4M  A 501 (-2.6A)
None
None
None
 0.64A 1sh9A-2pt6A:
undetectable		 1sh9A-2pt6A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_0
(SUN PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 128
GLY A 129
ILE A 148
ASP A 149
ASP A 178
 None
None
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
 0.40A 1sqfA-2pt6A:
9.9		 1sqfA-2pt6A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 125
GLY A 126
GLU A 147
ASP A 178
 S4M  A 501 (-3.4A)
S4M  A 501 (-4.2A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
 0.82A 1xdsA-2pt6A:
11.2		 1xdsA-2pt6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 125
GLY A 126
GLU A 147
ASP A 178
 S4M  A 501 (-3.4A)
S4M  A 501 (-4.2A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
 0.80A 1xdsB-2pt6A:
7.0		 1xdsB-2pt6A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 5 ALA A 101
TYR A 102
TYR A 264
GLN A  93
 None
S4M  A 501 (-4.9A)
None
S4M  A 501 (-4.1A)
 0.97A 1xl6A-2pt6A:
undetectable
1xl6B-2pt6A:
undetectable		 1xl6A-2pt6A:
18.31
1xl6B-2pt6A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		3 / 3 GLY A 124
GLU A 147
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-2.6A)
 0.63A 2b25B-2pt6A:
9.7		 2b25B-2pt6A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
GLU A 147
ILE A 148
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.5A)
 0.54A 2vdvE-2pt6A:
3.8		 2vdvE-2pt6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLY A 126
GLU A 147
ILE A 148
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.5A)
 0.54A 2vdvF-2pt6A:
3.8		 2vdvF-2pt6A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 5 ALA A 257
GLY A 280
LYS A 283
HIS A 304
 None
 1.37A 2yldA-2pt6A:
undetectable		 2yldA-2pt6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 5 ALA A 257
GLY A 280
LYS A 283
HIS A 304
 None
 1.34A 2ylgA-2pt6A:
undetectable		 2ylgA-2pt6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
ILE A 130
ASP A 149
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
None
S4M  A 501 (-3.5A)
 0.82A 2yqzA-2pt6A:
12.0		 2yqzA-2pt6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
ILE A 130
ASP A 149
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
None
S4M  A 501 (-3.5A)
 0.80A 2yqzB-2pt6A:
12.0		 2yqzB-2pt6A:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLN A 229
HIS A 103
ASP A 196
TYR A 264
PRO A 265
ILE A 261
 None
S4M  A 501 (-3.7A)
S4M  A 501 (-2.6A)
None
None
None
 1.45A 3b7pA-2pt6A:
51.0		 3b7pA-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		11 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
TYR A 264
PRO A 265
ILE A 269
 None
S4M  A 501 (-4.1A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
None
None
None
 0.26A 3b7pA-2pt6A:
51.0		 3b7pA-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_A_SPMA501_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
 1.43A 3b7pA-2pt6A:
51.0		 3b7pA-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		11 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLN A 229
TYR A 264
PRO A 265
ILE A 269
 None
S4M  A 501 (-4.1A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
None
None
None
 0.28A 3b7pB-2pt6A:
49.6		 3b7pB-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_B_SPMB502_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
 1.35A 3b7pB-2pt6A:
49.6		 3b7pB-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 HIS A 103
ASP A 196
TYR A 264
PRO A 265
ILE A 261
 S4M  A 501 (-3.7A)
S4M  A 501 (-2.6A)
None
None
None
 1.32A 3b7pC-2pt6A:
49.6		 3b7pC-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		12 / 12 TRP A  51
GLN A  93
TYR A 102
HIS A 103
ASP A 127
ASP A 196
ASP A 199
GLU A 231
SER A 232
TYR A 264
PRO A 265
ILE A 269
 None
S4M  A 501 (-4.1A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
None
None
None
None
 0.27A 3b7pC-2pt6A:
49.6		 3b7pC-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B7P_C_SPMC503_1
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 TYR A 102
HIS A 103
ASP A 127
ASP A 196
ILE A 259
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
 1.38A 3b7pC-2pt6A:
49.6		 3b7pC-2pt6A:
93.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		9 / 12 GLN A  72
TYR A 102
HIS A 103
GLY A 124
ILE A 148
ASP A 149
VAL A 152
ASP A 178
GLN A 229
 S4M  A 501 (-3.5A)
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-3.3A)
None
 0.66A 3bwcA-2pt6A:
38.8		 3bwcA-2pt6A:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		9 / 12 LEU A  88
TYR A 102
HIS A 103
GLY A 124
ASP A 127
ILE A 148
ASP A 149
VAL A 152
ASP A 196
 None
S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-3.4A)
S4M  A 501 (-2.9A)
S4M  A 501 (-3.9A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-2.6A)
 0.37A 3bwcB-2pt6A:
29.5		 3bwcB-2pt6A:
38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3BWC_B_SAMB501_0
(SPERMIDINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		7 / 12 TYR A 102
HIS A 103
GLY A 124
ASP A 127
ILE A 148
VAL A 152
GLN A 229
 S4M  A 501 (-4.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-3.4A)
S4M  A 501 (-2.9A)
S4M  A 501 (-3.9A)
S4M  A 501 ( 4.2A)
None
 0.71A 3bwcB-2pt6A:
29.5		 3bwcB-2pt6A:
38.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_A_SPMA501_1
(SPERMINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 TYR A 102
ASP A 127
ASP A 196
GLN A 229
TYR A 264
 S4M  A 501 (-4.9A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
 0.74A 3c6mA-2pt6A:
25.5		 3c6mA-2pt6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6M_D_SPMD501_1
(SPERMINE SYNTHASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 10 TYR A 102
ASP A 127
ASP A 196
GLN A 229
TYR A 264
 S4M  A 501 (-4.9A)
S4M  A 501 (-2.9A)
S4M  A 501 (-2.6A)
None
None
 0.75A 3c6mD-2pt6A:
25.4		 3c6mD-2pt6A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
ILE A 148
ASP A 149
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-4.4A)
 0.88A 3cjtO-2pt6A:
12.6		 3cjtO-2pt6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLY A 126
GLU A 147
ILE A 148
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.5A)
 0.44A 3ckkA-2pt6A:
4.4		 3ckkA-2pt6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLY A 126
GLU A 147
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.54A 3dxyA-2pt6A:
11.1		 3dxyA-2pt6A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		7 / 12 VAL A 123
GLY A 124
GLY A 126
GLU A 147
ASP A 149
ASP A 178
ALA A 179
 None
S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.57A 3fuuA-2pt6A:
11.5		 3fuuA-2pt6A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 11 GLY A 124
GLU A 147
ILE A 148
ASP A 149
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.37A 3grvA-2pt6A:
12.2		 3grvA-2pt6A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 11 GLY A 124
GLY A 126
ILE A 148
ASP A 149
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.90A 3grvA-2pt6A:
12.2		 3grvA-2pt6A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLY A 124
GLU A 147
ILE A 148
ASP A 149
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.43A 3gryA-2pt6A:
12.2		 3gryA-2pt6A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLY A 124
GLY A 126
ILE A 148
ASP A 149
ASP A 178
ALA A 179
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.97A 3gryA-2pt6A:
12.2		 3gryA-2pt6A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.73A 3id5B-2pt6A:
10.8		 3id5B-2pt6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.73A 3id5F-2pt6A:
10.7		 3id5F-2pt6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.70A 3id6C-2pt6A:
5.6		 3id6C-2pt6A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 8 PHE A  77
GLY A 128
SER A 164
ILE A 163
 None
 0.77A 3ihzB-2pt6A:
undetectable		 3ihzB-2pt6A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 128
GLY A 129
ASP A 149
ASP A 196
LEU A 207
 None
None
None
S4M  A 501 (-2.6A)
S4M  A 501 (-4.4A)
 0.70A 3m6vA-2pt6A:
10.1		 3m6vA-2pt6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_B_SAMB465_0
(RRNA METHYLASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 128
GLY A 129
ASP A 149
ASP A 196
LEU A 207
 None
None
None
S4M  A 501 (-2.6A)
S4M  A 501 (-4.4A)
 0.68A 3m6vB-2pt6A:
9.2		 3m6vB-2pt6A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 4 GLY A 124
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 0.75A 3mb5A-2pt6A:
12.8		 3mb5A-2pt6A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.70A 3nmuA-2pt6A:
undetectable
3nmuF-2pt6A:
10.1		 3nmuA-2pt6A:
22.14
3nmuF-2pt6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
GLU A 147
ASP A 178
ALA A 179
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-2.6A)
 0.76A 3nvkF-2pt6A:
undetectable
3nvkJ-2pt6A:
12.3		 3nvkF-2pt6A:
22.63
3nvkJ-2pt6A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 THR A 151
GLN A  72
ILE A 176
SER A  69
 None
S4M  A 501 (-3.5A)
None
None
 1.30A 3peoG-2pt6A:
undetectable		 3peoG-2pt6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 LEU A 134
PRO A 110
PRO A 117
TYR A 137
 None
 1.42A 3vkxA-2pt6A:
undetectable		 3vkxA-2pt6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 HIS A 103
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 (-3.7A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 1.27A 3vywA-2pt6A:
7.1		 3vywA-2pt6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 HIS A 103
GLY A 124
GLY A 126
ALA A 179
LEU A 207
 S4M  A 501 (-3.7A)
S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 1.22A 3vywB-2pt6A:
14.6		 3vywB-2pt6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 GLY A 126
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 ( 4.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 0.77A 3vywC-2pt6A:
13.4		 3vywC-2pt6A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 5 ALA A 257
GLY A 280
LYS A 283
HIS A 304
 None
 1.43A 3zwiA-2pt6A:
undetectable		 3zwiA-2pt6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		3 / 3 ASN A 142
ASP A 144
ASN A 173
 None
 0.62A 4agaA-2pt6A:
undetectable		 4agaA-2pt6A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 HIS A 103
GLU A 147
ASP A 178
ASP A 196
 S4M  A 501 (-3.7A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 1.37A 4blvA-2pt6A:
11.2		 4blvA-2pt6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		3 / 3 GLU A 147
ASP A 149
ASP A 178
 S4M  A 501 (-2.7A)
None
S4M  A 501 (-3.3A)
 0.33A 4gc9A-2pt6A:
9.8		 4gc9A-2pt6A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 TYR A 137
ASP A 127
HIS A 103
ASP A 196
GLY A 125
 None
S4M  A 501 (-2.9A)
S4M  A 501 (-3.7A)
S4M  A 501 (-2.6A)
S4M  A 501 (-4.2A)
 1.46A 4qa0B-2pt6A:
5.0		 4qa0B-2pt6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 7 GLY A 124
GLY A 126
ASP A 178
ASP A 196
 S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
S4M  A 501 (-3.3A)
S4M  A 501 (-2.6A)
 0.79A 5ergB-2pt6A:
9.5		 5ergB-2pt6A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 5 ALA A 257
GLY A 280
LYS A 283
HIS A 304
 None
 1.33A 5jliA-2pt6A:
undetectable		 5jliA-2pt6A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 5 ALA A 257
GLY A 280
LYS A 283
HIS A 304
 None
 1.33A 5jt4A-2pt6A:
undetectable		 5jt4A-2pt6A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		3 / 3 ILE A 143
VAL A 120
PRO A 117
 None
 0.66A 5uunA-2pt6A:
undetectable		 5uunA-2pt6A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 10 VAL A 123
GLY A 124
GLY A 126
ILE A 176
ALA A 179
 None
S4M  A 501 (-3.4A)
S4M  A 501 ( 4.4A)
None
S4M  A 501 (-3.5A)
 0.94A 5vm8B-2pt6A:
2.4		 5vm8B-2pt6A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA901_0
(MRNA CAPPING ENZYME
P5)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 11 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
 None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.93A 5x6yA-2pt6A:
4.5		 5x6yA-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 10 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
 None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.87A 5x6yB-2pt6A:
3.6		 5x6yB-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 11 GLU A 147
ASP A 178
ALA A 179
SER A 197
LEU A 207
 S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
None
S4M  A 501 (-4.4A)
 1.11A 5x6yC-2pt6A:
8.0		 5x6yC-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 11 VAL A 123
GLY A 124
GLU A 147
ASP A 178
ALA A 179
LEU A 207
 None
S4M  A 501 (-3.4A)
S4M  A 501 (-2.7A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.79A 5x6yC-2pt6A:
8.0		 5x6yC-2pt6A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		4 / 6 PRO A 265
GLY A 267
TYR A 264
LEU A 233
 None
 0.96A 5x80A-2pt6A:
undetectable
5x80B-2pt6A:
undetectable		 5x80A-2pt6A:
19.17
5x80B-2pt6A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		3 / 3 TYR A 264
HIS A 103
MET A 106
 None
S4M  A 501 (-3.7A)
None
 1.19A 6af6A-2pt6A:
undetectable		 6af6A-2pt6A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		7 / 12 GLN A  72
GLY A 124
ILE A 148
ASP A 149
VAL A 152
ASP A 178
ALA A 179
 S4M  A 501 (-3.5A)
S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.56A 6bq4A-2pt6A:
35.8		 6bq4A-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLN A  72
ILE A 148
ASP A 149
ALA A 179
LEU A 207
 S4M  A 501 (-3.5A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 1.00A 6bq4A-2pt6A:
35.8		 6bq4A-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_A_ADNA401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		6 / 12 GLY A 124
ILE A 148
ASP A 149
ASP A 178
ALA A 179
LEU A 207
 S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.4A)
 0.62A 6bq4A-2pt6A:
35.8		 6bq4A-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLN A  72
GLY A 124
ASP A 149
VAL A 152
ALA A 204
 S4M  A 501 (-3.5A)
S4M  A 501 (-3.4A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-3.6A)
 1.03A 6bq4B-2pt6A:
35.9		 6bq4B-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		7 / 12 GLN A  72
GLY A 124
ILE A 148
ASP A 149
VAL A 152
ASP A 178
ALA A 179
 S4M  A 501 (-3.5A)
S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
None
S4M  A 501 ( 4.2A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
 0.47A 6bq4B-2pt6A:
35.9		 6bq4B-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQ4_B_ADNB401_1
(THERMOSPERMINE
SYNTHASE ACAULIS
PROTEIN)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 124
ILE A 148
ASP A 178
ALA A 179
PRO A 203
 S4M  A 501 (-3.4A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.3A)
S4M  A 501 (-3.5A)
S4M  A 501 (-4.1A)
 0.54A 6bq4B-2pt6A:
35.9		 6bq4B-2pt6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_B_SAMB901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 2pt6 SPERMIDINE SYNTHASE
(Plasmodium
falciparum) 		5 / 12 GLY A 125
SER A  69
GLN A  72
ILE A 148
ASP A 178
 S4M  A 501 (-4.2A)
None
S4M  A 501 (-3.5A)
S4M  A 501 (-3.9A)
S4M  A 501 (-3.3A)
 1.21A 6bxnB-2pt6A:
3.6		 6bxnB-2pt6A:
23.81