SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2pt7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4TWD_F_377F401_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	2pt7	HYPOTHETICAL PROTEIN (Helicobacter pylori)	4 / 7	GLU G 118 GLU G 122 LEU G 174 TYR G 182	None	1.18A	4twdF-2pt7G: undetectable 4twdJ-2pt7G: undetectable	4twdF-2pt7G: 19.78 4twdJ-2pt7G: 19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5J7W_C_MTXC402_1 (THYMIDYLATE SYNTHASE)	2pt7	HYPOTHETICAL PROTEIN (Helicobacter pylori)	5 / 12	LEU G 188 LEU G 227 GLY G 225 ILE G 230 ALA G 231	None	1.21A	5j7wC-2pt7G: undetectable	5j7wC-2pt7G: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6QYA_B_FOZB401_0 (THYMIDYLATE SYNTHASE)	2pt7	HYPOTHETICAL PROTEIN (Helicobacter pylori)	5 / 12	LEU G 188 LEU G 227 GLY G 225 ILE G 230 ALA G 231	None	1.23A	6qyaB-2pt7G: undetectable	6qyaB-2pt7G: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6QYA_D_FOZD401_0 (THYMIDYLATE SYNTHASE)	2pt7	HYPOTHETICAL PROTEIN (Helicobacter pylori)	5 / 12	LEU G 188 LEU G 227 GLY G 225 ILE G 230 ALA G 231	None	1.23A	6qyaD-2pt7G: undetectable	6qyaD-2pt7G: 21.31

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4TWD_F_377F401_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","2pt7","HYPOTHETICAL PROTEIN","Helicobacter pylori",4,"GLU G 118;GLU G 122;LEU G 174;TYR G 182","None","1.18A","4twdF-2pt7G:undetectable;4twdJ-2pt7G:undetectable","4twdF-2pt7G:19.78;4twdJ-2pt7G:19.78"],["5J7W_C_MTXC402_1","THYMIDYLATE SYNTHASE","2pt7","HYPOTHETICAL PROTEIN","Helicobacter pylori",5,"LEU G 188;LEU G 227;GLY G 225;ILE G 230;ALA G 231","None","1.21A","5j7wC-2pt7G:undetectable","5j7wC-2pt7G:21.31"],["6QYA_B_FOZB401_0","THYMIDYLATE SYNTHASE","2pt7","HYPOTHETICAL PROTEIN","Helicobacter pylori",5,"LEU G 188;LEU G 227;GLY G 225;ILE G 230;ALA G 231","None","1.23A","6qyaB-2pt7G:undetectable","6qyaB-2pt7G:21.31"],["6QYA_D_FOZD401_0","THYMIDYLATE SYNTHASE","2pt7","HYPOTHETICAL PROTEIN","Helicobacter pylori",5,"LEU G 188;LEU G 227;GLY G 225;ILE G 230;ALA G 231","None","1.23A","6qyaD-2pt7G:undetectable","6qyaD-2pt7G:21.31"]]