SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ptf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W1W_A_CHDA1507_0 (FERROCHELATASE, MITOCHONDRIAL)	2ptf	UNCHARACTERIZED PROTEIN MTH_863 (Methanothermobac ter thermautotrophic us)	3 / 3	ARG A 135 LYS A 140 ARG A 137	None	1.47A	3w1wA-2ptfA: 0.0 3w1wB-2ptfA: 0.0	3w1wA-2ptfA: 21.51 3w1wB-2ptfA: 21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVY_K_BO2K301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	2ptf	UNCHARACTERIZED PROTEIN MTH_863 (Methanothermobac ter thermautotrophic us)	5 / 10	ALA A 150 ALA A 148 ALA A 124 VAL A 153 GLY A 58	None	0.92A	4qvyK-2ptfA: undetectable 4qvyL-2ptfA: undetectable	4qvyK-2ptfA: 20.62 4qvyL-2ptfA: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QVY_Y_BO2Y301_1 (PROTEASOME SUBUNIT BETA TYPE-5 PROTEASOME SUBUNIT BETA TYPE-6)	2ptf	UNCHARACTERIZED PROTEIN MTH_863 (Methanothermobac ter thermautotrophic us)	5 / 10	ALA A 150 ALA A 148 ALA A 124 VAL A 153 GLY A 58	None	0.91A	4qvyY-2ptfA: undetectable 4qvyZ-2ptfA: undetectable	4qvyY-2ptfA: 20.62 4qvyZ-2ptfA: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GTQ_A_ACTA204_0 (N-ACETYLTRANSFERASE)	2ptf	UNCHARACTERIZED PROTEIN MTH_863 (Methanothermobac ter thermautotrophic us)	4 / 5	LEU A 55 THR A 63 CYH A 56 THR A 61	None	1.21A	6gtqA-2ptfA: undetectable	6gtqA-2ptfA: 20.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3W1W_A_CHDA1507_0","FERROCHELATASE, MITOCHONDRIAL","2ptf","UNCHARACTERIZED PROTEIN MTH_863","Methanothermobacter thermautotrophicus",3,"ARG A 135;LYS A 140;ARG A 137","None","1.47A","3w1wA-2ptfA:0.0;3w1wB-2ptfA:0.0","3w1wA-2ptfA:21.51;3w1wB-2ptfA:21.51"],["4QVY_K_BO2K301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","2ptf","UNCHARACTERIZED PROTEIN MTH_863","Methanothermobacter thermautotrophicus",5,"ALA A 150;ALA A 148;ALA A 124;VAL A 153;GLY A  58","None","0.92A","4qvyK-2ptfA:undetectable;4qvyL-2ptfA:undetectable","4qvyK-2ptfA:20.62;4qvyL-2ptfA:22.39"],["4QVY_Y_BO2Y301_1","PROTEASOME SUBUNIT BETA TYPE-5;PROTEASOME SUBUNIT BETA TYPE-6","2ptf","UNCHARACTERIZED PROTEIN MTH_863","Methanothermobacter thermautotrophicus",5,"ALA A 150;ALA A 148;ALA A 124;VAL A 153;GLY A  58","None","0.91A","4qvyY-2ptfA:undetectable;4qvyZ-2ptfA:undetectable","4qvyY-2ptfA:20.62;4qvyZ-2ptfA:22.39"],["6GTQ_A_ACTA204_0","N-ACETYLTRANSFERASE","2ptf","UNCHARACTERIZED PROTEIN MTH_863","Methanothermobacter thermautotrophicus",4,"LEU A  55;THR A  63;CYH A  56;THR A  61","None","1.21A","6gtqA-2ptfA:undetectable","6gtqA-2ptfA:20.68"]]