SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2ptg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		5 / 11 TYR A 283
VAL A 370
GLY A 371
VAL A 105
VAL A 229
 None
 1.12A 1akdA-2ptgA:
undetectable		 1akdA-2ptgA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		6 / 12 ALA A 106
PHE A 261
LEU A 264
ALA A 185
VAL A 321
LEU A 378
 None
 1.32A 1fm9A-2ptgA:
undetectable		 1fm9A-2ptgA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_1
(HYPOTHETICAL PROTEIN)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		4 / 4 GLY A 208
GLU A 213
ASP A 184
TYR A 203
 None
 1.41A 2yvlC-2ptgA:
6.8		 2yvlC-2ptgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_A_1FLA502_1
(TRANSTHYRETIN)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		4 / 7 LEU A 232
ALA A 280
SER A 327
VAL A 323
 None
 0.88A 3d2tA-2ptgA:
undetectable		 3d2tA-2ptgA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		6 / 12 ALA A 106
PHE A 261
LEU A 264
ALA A 185
VAL A 321
LEU A 378
 None
 1.34A 3oapA-2ptgA:
undetectable		 3oapA-2ptgA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		5 / 10 ILE A 211
ASP A 188
ALA A 185
ILE A 118
ILE A 284
 None
 1.20A 3prsA-2ptgA:
undetectable		 3prsA-2ptgA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		5 / 12 PHE A 261
TYR A 114
ALA A 373
GLY A 371
LEU A 375
 None
 1.49A 4oadA-2ptgA:
undetectable		 4oadA-2ptgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		5 / 12 GLY A 115
SER A 111
HIS A 230
VAL A 105
VAL A 129
 None
 1.10A 5dpdA-2ptgA:
5.5		 5dpdA-2ptgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		4 / 6 PHE A 177
THR A 133
ASP A 110
GLY A 113
 None
 1.13A 5mraA-2ptgA:
undetectable
5mraB-2ptgA:
undetectable		 5mraA-2ptgA:
21.52
5mraB-2ptgA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		4 / 7 GLY A 115
GLY A 113
SER A 327
ALA A 374
 None
 0.78A 5o96C-2ptgA:
2.6		 5o96C-2ptgA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2ptg ENOYL-ACYL CARRIER
REDUCTASE
(Eimeria
tenella) 		5 / 11 GLY A 115
GLY A 113
SER A 327
ARG A 372
ALA A 374
 None
 1.01A 5o96G-2ptgA:
2.3		 5o96G-2ptgA:
21.25